DC Doctors Make Dream of a Good Night's Sleep a Reality With New Procedure

Pillar(R) Implant Procedure Provides Low-Risk Treatment
for Snoring and Sleep Apnea - in One Office Visit

WASHINGTON, The practice of Feldman Oringher
Dettelbach Mesick Schoenfeld Otolaryngology, PC is pleased to announce it is
now accepting patients for a breakthrough treatment for snoring and sleep
apnea, the Pillar (R) Implant procedure. Oringher has been specializing in snoring and sleep disorders and
endoscopic sinus surgery for chronic sinusitis for 15 years. Dr.

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Sleep apnea is defined as an interruption of breathing during sleep.

com. Approved products include Naglazyme(TM) (galsulfase) for
mucopolysaccharidosis VI (MPS VI), a product wholly developed and
commercialized by BioMarin, Aldurazyme(R) (laronidase) for
mucopolysaccharidosis I (MPS I), and Orapred(R) (prednisolone sodium phosphate
oral solution) for inflammatory conditions. and is
used under license.

occasional sleep

The Pillar Implant procedure is the only
implantable treatment approved by the Food and Drug Administration (FDA) for
mild to moderate OSA.

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Patients with untreated OSA are at higher risk for heart disease,
high blood pressure, stroke, memory problems, weight gain, impotency and
headaches.
Oringher's peers perennially vote him among WASHINGTONIAN Magazine's TOP
DOCTORS.

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"Many complaints of daytime fatigue can be attributed to snoring and sleep
apnea," noted Dr.
Left untreated, this condition has a serious impact on the long-term health of
sufferers. He earned
his medical degree at George Washington University School of Medicine and
completed his residency at the prestigious Cleveland Clinic Foundation. Patients may choose
from three convenient locations: Chevy Chase and Germantown , Maryland and
Washington, DC.

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BioMarin to Present at Cowen + Co. 26th Annual Health Care Conference

A replay of the
presentation will be archived on the site for at least one week following the
presentation.com.

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26th Annual Health Care Conference in Boston on Tuesday, March 7,
2006 at 3:10 p. The company's product portfolio is
comprised of three approved products and multiple product and preclinical
product candidates. BioMarin Pharmaceutical Inc.

masking sleep

I sought a different
treatment and found a safe and effective way to address sleep apnea and
snoring problems with the Pillar Implant procedure.
The Pillar Implant procedure is performed in the physician's office during
a single , short visit under local anesthesia.m.
415-506-6777 415-506-6701

mask conditioners

With Pillar I'm able to
offer patients a one-time, in-office procedure that offers relief from the
effects of OSA and snoring.

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Oringher and Feldman Oringher
Dettelbach Mesick Schoenfeld Otolaryngology, call (301) 652-8847 or visit us
at http://www.e-n-t.
Interested parties may access a live audio webcast of the presentation via
the investor section of the BioMarin website , http://www.

sleepless sleeplessness

Oringher joined Feldman Oringher Dettelbach Mesick Schoenfeld
Otolaryngology in 1991 and is dedicated to providing patients with safe,
efficacious treatments for snoring and sleep disorders . NOVATO, Calif, BioMarin Pharmaceutical
Inc.

neighbours noise

This new treatment offers patients a
simple , one-time, in-office alternative to surgery or life-long mask therapy. He appears regularly on television and radio as an
expert on the topics of snoring, sleep, sleep apnea and sinusitis.BMRN.

sleepwell windchimes

Information on BioMarin's website is
not incorporated by reference into this press release.

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To learn more about Dr.BMRN.

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Orapred(R) is a registered trademark of Medicis Pediatrics, Inc.

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"But most OSA patients are reluctant to wear a
CPAP mask at night or to undergo major surgery.

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"
The best-known symptoms of sleep apnea are snoring and daytime fatigue.

NOTE: Aldurazyme(R) is a registered trademark of BioMarin/Genzyme LLC.

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He has
accreditation from the American Academy of Otolaryngology-Head and Neck
Surgery, the American Rhinologic Society, the American Sleep Disorder
Association, and is a Fellow of the American College of Surgery.
Dr.

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During the procedure, the
physician places three inserts in the patient's soft palate, causing the
palate to stiffen. Most patients report that the
procedure is virtually painless and that they are able to resume normal
activities and diet the same day. He also consistently ranks very high among leading DC metro area
physicians in the Washington Consumers' CHECKBOOK, an unbiased non-profit
consumer ratings service. (Nasdaq and SWX: BMRN) today announced that Jean-Jacques Bienaime, Chief
Executive Office of BioMarin, will present a company update at the
Cowen + Co.

About BioMarin
BioMarin develops and commercializes innovative biopharmaceuticals for
serious diseases and medical conditions.

Contacts:

Investors Media
Joshua A.

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The
most common cause of obstructive sleep apnea (OSA) and snoring is due to a
blockage in the throat that prevents proper airflow, causing sufferers to wake
up hundreds of times throughout the night.com. ET. Grass Susan Ferris
BioMarin Pharmaceutical Inc.

sleep supplement

Dr. Investigational product candidates
include Phenoptin(TM) (sapropterin dihydrochloride), a Phase 3 product
candidate for the treatment of phenylketonuria (PKU).

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In nearly 80 percent of patients suffering from sleep apnea and
snoring the soft palate is believed to be the site of obstruction, causing
this serious problem. The stiffening helps to prevent or lessen blockages of the
airway -- effectively treating snoring and/or sleep apnea. The Pillar inserts
are less than one inch long and made from a woven soft polyester material that
has been used for many years in implantable medical products.

mask supplement

Oringher.
The Pillar Implant procedure is designed to stiffen the soft palate in
order to aid air flow and prevent the obstruction. For additional
information, please visit http://www.