Barrier's
performance and financial results could differ materially from those
reflected in these forward-looking statements due to the outcome of future
clinical trials, the decisions of regulatory authorities, general
financial, economic, regulatory and political conditions affecting the
biotechnology and pharmaceutical industries generally. Ingredients Can Hide Flaws, Add Color , Protect Skin Against the Sun and More

SAN FRANCISCO, Moisturizer is one of the most
effective and versatile cosmetics on the market. "You also should put moisturizer on your
hands after every time you wash them to help minimize water loss.aad.

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The results from
the analysis of the Rambazole treated skin compared to vehicle treated skin
showed strong dose dependent activity with changes of 10 to 1000 fold for
these biological markers as compared to baseline, whereas virtually no
changes were seen in the vehicle treated skin. The Company is developing
an oral formulation of Rambazole for the treatment of psoriasis and severe
acne, as well as a topical formulation for psoriasis, acne , and wrinkles.

About Barrier Therapeutics, Inc. The Company currently markets Solag
(mequinol 2%, tretinoin 0.

In the current marketplace, all facial moisturizers are formulated
to not clog pores, cause acne or an allergic reaction. Moisturizers for
oily skin usually are very light and primarily use dimethicone as their active
ingredient.
"Petrolatum is still the gold standard to which all other moisturizer
ingredients are compared," Dr.

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Rambazole is a novel retinoic acid metabolism-blocking agent (RAMBA).,
Chairman and Chief Executive Officer of Barrier Therapeutics , Inc. "In
addition, the biomarker findings with topical Rambazole may also open the
therapeutic door to an effective and non-irritating alternative to the
widely used topical retinoic acid products and their derivatives for
dermatological indications such as acne and photo-damage."

Dr. Forward-looking statements provide
Barrier's current expectations or forecasts of future events.

, clinical associate professor
in the department of dermatology at Wake Forest University School of Medicine
in Winston-Salem, N.

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In
Barrier's recently completed Phase 2a trial with its oral formulation of
Rambazole, 17 subjects with moderate-to-severe acne were treated with 1 mg
of oral Rambazole once daily for 12 consecutive weeks. The Company is headquartered in
Princeton, New Jersey and has wholly owned subsidiaries in Geel, Belgium
and Ontario, Canada.C. Lipsticks also contain ingredients that offer the consumer color,
coverage, sun protection and moisture at the same time.
Creams that are formulated for hands typically use a combination of
ingredients such as petrolatum, glycerin , dimethicone and/or mineral oil.org.

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Non-serious side effects experienced by this patient group
included some dryness of skin and lips. These
results further build on our previously announced promising clinical data
for oral Rambazole for psoriasis," stated Geert Cauwenbergh, Ph. Studies to date
suggest that Rambazole is more selective and more active than Barrier's
first generation RAMBA-based product candidate. Barrier has product
candidates in earlier stages of clinical development for the treatment of
acne, psoriasis and fungal infections.com.

Moisturizers Do More Than Just Soften Your Skin

Depending on its
ingredients, it can soften and soothe the skin on your face, body and hands,
while also protecting it from the sun and camouflaging its imperfections. Moisturizers for normal skin are usually
lighter and contain such silicone-derived ingredients as dimethicone,
cyclomethicone and lightweight oils such as cetyl alcohol. Draelos said.

Lip Balms and Lipsticks
Lips tend to dry out faster than the rest of your skin because they
contain very few oil glands.

treatable seborrheic

Skin biopsies were taken and analyzed
for three key biological markers that are known signals for potential
therapeutic effect when topical retinoids are applied.

About Rambazole

Rambazole is Barrier's second product candidate based on the Retinoic Acid
Metabolism Blocking Agent (RAMBA) class of molecules. "Their primary
function is to keep skin moist, minimize wrinkles from dryness, smoothe and
soften skin, and to deliver other ingredients, like sunscreen, that benefit
the skin.
People may feel that they're 'addicted' because they enjoy the feeling of
smooth, moisturized lips.

