Research May Lead to Treatment of Type I Diabetes

DALLAS, Physicians on staff at Baylor University
Medical Center at Dallas performed their first islet cell transplant to treat
a patient with Type I diabetes.

luzerne infected

With the promise of ubiquitous true broadband
service, we can imagine a day when the life functions of many people with
disabilities are truly revolutionized.org

About ACB
The Council strives to improve the well-being of all blind and visually
impaired people by: serving as a representative national organization of blind
people; elevating the social , economic and cultural levels of blind people;
improving educational and rehabilitation facilities and opportunities;
cooperating with the public and private institutions and organizations
concerned with blind services; encouraging and assisting all blind persons to
develop their abilities and conducting a public education program to promote
greater understanding of blindness and the capabilities of blind people. Since its inception,
physicians have performed more than 7,000 solid organ transplants , including
liver, kidney, pancreas, heart and lung, as well as blood and marrow
transplants. Lanphier . We are on track to initiate the Phase 2 study
of SB-509 in the second half of 2006. Sangamo is also developing sequence-specific ZFP
Nucleases (ZFN(TM)) for therapeutic gene modification as a treatment for a
variety of monogenic diseases, such as sickle cell anemia, and for infectious
diseases, such as HIV. For more information about Sangamo,
visit the company's web site at http://www.

This press release may contain forward-looking statements based on
Sangamo's current expectations .

blindness mayville

Baylor's transplant program was established in 1983. SAN FRANCISCO, Sangamo BioSciences , Inc. We expect to present data
from the Phase 1 study at the American Academy of Neurology Meeting in San
Diego in April 2006 and the American Diabetes Association Scientific Sessions
in Washington , DC in June 2006. Clinical evaluations will include neurological examination and
electrophysiological testing. See the company's SEC filings, and in
particular, the risk factors described in the company 's Annual Report on Form
10-K and its most recent 10-Q.

pku oregonia

Since the functionality is the same, so too should be the regulations
governing the service. On March 12, the islet cells were
flown from Miami to Baylor University Medical Center at Dallas. She has not
experienced any side effects from this medication," added Levy. The total annual economic cost of
diabetes in 2002 was estimated to be $132 billion, or one out of every 10
health care dollars spent in the United States. Edward Lanphier , Sangamo's president and CEO, will
present details of the study at the Conference at 1:30 p. This is gradually replaced by loss of
sensation and motor function as nerve damage progresses.

catcher superkids

acb.org

From 10 to 21 percent of all people with diabetes have kidney disease
(diabetic nephropathy ). For more information
about the Baylor Regional Transplant Institute, which comprises transplant
programs at Baylor University Medical Center at Dallas and Baylor All Saints
Medical Center at Fort Worth, visit http://www. The American Diabetes
Association estimates that there are approximately 18.com.

colitis weeklong

It is a necessity of basic communication
for people with disabilities. The NAD also offers grassroots and
youth leadership development, and legal expertise across a broad spectrum of
areas including but not limited to accessibility, education, employment,
healthcare, mental health, rehabilitation , technology, telecommunications, and
transportation.
http://www. and ended at 9:50 p.
"Jennifer has started producing her own insulin for the first time in
20 years," said Marlon Levy , M.
Approximately 43 percent of new cases of end-stage renal disease are
attributed to diabetes .

kindle barnabas

S.
Shannon went from the procedure directly to a patient floor, where she had
blood taken every few hours.
Eventually, the damaged filters are destroyed, putting more stress on the
remaining filters and eventually causing them to become damaged. To survive with end-stage renal disease, patients
require dialysis or a kidney transplant."
Sangamo is proposing to undertake a placebo-controlled , multi-treatment
Phase 2 study in diabetic subjects with mild to moderate sensory/motor
neuropathy . By
engineering ZFPs that recognize a specific DNA sequence Sangamo has created
ZFP transcription factors (ZFP TF(TM)) that can control gene expression and,
consequently, cell function. Sangamo BioSciences , Inc.

dialysis kindle

aapd-dc. WID's work focuses on four
areas: employment and economic development; accessible health care and
Personal Assistance Services; inclusive technology design; and international
disability and development. Over half of the Board of Directors and staff are
people with disabilities and are respected national leaders in the disability
field as well as in industry, government and social services. Each year, nearly 130,000 people
receive kidney transplants as a result of the diabetes.m.

seizures kindle

Fifteen Years After Passage of the Americans with Disabilities Act
Necessities of Basic Communication Are Still Out of Reach for Many Americans

WASHINGTON, Four prominent disability rights
organizations strongly urged Congress to make update of the 1996
Telecommunications Act their highest priority to foster the more rapid
deployment of broadband technology to all Americans and to include provisions
that ensure access to communications for persons with disabilities.D.
After the pancreas was surgically recovered from the deceased donor, it
was taken to the University of Miami School of Medicine. There, scientists
separated the islet cells from the donor pancreas , then cultured the islet
cells to ensure the viability of the cells.com . today, Thursday,
January 12, 2006 (PST).

