Disturbances of serotonin and/or norepinephrine may explain the
presence of both the emotional and physical symptoms of depression. Cymbalta is not approved for use in patients under the
age of 18. "Major Depression in the Elderly," Johns Hopkins
University , Spring 2003.

Kentucky Governor Fletcher Proclaims Caffeine Awareness Month

org or contact Marina Kushner at
(815) 572-8007. residents only.

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Anyone considering the use of Cymbalta or any other
antidepressant in a child or adolescent must balance the risk with the
clinical need.
In clinical studies of Cymbalta for depression, the most common side
effects were nausea, dry mouth, constipation, decreased appetite, fatigue,
sleepiness, and increased sweating.com . Available at:
http://www.jsp?userid=10017134

Interviews and
photographs are available by request.

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"Since treating this population is so challenging, the fact that patients
responded to medication within one week while on Cymbalta is promising,"
stated Joel Raskin, MD, FRCPC, medical advisor Eli Lilly and Company. They also showed a numerical
advantage on the anxiety/somatization subscale that was not statistically
significant , as compared with those treated with a sugar pill.
Prescription Cymbalta is not for everyone . People who are allergic to
Cymbalta or the other ingredients in Cymbalta should not take it. Nursing while taking Cymbalta is not recommended.

(i) Kim, Crystal.
Helicor's StressEraser is a handheld medical device designed to calm the
mind and relax the body anytime, anywhere. The
StressEraser is classified by the FDA as a Class II (510(k) exempt) medical
device.com .

About Frost + Sullivan
Frost + Sullivan, a global growth consulting company, has been partnering
with clients to support the development of innovative strategies for more than
40 years.

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Cymbalta also significantly reduced somatic anxiety -- or physical symptoms
often associated with anxiety -- compared with placebo (mean change of 1.Cymbalta.

About Lilly
Lilly, a leading innovation-driven corporation, is developing a growing
portfolio of first-in-class and best-in-class pharmaceutical products by
applying the latest research from its own worldwide laboratories and from
collaborations with eminent scientific organizations. Recognizes the need to reduce caffeine dependency

LEXINGTON, Ky. If you boost
that level to more than 1 gram (1000 mg ), you can get irregular heartbeats,
panic and anxiety disorders, muscle twitching, incoherent speech , excessive
urination, flushed skin, and depression." The book has been described by critics as a "wake-up call" about caffeine
and reveals "frightening evidence" of the damage caffeine can cause .

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lilly. Lilly undertakes no duty to
update forward-looking statements.org/AnxietyDisorderInfor/AnxietyElderly . PALO ALTO, Calif.

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99), according to the anxiety/somatization subscale of the HAMD17.
* In this study, Cymbalta was safe and well tolerated, with
discontinuations due to adverse events occurring in less than 10 percent of
those treated, with no difference between Cymbalta and placebo. In all clinical
trials, most people were not bothered enough by side effects to stop taking
Cymbalta .

Available Topic Expert(s): For information on the listed expert(s), click
appropriate link . Each
time a person has an emotionally charged thought, there is a temporary
inhibition of parasympathetic outflow.
Frost + Sullivan's Award for Technology Innovation of the Year recognizes
Helicor , Inc.

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Significant Reduction in Anxiety Symptoms Seen as Early as One Week

ATLANTA, Ga . Serotonin and norepinephrine are believed to
both mediate core depression symptoms and help regulate the perception of
pain. Patients who are starting therapy should be observed closely.newscom. This
will be the first year that Kentucky is hosting this annual event. The StressEraser can be used to
quiet the mind before sleeping, rapidly relieve intense stress, and even to
stay calm during highly stressful situations. Frost + Sullivan serves an extensive clientele that
includes Global 1000 companies, emerging companies, and the investment
community by providing comprehensive industry coverage that reflects a unique
global perspective and combines ongoing analysis of markets, technologies ,
econometrics, and demographics. For more information, visit
http://www.

