The Firm's revolutionary product is doubly
patented for use as an active drug and as a low-calorie sweetener in drugs to
increase their palatability. Using FDA-approved plaque -measuring
techniques, the investigators will monitor and compare the effects of a
Naturlose mouth rinse, a water mouth rinse, and a standard plaque-reducing
chemical mouth rinse on the teeth and gums. Naturlose is already approved as
"non-cariogenic" by the FDA. Spherix initially
developed it for its low-caloric properties and its table sugar-like taste. It
also offers those parents living in low-fluoridated communities an alternative
to fluoride supplements.ko.
As advocates of children's oral health, the AAPD works closely with the
AAPD Foundation, legislators, professional associations and health care
professionals to develop policies and guidelines, implement research
opportunities in pediatric oral health, and educate pediatric dentists, health
care providers and the public regarding pediatric oral health.com . Food and Nutrition Board, Institute of Medicine . You can't miss it -- it's the one
that looks like a school bus!

4.org.

brush agincourt

This would permit the BioSpherix Division to
become a virtually independent, self-supporting company.(1) It affects
more than one fifth of American children aged 2-4, half of those aged 6-8 and
nearly 60 percent of those aged 15.

agincourt lifetime

The data, if supporting the earlier results, would then be submitted
to the FDA for approval of Naturlose as a drug for use in oral hygiene
products. This same strategy prompted the research project(4) we funded
at the Albert Einstein College of Medicine to determine whether Naturlose
might increase the shelf life of blood, blood components, and medicinal
proteins as independently reported by researchers at this leading blood
research institution."
Richard C.com/newsstory.25 mg F/day
1 bottle of Spring!
Ages 3 - 6 0.aapd.

About Spring! by Dannon Fluoride to Go
Spring! by Dannon Fluoridated Spring Water originates from protected
springs and is bottled with minimal processing by CCDA Waters.L.

prepare gfg

The BioSpherix Division could then make claims that its recently
developed(3) mouthwash and toothpaste formulations made with Naturlose prevent
and destroy plaque and attack the common gum disease of gingivitis. We are currently considering additional
clinical trials with various research institutions and universities for other
significant medicinal properties that we have patented for Naturlose. FDA regulations, indicated a number of drug
properties(6) for the simple, but rare natural sugar. Factors that could cause actual
results to differ materially from those expressed or implied include, but are
not limited to, those discussed in filings by the Company with the Securities
and Exchange Commission, including the filing on Form 8-K made on March 3,
1999.
(2) Lu, Y, "D-Tagatose, a Novel Humectant and Sweetener for Toothpastes,"
Cosmetics + Toiletries 116, 5, 95-100, 2001.
(4) Spherix Incorporated Press Release, "Naturlose May Extend Blood Shelf
Life," July 22, 2004.

Parents and children will receive information about the importance of fluoride
in their fight against cavities.00 mg F/day
4 bottles of Spring!
Over 16 years 1. Your child may think they're old enough to brush their
own teeth, but until they reach the age of six, make sure to take
command and brush their teeth for them at least twice a day, using a
pea-sized amount of ADA-approved toothpaste.

SPRING!, the Spring Coil , and the Splash designs are trademarks of The
Coca-Cola Company.

preschoolers prepare

Dr. H. Studies by the Centers for Disease Control and Prevention
reaffirm the benefits of community water fluoridation and found that for
larger communities, every $1 invested in this preventative measure yields
approximately $38 savings in dental treatment costs.5 mg F/day
2 bottles of Spring!
Ages 6 - 16 1.

