Median time to progression was 25. Factors that may affect
the Group's operations are described under 'Risk Factors ' in the Operating and
Financial Review and Prospects in the company's Annual Report on Form 20-F for
2004. FORNEBU, Norway, Statistics compiled by
Telenor show that the amount of both spam and virus increased substantially in
2004. During the last
six months of the year the virus activity was somewhat lower.P
2.D
345.AT
119.

slovensky kazn

Results for one-year survival rate, the study's primary endpoint, were
similar between groups (25.1 weeks for PE versus 24.9 percent for patients in the PE group.162. This service has substantially
increased the security in the early outbreak-phase of a new virus.
from Telenor) will remove the problem before the e-mail reaches the
recipient's network/server/PC
* Install personal anti-virus software and a firewall on the home PC
* Run upgrades of the operative system with respect to detecting security
defects
* Be critical with respect to the files you download, mails you open etc.no/bedrift /sikkerhet.

ctvo hospod

19 [95% CI 1.
"Results from this study clearly show that oral Hycamtin has activity in
NSCLC and may provide another treatment option for relapsed patients with the
convenience of oral therapy," said Roman Perez-Solar, M.02). Interaction between topo-I and Hycamtin results in damage to
the cell's genetic material and the death of dividing cancer cells. Telenor's spam and virus filters killed a total of
652 million spam messages and 23 million viruses in 2004.
In January, in an effort to help customers repel unwanted attacks, Telenor
installed a central virus filter on all outgoing e-mails.
"Now that we have installed a central virus filter on our servers, we are
able to stop nearly all the viruses that customers send.186 WORM_NETSKY.H
285.

elektronika hospod

"Oral Hycamtin may be a convenient therapy for patients who might
otherwise choose best supportive care over intravenous chemotherapy -- either
because they reside a long distance from the hospital or because they prefer
to live their remaining few weeks of life at home," said study investigator,
John Eckardt, M.

About Hycamtin
Hycamtin is a chemotherapeutic agent that belongs to a class of drugs
known as topoisomerase I (topo-I) inhibitors.gsk.552 WORM_NETSKY.Q
371.C
160.Z
126.305 WORM_BUGBEAR.telenor.

rekon lesn

Both studies were presented here this week at the annual
meeting of the American Society of Clinical Oncology (ASCO) (Abstracts 7003
and 7017).3 weeks for patients given oral
Hycamtin.3 weeks in the TC group and 40. Time to progression for patients in the PE group was significantly
longer compared to the TC group (Hazards Ratio 1. Hycamtin IV is also
indicated for the treatment of metastatic ovarian cancer after failure of
initial or subsequent chemotherapy.
For more information and full prescribing information , please visit
http://www.
Telenor currently has approximately 950. Already two weeks
after the filter was in operation, Telenor registered that the number of
viruses sent from our customers has been reduced substantially.232 WORM_NETSKY.455 WORM_ZAFI. Here are a few useful steps:

* Install net centric virus and spam filters.

biotechnol medzin

With regard to differences in one-year survival between
groups, Hycamtin was shown to be non-inferior to docetaxel based on the
study's pre-specified non-inferiority margin. Median TTP was 13.
"While Hycamtin is well established in the treatment of relapsed sensitive
disease small cell lung cancer, results from this study show that Hycamtin ,
combined with platinum, may produce results similar to the gold standard of
care while offering greater convenience with oral administration," said Dr.
Eckardt.
The randomized phase III study included a total of 784 chemotherapy-naove
patients with extensive disease.
Hycamtin , in its intravenous (IV) form, is currently indicated for use in
treating SCLC sensitive disease after failure of first-line chemotherapy.b was causing much
trouble.396 PE_ZAFI.748 WORM_NETSKY .

ctvo medzin

Study Shows Oral Hycamtin Clinically Active in SCLC
Results from a separate study of oral Hycamtin, one of the largest ever
conducted in patients with extensive (disease that has spread beyond the
chest) SCLC, showed that oral Hycamtin administered with IV cisplatin (TC) was
similar with regard to activity and tolerability to IV etoposide/cisplatin
(PE), the standard of care for first-line extensive disease SCLC.1 weeks for
TC.

Important Safety Information
Hycamtin(R) (topotecan HCl for Injection) can suppress the body's ability
to produce disease fighting white blood cells, a condition known as
neutropenia. Online ADSL customers
also have access to Norton Anti-virus software, which can be downloaded and
installed on customers' PCs.
The major viruses (ranked according to the extent of their distribution)
in 2004 were:

Number Virus name
7.989 WORM_MIMAIL. Johannessen, Telenor Division Business
Market: +47 481 91 921
Head of information Atle Lessum, Telenor Division Consumer Market:
+47 415 05 645

trukcie rekon

"Results from these two
investigational studies suggest that oral Hycamtin may one day be an important
alternative for these patients.0196).
Overall survival , the study's primary endpoint, was similar between
groups, with a median survival time of 39.19 [95 % CI 1. For more information, visit http://www.M
77.F
57.AH
45.

elektronika obchodn

D .3
weeks in the PE group.hycamtin. The most common serious adverse
event is myelosuppression.