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07% concentration or a
0.35% concentration and its vehicle.
Speaking today at the 64th Annual Meeting of the American Academy of
Dermatology, dermatologist Zoe D. Traditionally, lip
balms have been made from petrolatum and wax.

ontos acne

Dr.

Web site: http://www.
Moisturizers for dry skin are comprised of ingredients like mineral oil,
petrolatum, glycerin and cyclomethicone, all of which are thick and physically
prevent water loss from the skin."
Lipstick is basically lip balm with added color. Manufacturers use less
stiff waxes, like carnauba or candela, to make them glide smoothly over the
lips.

Products which deal with problems for skin: Conditions, Diseases and Flaws.

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Inflammatory and non-inflammatory lesions responded equally
well to treatment., the American Academy of Dermatology
(Academy), founded in 1938, is the largest, most influential, and most
representative of all dermatologic associations. For more information, contact the Academy at
1-888-462-DERM (3376 ) or http://www.

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Barrier also conducted a double-blind, vehicle controlled study with its
topical formulation of Rambazole in which each of 15 healthy volunteers
were treated for 9 days with both the drug at a 0.01%) Topical Solution in the U."

Facial Moisturizers
Facial moisturizers are designed for use in the morning, following
cleansing.
When looking for a facial moisturizer that contains sunscreen, it is
important to select one that offers protection from ultraviolet (UV ) A rays
which can cause long-term damage to the skin's underlayers, resulting in
wrinkling and other aging effects.
"Lip balms also are formulated to provide a smooth feel to the lips," Dr . When DHA is applied to the skin, it creates a reaction that
turns the skin brown. Draelos noted that the cosmetics industry continually develops new
moisturizer formulations, adding new ingredients that benefit the skin and can
save the consumer time.

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Barrier Therapeutics, Inc. There were no serious treatment-related adverse effects
reported.

Barrier Therapeutics, Inc. Today, products like
dimethicone, a skin protectant, and sunscreen have been added to many of the
lip balms on the market. With a membership of more
than 15,000 physicians worldwide, the Academy is committed to: advancing the
diagnosis and medical, surgical and cosmetic treatment of the skin, hair and
nails; advocating high standards in clinical practice, education, and research
in dermatology; and supporting and enhancing patient care for a lifetime of
healthier skin, hair and nails.

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barriertherapeutics . New products will soon offer ingredients
that block UVA rays chemically and provide longer-lasting protection.

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The levels of biomarkers
obtained with the 0.35% concentration of the topical Rambazole formulation
are equivalent to those reported in the literature for currently marketed
concentrations of topical retinoic acid. "It's important to understand your skin type when selecting a
moisturizer so that you get the full benefit of the product," Dr.
Facial moisturizers also may contain sunscreens and foundation, making
them great multi-tasking products for women with hectic schedules.

Body Lotion
Body lotions are usually made from a mix of water, mineral oil,
dimethicone and glycerin. Draelos said.
They go on thickly to help create an artificial barrier against water loss and
to protect the skin from further damage.

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D. Given these
risks and uncertainties, any or all of these forward-looking statements may
prove to be incorrect. Barrier undertakes no obligation to update publicly
any forward-looking statement. Draelos, M. Draelos.

oily cleansers

(NASDAQ: BTRX), a
pharmaceutical company developing and commercializing products in the field
of dermatology, today reported positive Phase 2a data for its oral
formulation of Rambazole in the treatment of moderate to severe acne
and positive biological activity data for its topical formulation of
Rambazole. In addition, none of the
volunteers had signs of irritation after application of topical Rambazole
or its vehicle.

Safe Harbor Statement

In addition to historical facts or statements of current condition , this
press release contains forward-looking statements within the meaning of the
"Safe Harbor " provisions of The Private Securities Litigation Reform Act of
1995, including statements regarding the future development of Rambazole,
the potential safety and efficacy of Rambazole, if approved , and the
commencement of future clinical trials. Draelos
noted. "You can
cover flaws, protect yourself from the sun and keep your skin soft and
younger-looking with one step," Dr. Draelos.

mellifera acne

com for up to 90 days. The differences are in
how they are created to work with different skin types and whether they have
additional beneficial ingredients.