EDITOR'S NOTE: Tips by the AAPD to prevent tooth decay and a product
photo are available, please email rcrockett@na. For a product photo please e-mail
rcrockett@na.ko.

shaped celebrate

They demonstrated
Naturlose's ability to prevent oral bacteria from forming plaque, and to
destroy any plaque already formed. "Our Fluoride to Go bottles are kid-sized and
clearly marked with fluoride levels to help parents ensure their kids are
getting the right amount to keep teeth strong and healthy. For more information about Dannon Natural Spring Water, please visit
our website at http://www. http://www. Despite recent improvements in dental care in the United
States, tooth decay is still one of the most common childhood diseases . Tooth care starts with the first tooth -- brush your baby's
gums and emerging teeth gently after each feeding with a toothbrush
designed for infants and toddlers.

dentist fairy

Spherix has patents pending for these uses.
Dr. Levin, a veteran Spherix Officer recently elected as CEO and
President , said, "The placement of clinical trials and other research
activities in major universities is part of our plan to jump-start the
BioSpherix Division into a highly value-added position.org
(2) National Health and Nutrition Examination Survey, 1999-2000.(A) It affects more than one
fifth of American children aged 2-4, half of those aged 6-8 and nearly 60
percent of those aged 15. After age six, continue to
supervise brushing to make sure they reach every tooth and brush
properly. If you're among
the 40 percent of families without optimal levels of fluoridation in
your municipal tap or well water, talk to your dentist about
fluoridation options . Don't Forget in Between. You will have to floss for them;
it's the only way to reach lingering food particles lurking between
your child's teeth.C.

toothbrush cassette

If the results are as the Company expects, additional clinical trials will
be run.
Spherix licensed its product for use as a sweetener in foods and beverages to
Arla Foods of Denmark, which sells it under the brand name Gaio-tagatose (R) to
brand food product manufacturers, including PepsiCo (in Diet Pepsi Slurpee's),
and to a variety of companies incorporating the sweetener into beverages,
chocolate confections and other products.spherix.(4)
"Drinking water with fluoride is still the easiest and most effective way
to fight tooth decay," said AAPD president Dr.
Spring! by Dannon Fluoride to Go Fluoridated Natural Spring Water has
60 percent share of the fluoridated water market and is growing faster than
the youth-sized water segment.(7) It is available with or without fluoride in
single serve, kid-sized 8.

Five Tips to Help Kids Take a Bite Out of Tooth Decay

Dentists across the country will be working together this month to educate
parents and children about better dental care in honor of National Children's
Dental Health Month. A Good Cleaning. If you prefer your kids to drink bottled water,
be aware that not all waters contain optimal fluoride levels and make
sure it's clearly labeled "with fluoride." Spring! by Dannon
Fluoride (TM) to Go(R) Spring Water, which has 0.C.

preschoolers brush

(3) Spherix Incorporated Press Release, "Spherix Shareholders Elect Board
Members; Prototype Samples of Naturlose(TM) Toothpaste and Mouthwash
Unveiled," May 20, 2004. Pitts Hinson."(5)
"Parents who prefer bottled spring water to keep their kids healthy and
hydrated now can choose the convenience of bottled water, confident that they
are also providing essential fluoride," said Deb Roberts, senior brand
manager, Spring! by Dannon .dannonwater.

3. Eat Well.

For more dental care tips and information about safe fluoridation levels,
visit http://www.

(A) ADA Fluoridation Facts, 2005.

holder agincourt

In the clinical trials, people known to form dental plaque will be chosen
as subjects. Cos. The AAPD's over 6,000
members are primary care providers who also provide comprehensive specialty
treatments for infants, children, adolescents and patients with special health
care needs.org ., used under license by CCDA Waters, L.C. Visit a dentist as soon as your baby's first tooth
appears and no later than age one.

brushing cassette

and G.
Today, dental decay is still one of the most common childhood
diseases -- five times as common as asthma in 5-17-year-olds.25 mg of fluoride added. For further
information , please visit http://www. JADA, Vol.

The American Academy of Pediatric Dentistry (AAPD ) has reviewed this
material to ensure scientific accuracy. Drink Fluoridated Water.

puppet kindergartens

Spherix Starts Clinical Trials of Naturlose as Oral Plaque Fighter

It also permits them to support the Division 's efforts to
sell Naturlose as a sweetener to oral care, pharmaceutical, and cosmetic
companies for use in their products. We believe that
success of these studies will attract pharmaceutical companies and other
organizations to fund the costly New Drug Application procedures required to
gain FDA approval for drug uses.