About GlaxoSmithKline
GlaxoSmithKline (NYSE: GSK) is one of the world's leading research -based
pharmaceutical and healthcare companies. The trend that emerged in 2003,
that spam is distributed trough virus-infected home PCs, continued with
renewed strength in 2004. In comparison,
Telenor removed 90 million spam messages and 2.
Most of the spam mails are attempts at selling different kinds of
products, but we also see that many are direct attempts at fraud. A net centric filter (e.

tovn obchod

1 percent for oral Hycamtin versus 28. A total of 25 complete responses
and 220 partial responses were observed in the TC group versus 21 complete
responses and 251 partial responses in the PE group .

Telenor Reduces Internet Virus Risk

W
179.819 WORM_MYDOOM.

ctvo rekon

Nineteen patients in each group (4. As the
largest player in the market, Telenor also offers a number of security
services - ranging from around the clock monitoring of attempts at data
hacking, to dynamic filters that kill spam and virus.I
326.

rstvo stavba

One percent of patients given oral
Hycamtin experienced sepsis compared to five percent for docetaxel. Topo-I is an enzyme essential
for the replication of DNA , and therefore cell division, in both normal and
cancer cells.701 WORM_SOBER.741 WORM_SWEN .551 WORM_BAGLE.

obchod biotechnol

ORLANDO, Fla. A total of 829 previously-treated
patients were recruited from 140 centers worldwide.9 weeks versus 30.38]; P =
0.com. In spite of all the virus attacks,
Telenor 's distribution of e-mail was never brought to a halt. "Phishing"
is an example in the latter category , where criminals attempt to steal
identities from serious companies with the aim of acquiring personal
information, such as account numbers, PIN codes and similar from private
individuals.408.532 WORM_LOVGATE.GEN-1
74.

trukcie nohospod

Oral Hycamtin was also similar
to docetaxel in median survival (27. In
clinical studies, sensitive disease was defined as disease responding to
chemotherapy but subsequently progressing at least 60 days (in the Phase III
study) or at least 90 days (in the Phase II study). Hycamtin is contraindicated in patients who have a
history of hypersensitivity reactions to topotecan or any of its ingredients.

Statistics from Telenor reveal that the amount of infected e-mails
increased dramatically in 2004. We are also likely to see more attempts at
hacking, where sensitive information stored on PCs can be misused.451.077.B
1.740 WORM_KLEZ.

medzin obchod

Results from one trial showed Hycamtin to be one of the first oral
chemotherapeutic agents to demonstrate clinical activity in a phase III study
of patients with relapsed stage III /IV NSCLC.

obchodn jedlo

, Results from two new,
investigational Phase III clinical trials showed that oral Hycamtin (R) was
clinically active in both small cell lung cancer (SCLC) and non-small cell
lung cancer (NSCLC)."

Study Shows Oral Hycamtin Clinically Active in Relapsed NSCLC
One open-label , phase III trial studied the risk/benefit profile of oral
Hycamtin compared with IV docetaxel. One -year survival rate was 31. At the least
suspicion of a virus, e-mails will be quarantined for further analysis,
pending further efficient virus signature.

elektronika ivnostn

New Investigational Studies Showed Oral Hycamtin (R) (Topotecan Hydrochloride) Clinically Active in the Treatment of Small Cell and Non-Small Cell Lung Cancer

1
weeks for patients given docetaxel versus 11. Patients were randomized to receive either
1.7 mg/m2/day due to excessive neutropenia, diarrhea, and
typhilitis (a complication of neutropenia leading to ulceration of the colon).
Hycamtin should not be used in patients who are pregnant or breast-feeding, or
in those with severe one marrow depression. GlaxoSmithKline is committed to
improving the quality of human life by enabling cancer patients to do more,
feel better and live longer.com . This applies for both e-mail viruses and
network viruses. This reduces the
spread of the viruses substantially, and trough our monitoring we have
registered that the amount of viruses is down by around a third," says Rolv-
Erik Spilling.A
623.R
209.