About Diabetic Neuropathy
Diabetic peripheral sensory motor neuropathy is one of the most frequent
complications of diabetes. Ulcers and sores may
appear on numb areas of the foot because pressure or injury goes unnoticed.

impaired esperanza

m.
Nationwide, more than one million people have Type 1 (juvenile onset)
diabetes. In diabetic nephropathy, blood vessels in the kidneys
that filter wastes, chemicals and excess water from the blood become damaged. When the
entire filtration system breaks down, the kidneys fail to function, resulting
in end-stage renal disease.

Sangamo BioSciences Announces Plans for Phase 2 Clinical Trial of ZFP Therapeutic in Diabetic Neuropathy at JPMorgan Healthcare Conference

(Nasdaq: SGMO) today announced that it will outline plans for a Phase 2
clinical trial of SB-509 in subjects with mild to moderate diabetic neuropathy
at its presentation at the 24th annual JPMorgan Healthcare Conference.

About SB-509
SB-509 is administered as an injectable formulation of plasmid DNA that
encodes a zinc finger DNA-binding protein transcription factor (ZFP TF(TM)),
designed to upregulate the VEGF-A gene.

barnabas oregonia

Said NAD
chief executive officer Nancy J.
NAD, AAPD, ACB and WID urge Congress to develop and pass comprehensive
telecommunications legislation that will include provisions that ensure access
for people with disabilities.

Baylor University Medical Center at Dallas Patient See Positive Results From First Islet Cell Transplant

, medical director of the islet cell
transplant program, Baylor University Medical Center at Dallas.
The islet cell transplant was performed in Baylor's interventional
radiology procedure room.BaylorHealth . assumes no obligation
to update the forward-looking information contained in this press release .

kindle purdy

"
Citing a report issued last month, Two-Way Technologies: A History of the
Struggle to Communicate , by Hofstra University Professor Frank Bowe, the
groups underscore the fact that the quality of life for many people with
disabilities rests on decisions that only Congress can make. Bowe's report is available online at
http://people. Shannon has come to Baylor Dallas everyday
throughout this week to have her blood drawn, allowing physicians to monitor
her blood sugar and immunosuppressant levels. Safety will be monitored throughout the
study. The study will be conducted at multiple centers
and subject enrollment is expected to take approximately twelve months. More than 60% of non-traumatic lower-limb amputations in the United
States occur among people with diabetes. According to the CDC , diabetes is becoming more
common in the United States.

kindle seizures

Make Telecom Update Your Highest Priority Disability Groups Tell Congress

Congress had a bold vision when it enacted the Americans with
Disabilities Act fifteen years ago.html

About AAPD
American Association of People with Disabilities is the largest national
nonprofit cross-disability member organization in the United States, dedicated
to ensuring economic self-sufficiency and political empowerment for the more
than 56 million Americans with disabilities.org

About WID
The World Institute on Disability (WID) is a nonprofit research, public
policy and advocacy center dedicated to promoting the civil rights and full
societal inclusion of people with disabilities.
http://www. Jennifer Shannon, a 26-year-old, 4th grade
teacher from Saginaw, Texas, received her transplant on Saturday, March 12."
Dr. Interventional radiologists on staff at Baylor
Dallas used ultrasound technology to inject the islet cells into Shannon's
portal vein, which branches out to the liver.

bellefontaine impaired

Bloch: "Thousands of deaf and hard of
hearing Americans are now 'making phone calls' using high-speed broadband
connections.
"The U. To fully realize that vision, we need
telecom policy reform that ensures the incorporation of accessibility features
in new technologies from the design phase," said Melanie Brunson, executive
director of the American Council of the Blind. Subjects will be assigned to one of three treatment groups which
will be administered a placebo, SB-509 every 2 months for three treatments or
SB-509 every 3 months for three treatments. VEGF-A has been demonstrated to have
direct neurotrophic and neuroprotective properties. From 1980 through 2002, the number of Americans
with diabetes more than doubled. Actual results may differ materially from
these forward-looking statements due to a number of factors, including
uncertainties relating to the initiation and completion of stages of the SB-
509 clinical trial , whether the SB-509 clinical trial will validate and
support tolerability and efficacy of SB-509 , technological challenges,
Sangamo's ability to develop commercially viable products and technological
developments by our competitors.

superkids dialysis

Mr. According to the United Network of Organ Sharing, Baylor 's
transplant survival rates exceed the national standard. Subjects receiving SB-509 will be
treated with the maximum tolerated dose of the ZFP Therapeutic by
intramuscular injection in both legs.

colitis bellefontaine

As we develop applications like Voice-over-Internet-Protocol
(VoIP) telephony, wireless broadband Internet connectivity and other advances,
it is critical that these technologies increase the inclusion , independence
and empowerment of Americans with disabilities, as well as America's growing
senior population," stated Andrew Imparato, President and CEO of the American
Association of People with Disabilities.hofstra. AAPD works in coalition with
other disability organizations for the full implementation and enforcement of
disability nondiscrimination laws, particularly the Americans with
Disabilities Act (ADA) of 1990 and the Rehabilitation Act of 1973.
http://www. The
procedure started at 8:40 p.3 million people with
diabetes in the United States and that of those about 60% to 70% have mild to
severe forms of neuropathy.