Under its motto, "A World of Solutions," Spherix's mission is to create
value and increase shareholder wealth through innovations that benefit our
clients and the human condition. 24, 225-234, 2002.3 mg of
fluoride in the municipal drinking water .25 mg of fluoride in one 8.
(3) Study findings indicate that Americans consumed more than 5 million
gallons of bottled water in 2000, more than double the amount a decade
earlier .
(6) Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin
D, and Fluoride. Visit your Dentist. Your
baby's first teeth are beautiful and cavity-free, regular visits can
help keep them that way and could save you a lot on dental care.aapd.

toothbrush dentist

At the start of the trial, their plaque levels will be reduced
to zero by mechanical dental procedures . The tests will be performed to
FDA standards. A new look, including the
updated name, "Spring ! by Dannon", will be in supermarkets beginning next
month. "Fluoride to go" is a
registered trademark of CCDA Waters, L. It is
five times as common as asthma in 5-17-year-olds. Make sure your child eats a balanced diet, stays hydrated,
and seeks healthy options for between-meal snacks. http: //www.

hygiene tooth

They will be instructed to use only the given
mouth rinse, with no tooth brushing, flossing , or other plaque removal
technique for the multiple test periods as prescribed by the University of
Maryland School of Dentistry investigators.org .

Children Recommended Daily Fluoride Intake *
Ages 6m - 3 0.

SPRING!, the Spring Coil, and the Splash designs are trademarks of The
Coca-Cola Company. National
Center for Health Statistics, CDC. However, this does not imply
endorsement of Dannon products. Water fluoridation can prevent up to
40 percent of tooth decay.25 mg of fluoride in
every 8.5 fl oz bottle -- the level recommended by the AAPD -- comes in
a perfect size for your little ones . "Fluoride to go" is a
registered trademark of CCDA Waters, L.

celebrate hygiene

We recently sold(7) Naturlose to a major
U. Book routine visits for professional
cleanings and check ups as recommended by your child's dentist. A toothbrush can't get into every nook and
cranny so it's important to floss. DANNON is a registered trademark of The DANNON Company,
Inc., used under license by CCDA Waters, L.

dentist shaped

BioSpherix believes that the trials, being conducted
by the University of Maryland School of Dentistry, will provide human
validation of the Firm's own laboratory tests(1,2). Gilbert V. Levin , Spherix's Executive Officer for Science, said, "This
is a very important development in line with our newly declared business plan
to invest in hastening the commercialization of the higher value applications
of Naturlose. Because such
statements include risks and uncertainties, actual results may differ
materially from those expressed or implied. J. Sci.asp?id=71401, March 14, 2005.V., "Tagatose , the New GRAS Sweetener and Health Product,"
Journal of Medicinal Food 5, 1, 23-36, 2002 . 134, September 2003
(4) AAPD, 2003-2005, http://www.aapd.

nurseries brush

S."

Certain statements contained herein are "forward looking" statements as
defined in the Private Securities Litigation Reform Act of 1995. Spherix offers innovations in information
technology, knowledge management, and biotechnology .
(6) Levin, G.
(7) Spherix Incorporated Press Release, "Spherix Announces First Sale of
Naturlose(TM) for Pharmaceutical Use," October 14, 2004. "In fact,
communities with an optimal level of fluoride in their municipal water supply
experience a 20 - 30 percent reduction in decay, which can translate into
significant financial savings in dental expenses and a lifetime of
maintenance. Spring! by Dannon
Fluoridated Spring Water contains our recommended level of fluoride, making it
easy for parents to give their kids the right amount to beat tooth decay.00 mg F/day
4 bottles of Spring!

* serving size based on one 8.5 fl oz glass of fluoridated water or one
8.L.L.ada.
(7) AC Nielsen 2005, annual supers, mass and drug.com or jen@relishminds. However, this does not imply
endorsement of Dannon products.

toothless gfg

Furthermore, plaque in other parts of the body has
been implicated in a variety of other health problems. For further
information about the Spring! by Dannon Fluoride to Go and AAPD fluoride
education campaign and tips on how to prevent tooth decay, visit
http://www.5 fl oz bottles with sports bottle tops and sold at
grocery stores and mass retailers nationwide.