hospod obchod

Additionally, results from one
of the largest studies conducted in extensive SCLC disease showed that oral
Hycamtin , combined with cisplatin, demonstrated clinical activity and
tolerability similar to IV etoposide /cisplatin, the standard of care. Patients given IV docetaxel in the study experienced significantly
longer time to progression (TTP) compared to those given oral Hycamtin
(Hazards Ratio 1.
A safety analysis of the treated population was conducted in 407 patients
receiving oral Hycamtin and 401 patients receiving IV docetaxel.03, 1. The initial TC dose regimen, containing Hycamtin 2.
The virus activity at Telenor was highest in the first half of 2004, and
reached its peak in June , when the e-mail virus zafi. We
recommend that all users take precautionary measures and protect themselves
with the help of filters and we also recommend that they download security
updates from software suppliers," says Rolv-Erik Spilling, director of
Internet and data communications at Telenor Business Market.
Individual Internet users can also protect themselves against spam and
viruses by simple means.

umenie robky

At this time, oral Hycamtin does not have regulatory approval in
any country for use in any indication. Patients were randomized
to receive either single agent oral Hycamtin 2.37]; P = 0. In both
groups, less than 1 percent of patients died from hematologic or
nonhematologic toxicity-related causes. Overall response rate was 63 percent for patients in the TC group versus
68. In addition to the Zafi virus, different versions of the Netsky and
the Mydoom viruses also made a huge impact. Viruses may
lie hidden in e-mails, or they may take control of people 's computers without
the owners being aware of it.Z
459.950 WORM_BAGLE.G

In addition to the central virus filter for outgoing e-mails, Telenor also
introduced "virus radar " in 2004, as part of Telenor's central Virus Scan
service.

rstvo reklama

Louis, Missouri.7 weeks, respectively ). There are now more than 100,000 known viruses in the world.
"This year we expect an increase of so-called smart viruses.B
3.A
128.929 WORM_BAGLE.

jedlo nohospod

Oral
Hycamtin was associated with more grade 3 thrombocytopenia, grade 3/4 anemia
and overall GI symptoms while patients given IV docetaxel experienced more
grade 3/4 neutropenia and neuropathy.0 mg/m2/day,
was reduced to 1.
The amount of Spam, or trash-mail, also increased in 2004.1 million viruses in 2003, and
if we look at the number of customers who have installed virus and spam
filters this counted for between 40 and 50 per cent.634 WORM_NETSKY.D
3.319 PE_DUMARU.283 WORM_BAGLE .745 WORM_SOBER.

obchodn biotechnol

3 mg/m2 daily on days 1-5,
every 21 days (n=414) or IV docetaxel 75 mg/m2 on day 1, every 21 days
(n=415).7 percent for
IV docetaxel).6 percent) achieved a complete or partial
response, and stable disease was observed in 111 patients (26.7 mg/m2 oral Hycamtin on days 1-5 and 60 mg/m2 cisplatin on day 5 (TC, n =
389) or IV etoposide 100 mg/m2 on days 1-3 and 80 mg/m2 cisplatin on day 1
(PE, n = 395). In addition, the amount of clotting cells can decrease
(thrombocytopenia ).979.

lesn tovn

, director of the clinical research program at the Center
for Cancer Care and Research, St.

8 percent) in
the oral Hycamtin group versus 148 patients (35.7 percent) in the IV docetaxel
group .
The median number of cycles for TC was five (range: 1-9) and six for PE
(range: 1-8).
Overall , patients given PE experienced more grade 4 neutropenia and grade 3/4
vomiting, while those on TC experienced more, grade 4 thrombocytopenia, grade
3/4 anemia and diarrhea.A
172.
* Use a surfing filter
* Increase the security level on the web browser
* Secure backups of important data on the PC

For more information on Telenor's security services and relevant
statistics please visit: http://www.

obchod medzin

D.03, 1.

GlaxoSmithKline Forward-Looking Statement
Under the safe harbor provisions of the US Private Securities Litigation
Reform Act of 1995 , the company cautions investors that any forward-looking
statements or projections made by the company , including those made in this
Announcement, are subject to risks and uncertainties that may cause actual
results to differ materially from those projected.000 active e-mail subscribers on
both its Online ADSL and Frisurf platforms, and in the business market.435 WORM_MYDOOM.691 WORM_NETSKY .g.

For more information, please contact:
Head of information Arild S.

rstvo elektronika

, Chairman,
Department of Medical Oncology, Montefiore Medical Center, and Gutman
Professor of Medicine, Albert Einstein College of Medicine.4 percent for both
groups. As Norway's largest Internet provider in both the consumer and business
markets, Telenor has taken steps that are likely to reduce the scope of the
virus problem in 2005. For those
Telenor customers who have installed their own spam filter, almost 70 per cent
of all e-mails were blocked as unwanted spam. This radar will continuously analyse the four million e-mail messages
that each day pass through Telenor's virus scan servers.