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, Cymbalta(TM) (duloxetine
HCL) significantly reduced anxiety symptoms in elderly patients with
depression, compared with those treated with a sugar pill, according to new
research presented today at the annual meeting of the American Psychiatric
Association.2 percent), fatigue (6.3 percent). Based on
pre-clinical studies, Cymbalta is a balanced and potent reuptake inhibitor of
serotonin and norepinephrine.
For full Patient Information, visit http://www. There is no guarantee that
the product will prove to be commercially successful.

About Helicor, Inc. Patents are pending.

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This
comorbidity is associated with an increased severity of symptoms, including a
greater risk for suicide, and often less successful treatment outcomes,"
explained Olga Brawman-Mintzer, MD, associate professor of psychiatry , and the
director of Anxiety Disorders Program at the Medical University of South
Carolina.6 percent ), constipation (10.2 percent), diarrhea (8.com/cgi-bin/prnh/20031219/LLYLOGO )

Marina Kushner is the founder."
The aim of emotional stress removal to encourage a steady state of minimal
limbic system activity, which is characterized by the absence of acute limbic
enervation of the autonomic nervous system.

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0.1 percent), headache (7.
At the end of the study, patients entered a one-week, double-blind
discontinuation phase where the dose of the study medication was tapered. Women who are pregnant should talk with their doctor before taking
Cymbalta.jhu.adaa. This
award recognizes the quality and depth of a company's research and development
program as well as the vision and risk -taking that enabled it to undertake
such an endeavor. The StressEraser
is currently available to U.S. Web:
info@stresseraser.

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In the eight-week study of people over age 65 with depression , 60 mg of
Cymbalta, taken once daily, significantly reduced psychic anxiety symptoms in
depressed patients, such as worry, ability to concentrate, tension and
irritability, compared to placebo (mean change 6. 0.
"When anxiety symptoms appear in elderly patients with depression it often
makes treatment more complicated than when these symptoms emerge alone.
While depression alone affects two million Americans aged 65 and
older(i), there is considerable overlap between depression and anxiety. A
secondary analysis was conducted to measure anxiety using anxiety items 10
(psychic ) and 11 (somatic,) and the anxiety/somatization subscale of the
HAMD17.
Patients on antidepressants and their families or caregivers should watch
for worsening depression symptoms, unusual changes in behavior and thoughts of
suicide, as well as for anxiety, agitation, panic attacks, difficulty
sleeping, irritability, hostility, aggressiveness, impulsivity, restlessness,
or extreme hyperactivity ., Frost + Sullivan's 2006
Technology Innovation Award goes to Helicor, Inc. Therefore, the StressEraser uses 'wave by wave' CHP
measurement to observe the activity of the vagus nerve in real-time.
In other words, every time a person has painful or emotional thought,
there will be a temporary inhibition of the vagus nerve. The StressEraser was first
demonstrated at the annual meeting of the American Psychological Association
in August 2005.

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Furthermore, one-quarter of those with anxiety disorders
meet the criteria for major depressive disorder(ii).5 percent), nausea
(12.3 percent ) and somnolence
(5.
Families and caregivers should discuss with the doctor any observations of
worsening depression symptoms, suicidal thinking and behavior, or unusual
changes in behavior . Don't stop
taking Cymbalta without talking to your doctor.Cymbalta. And, believe it or not, when you take
over 5 grams of caffeine, the results can be fatal.
To learn more about Kushner's book, or National Caffeine Awareness Month,
you can visit http://www.

Novel StressEraser Technology Wins Helicor Inc. the Frost + Sullivan 2006 Technology Innovation Award

"The physiological objective of the StressEraser is to attain a sustained
physiological state of parasympathetic dominance ," says Frost + Sullivan
Research Analyst Preethi Vaidyanathan.