5.ada.org
(B) National Health and Nutrition Examination Survey, 1999-2000.
(C) ADA eGram, July 22 , 2005

The American Academy of Pediatric Dentistry (AAPD) has reviewed this
material to ensure scientific accuracy.

toothpaste prepare

The subjects will not know which
mouth rinse they are using."
There has been much recent emphasis(5) on the importance of preventing and
removing dental plaque to protect the teeth and gums, and, thereby, to ward
off serious oral disease.biocompare.5 fl oz bottle of Spring! by Dannon Fluoridated Spring Water with
0.com or
jen@relishminds.com

About the AAPD
Founded in 1947, the AAPD is a non-profit membership organization
representing the specialty of pediatric dentistry.(B) Dr. Do not put your
child to bed with a bottle containing anything but water, and encourage
use of a cup as their first birthday approaches.

toothbrush keepsakes

Several of these applications are under active development by the
BioSpherix Division, operating in its new laboratory and office facilities in
Annapolis, Maryland. Levin, "Removal and prevention of dental plaque with D-
tagatose," Int.

UPDATE: Nation's Dentists Get Behind Fluoride Awareness Campaign for Kids

aapd.

How Much Fluoride?(6)
Parents should consult their dentist regarding fluoride intake. This table assumes less than 0. DANNON is a registered trademark of The DANNON Company ,
Inc.

2.(C) Drinking water with fluoride is still the
easiest and most effective way to fight tooth decay. National
Center for Health Statistics, CDC.

holders nurseries

Levin continued, "Our university research adds great
strength to our Division, freeing our scientists to explore new applications
of our technology.S. A Spring! by Dannon product coupon will also
be included. H.L.

kindergartens dentist

Animal and human
studies of Naturlose, that established it as a substance Generally Recognized
As Safe (GRAS ) under U.

Spherix's Internet address is http://www.com. American Academy of Pediatric Dentistry and Spring! by Dannon Fluoride to Go
Launch Education Initiative for National Children 's Dental Health Month

ATLANTA, In honor of National Children's Dental
Health Month in February, more than 6,400 members of the American Academy of
Pediatric Dentistry (AAPD) will kick off a national campaign in partnership
with Spring!(TM) by Dannon(R) Fluoride to Go(TM) to help focus attention on
the importance of drinking water with fluoride for children. Up to 1 mg of
fluoride per liter of water is added according to optimal level guidelines
recommended by the AAPD, equaling 0.

1.

keepsakes brush

, The BioSpherix
Division of Spherix Incorporated (Nasdaq: SPEX), a technology firm
headquartered in Beltsville, Maryland, today announced human clinical trials
had begun to test Naturlose(TM), the Firm's unique, naturally-occurring sugar,
in fighting oral plaque. Success in either of these endeavors will elevate
Naturlose to a new order of value.
Spherix retains the rights to all non-food uses of its extraordinary
discovery. pharmaceutical company for clinical trials, which, if successful, could
result in the product's first pharmaceutical use.

(1) Lu, Y.
(5) "Strategies For Combating Bacterial Biofilm, A Leading Cause Of Gum
Disease, Explored At IADR Symposium,"
http://news."
The national awareness campaign will start with the distribution of
educational activity books at pediatric dental offices and clinics nationwide. Spring! by Dannon Fluoride to Go is an easy and fun way to help
youth drink more water and get the recommended level of fluoride. The
following schedule can be used as a discussion tool . Pitts Hinson, president of the American
Academy of Pediatric Dentistry (AAPD), offers these five simple tips to help
you and your kids in the fight against tooth decay.com.

fairy shaped

BELTSVILLE, Md. The
Company could offer those products for license, or could license and sell
Naturlose, itself, to oral care manufacturers for use in their own brands.5 fl oz bottle.org
(5) Centers for Disease Control and Prevention, August 2001: Cost Savings
of Community Water Fluoridation.

gfg kindergartens

(2) The awareness campaign recognizes that
children in the United States may not be getting enough fluoride to fight
preventable tooth decay due to the dramatic rise in consumption of bottled
waters,(3 ) and the fact that 40 percent of children do not have optimal levels
of fluoride in their local water supply.C.

(1) ADA Fluoridation Facts, 2005.