seizures oregonia

One of the
report's recommendations is that people with disabilities be assured
accessibility to services delivered over broadband connections, just as they
now are to the same services offered over traditional phone lines. The islet cell infusion
took 12 minutes , starting at 9:19 p. "She still
requires low doses of insulin each day, but her blood sugar control has
improved. At that time,
Baylor's islet cell specialists performed final testing and prepared the cells
for infusion into Shannon.
People with Type 1 diabetes are at increased risk for many serious
complications, including heart disease, blindness, nerve damage and kidney
damage .
In addition to potentially severe medical complications, diabetes has
significant economic ramifications.
"The progression of our first ZFP Therapeutic program into Phase 2
clinical trials is a significant clinical development milestone for Sangamo,"
said Mr.

About Sangamo
Sangamo BioSciences, Inc.

pku weeklong

m. Shannon was
discharged from Baylor Dallas the next day. Levy says the goal of the islet cell research at Baylor Dallas is to
achieve normal blood sugar-levels in patients with diabetes, which would
ultimately prevent the disease's major complications, such as blindness, heart
disease and kidney damage.

illnesses mayville

org

About NAD
The NAD, as a national federation of state association and organizational
affiliates, safeguards the civil rights of 28 million deaf and hard of hearing
people in the United States of America.

colitis kerrville

In a letter sent to members of the House and Senate Commerce committees in
conjunction with the 15th Anniversary of the enactment of the Americans with
Disabilities Act (ADA), the National Association of the Deaf (NAD), the
American Association for Persons with Disabilities (AAPD), the American
Council of the Blind (ACB) and the World Institute on Disability (WID) state,
"Broadband is not just nice to have.m.
Baylor received approval from the Food and Drug Administration to begin a
research study of islet cell transplantation in July 2004. is focused on the research and development of
novel DNA-binding proteins for therapeutic gene regulation and modification. Sangamo's core competencies enable the engineering of a class of
DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs).

bellefontaine kindle

m. We expect Jennifer to have another infusion of islet cells in the
next few weeks. Symptoms include numbness, tingling sensations and
pain particularly in the toes or feet. In the period from 2000 to 2001 this
translated to approximately 82,000 amputations. Other therapeutic development
programs are focused on macular degeneration, ischemic heart disease,
congestive heart failure, neuropathic pain, and infectious and monogenic
diseases.

colitis oregonia

Shannon received nearly 300,000 islet cells during her infusion. SB-509
is a novel ZFP Therapeutic(TM) designed to upregulate the expression of the
patient's own vascular endothelial growth factor (VEGF) gene to protect and
stimulate the regeneration of peripheral nerve function in diabetics suffering
from peripheral neuropathy. Sangamo has established several Enabling Technology
Agreements with companies to apply its ZFP Technology to enhance the
production of protein pharmaceuticals.

chaperones dialysis

Fifteen patients,
both men and women, between the ages of 18 and 65 will be enrolled in the
study. "We announced completion of enrollment of subjects in the
Phase 1 study of SB-509 in November 2005 and did not observe any drug-related
severe adverse events or dose-limiting toxicity. In preclinical animal
efficacy studies in a diabetic rat model , SB-509 has proven effective in
protecting motor and sensory nerve function from disease-induced nerve damage.sangamo.

This category is for traditional summer camps and programs for kids and/or teens with special needs, such as ADHD, physical disabilities, diabetes, or blindness.

colitis superkids

We can sign to each other, just as other people speak to each
other."
"New technologies are increasing the independence and productivity of many
Americans.edu/faculty/frank_g_bowe/Two-Way_Technologies. ending at 9:31 p.
"To keep her body from rejecting the islet cells, Jennifer will take
immunosuppressant medication daily for the rest of her life. Diabetes -- the fifth deadliest disease in the United States --
affects the body's ability to produce or respond to insulin, a hormone that
allows blood glucose (blood sugar) to enter the cells of the body and be used
for energy.
The most advanced ZFP Therapeutic (TM) development programs are currently in
Phase I clinical trials for evaluation of safety in patients with diabetic
neuropathy and peripheral artery disease.

eustis chaperones

wid. Specific services include public information and
dissemination; information and referral services; technical assistance,
training seminars; national and regional conferences; legal and public policy
analysis, guidance and research; and litigation consultation services.
http://www.nad.
Despite adequate treatment, these areas of trauma frequently become infected
and this infection may spread to the bone, necessitating amputation of the leg
or foot. These forward-looking statements include,
without limitation, references to the clinical trials of SB-509, research and
development of novel ZFP TFs and ZFNs and therapeutic applications of
Sangamo 's ZFP technology platform.