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"

Additional Study Highlights
* When elderly patients were analyzed by age:
- Patients under 75 treated with Cymbalta experienced significant
improvements in both psychic anxiety symptoms, such as worry and tension , and
physical anxiety symptoms, as measured by the anxiety/somatization subscale,
compared with those treated with a sugar pill.
* The most common (>/= 5 percent) adverse events experienced by patients
treated with Cymbalta in this study included dry mouth (14. By monitoring real-time CHP, the
StressEraser can detect when that happens and respond appropriately. for developing a stress relieving device technology that
simultaneously aids in the attainment of physiological, mental, and emotional
relaxation.

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Talk with your doctor before taking Cymbalta if
you have liver or kidney problems, glaucoma or consume large quantities of
alcohol. Brief Overview of Anxiety
Disorders . But, with as little as 200 mg of caffeine, you can
experience typical addictive symptoms such as irritability, restlessness,
tension, insomnia, excitement, and gastrointestinal disturbance.prnewswire . The StressEraser uses a proprietary implementation of the
Consecutive Heart Period (CHP) to measure vagal activity.2450
Stacie.

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2 vs. If you have
recently taken a type of antidepressant called a monoamine oxidase inhibitor
(MAOI), are taking thioridazine or have uncontrolled narrow-angle glaucoma ,
you should not take Cymbalta.caffeineawareness.com/ud_public. "The mental objective works in
conjunction with the physiological objective to sustain an inward attention or
present moment awareness, devoid of mental distraction.

Contact:
Stacie Jones
210.

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Half
of those with major depressive disorder actually meet the criteria for an
anxiety disorder.2 percent), dizziness
(8. After one week, patients were randomly chosen to receive
either Cymbalta 60 mg once daily (n=207) or placebo (n=104) for eight weeks.
In clinical studies of Cymbalta in these patients, the most common side
effects were nausea, sleepiness, dizziness, constipation, dry mouth, increased
sweating , decreased appetite, and loss of strength or energy. Your doctor may periodically check your blood pressure." The event is sponsored by the Caffeine Awareness
Alliance, a non-profit organization, who is committed to the physical, mental,
and emotional wellness of the public whose lives have been affected by their
misuse of, or dependency on, caffeine.
Kushner, a reformed coffee drinker , stated, "Most caffeine addicts have no
idea that they are addicts. This is one addiction you
want to kick quickly!" In addition, she added, "I want to thank Governor
Fletcher for his support and wish him a speedy recovery.
Several peer reviewed clinical studies indicate that CHP measurement
(computed from the beat-to-beat heart rate) has a linear correlation with the
level of vagal activity .
"This study is aimed at determining whether the StressEraser can be
successfully integrated into standard group psychological treatment for
individuals diagnosed with generalized anxiety disorder (GAD), and it will
examine whether use of the StressEraser differentially affects symptoms in
comparison with standard relaxation methods.

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"Further research into the benefit of Cymbalta in anxiety is needed . For further discussion
of these and other risks and uncertainties, see Lilly's filings with the
United States Securities and Exchange Commission. Available at
http://www."
Kushner strives to educate consumers through her book, "The Truth About
Caffeine - How Companies That Promote It Deceive Us and What We Can Do About
It.com

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While the mechanism of action of Cymbalta is
not fully known, scientists believe its effect on both emotional symptoms and
pain perception is caused by increasing the activity of serotonin and
norepinephrine in the central nervous system .
Cymbalta is approved in the United States for the treatment of major
depressive disorder and the management of diabetic peripheral neuropathic
pain, both in adults. As Cymbalta has not been studied in children, Lilly discourages
its use in those under the age of 18. Headquartered in
Indianapolis, Ind.pdf . This causes the
real-time CHP measure to drop to near zero. The company 's industry expertise integrates growth consulting,
growth partnership services, and corporate management training to identify and
develop opportunities.

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18), as measured by
the psychic anxiety question on the Hamilton Depression Scale (HAMD17). Cymbalta is not specifically indicated for geriatric
depression .com/.
Governor Fletcher, in his proclamation, stated "there are factors which
are known to reduce the risk for caffeine dependency and play an important
role in prevention."
The company is also working on expanding the device capabilities to
successfully treat a specific list of stress -related conditions.jones@frost.

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New Analysis Shows Cymbalta Reduced Anxiety Symptoms in Elderly Patients with Depression

About Cymbalta
Serotonin and norepinephrine are two chemicals in the brain and spinal
cord called neurotransmitters.com .
(ii) Anxiety Disorders Association of America., Governor Ernie Fletcher has issued
a proclamation declaring March 2006 as National Caffeine Awareness Month.
StressEraser works by measuring the influence of the vagus nerve (the
primary nerve of the parasympathetic nerves) on heart rate.frost.

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for developing the
breakthrough 'StressEraser' device technology. The vagus
nerve has two primary inputs into it: respiration (through respiratory sinus
arrhythmia) and the limbic area of the brain (the emotional processing center
of the brain). Furthermore,
Helicor has filed multiple patents dealing with the internal technology such
as determining sustained parasympathetic outflow from heart rate variability
data, the external form factor, screen display, and the organized presentation
of data.
The StressEraser is available for $299, with a 60-day risk-free trial,
from the StressEraser web site at http://stresseraser.com . Phone: 212-255-5991; Fax: 212-255-5994.

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88
vs.
- Patients 75 and older treated with Cymbalta showed significant
improvements in psychic anxiety, as well.
* A statistically significant improvement in the somatic anxiety item of
the HAMD17 was not seen in patients treated with Cymbalta . Call the doctor if you have thoughts of suicide, or
if any of these symptoms are severe or occur suddenly. However, as with
any pharmaceutical product, there are substantial risks and uncertainties in
the process of development and commercialization. Intended for use by licensed
psychological and psychiatric health care professionals, this handheld
relaxation-training device is able to provide effective relief from chronic
stress at the physiological, mental, and emotional level.
Each year Frost + Sullivan presents this award to a company (or
individual) that has carried out new research which has resulted in
innovation(s) that have or are expected to bring significant contributions to
the industry in terms of adoption, change, and competitive posture. The vagus nerve
extends from the brainstem to many organs, including the heart.

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Important Safety Information
In clinical studies, antidepressants increased the risk of suicidal
thinking and behavior in children and adolescents with depression and other
psychiatric disorders.
For full Prescribing Information , including Boxed Warning, visit
http://www. Accessed 1/5/05.cfm .
Marina Kushner
http://profnet . First customer shipments began in October 2005.

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Cymbalta is also approved for the
management of neuropathic pain associated with diabetic peripheral neuropathy., Lilly provides answers -- through medicines and
information -- for some of the world's most urgent medical needs. Accessed March
21 , 2005.

(Logo: http://www.
"Helicor is currently completing contractual arrangements with the
American Psychological Association Practice Organization to conduct the first
clinical study that will compare the relaxation training efficacy of the
StressEraser to standardized relaxation training methods," notes Vaidyanathan.
Helicor's corporate headquarters is located at 156 Fifth Avenue , Suite 1218,
New York, NY 10010.247.

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Methods
Data were gathered from 311 patients with major depression aged 65 and
older who participated in a multicenter, parallel, double-blind , placebo-
controlled study. Be especially
observant at the beginning of treatment or whenever there is a change in dose. Additional
information about Lilly is available at http://www.

P -LLY

This press release contains forward-looking statements about the potential
of Cymbalta hydrochloride for the treatment of anxiety, in addition to major
depressive disorder, and reflects Lilly's current beliefs.edu/hurj/issue2/07C%20MajorDepress. The book
exposes the serious physical and psychological effects of caffeine and the
damaging effects it has to your health.com .

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- - kjjkjk

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