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Cauwenbergh is scheduled to present this data as part of an update to
the investment community at Barrier's 1st Analyst and Investor Day on
September 20th, 2005. and Canada for
the treatment of solar lentigines, a common condition also known as "age
spots," and recently obtained the Canadian distribution rights for
Vaniqa (eflornithine hydrochloride) Cream 13. Barrier has eight product candidates in
various stages of clinical development .
Draelos said.

mellifera psoriasis

"While some people believe that you can become 'addicted' to
lip balm, there is not anything in the actual product that is addictive.

Hand Cream
The skin on the hands often is exposed to harsh products, like soap and
cleaning supplies, that strip away the natural oils, making the skin much
drier than the rest of the body."
Dr.

neutrogena psoriasis

PRESS RELEASE Barrier Therapeutics Reports Positive Phase 2a Data for Oral Rambazole(TM) in Moderate to Severe Acne

" To be considered "cleared or
almost cleared" a subject must have had more than 90% reduction in total
lesion count .9% for slowing the growth
of unwanted facial hair in women.
"There are four categories of moisturizers: facial moisturizers, lip
balms, body lotions and hand creams," stated Dr.

skinceuticals treatable

"These positive Phase 2a results indicate that oral Rambazole is active in
moderate to severe inflammatory acne, and that depending on the outcome of
future, full scale clinical trials, this drug may one day fill the need for
safe and effective oral treatments for moderate and severe acne.D. Draelos said.
"People who suffer from dry, cracked or chapped hands may find that
applying a heavy moisturizer and then wearing cotton gloves at night can be
very helpful," Dr.

oily kinerase

Now
more than ever , there are moisturizers available to meet almost all of your
skin's needs. Therefore, products to keep them moist must be
thick and prevent water loss as well as add moisture.

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European Phase 2a studies in psoriasis and acne have been completed for the
oral dose form of the drug and Barrier is planning a Phase 2b trial with
oral Ramabazole in psoriasis.

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S. The four most advanced product
candidates include one for the treatment of diaper dermatitis complicated
by candidiasis, which is under FDA review, and three products, which are in
or entering Phase 3 clinical trials for the treatment of seborrheic
dermatitis, onychomycosis, and congenital ichthyosis. For a discussion of
these and other risks and uncertainties that may effect the forward-looking
statements please see the risk factors in our Quarterly Report on Form 10Q,
which is on file with the Securities and Exchange Commission., discussed how the ingredients in today's moisturizers
work. Draelos said. "Because there are such a wide variety of moisturizer
options available, a dermatologist can help you determine which ingredients
will work best for your particular needs," stated Dr.

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The results of this
study indicate that 16 of 17 subjects (94%) experienced a reduction in
total acne lesion count of more than 50% and 6 of 17 subjects (35%) were
considered "cleared or almost cleared. Cauwenbergh 's presentation will be available
live via a webcast and will be archived and accessible through the
Company's website at www.barriertherapeutics. "What's important is that the
lotion is one that you like so that you will keep applying it, because no
moisturizer is effective if it's not used .

acne soothes

is a pharmaceutical company focused on the
discovery, development and commercialization of pharmaceutical products in
the field of dermatology. Newer ingredients may include hyaluronic acid and
ceramide 3, which soothe irritated skin. Manufacturers are now providing
novel approaches to deliver these ingredients to the skin, such as time-
released moisturizers."
Some manufacturers also add dihydroxyacetone (DHA), a sunless tanner, to
body lotions. Three to five percent DHA is needed to tan the skin and
protein often is added to make the color deeper.
"It's important to remember that a sunless tan provides no sun protection
factor (SPF) whatsoever, so it's important to use a broad spectrum (protects
against UVA and UVB) sunscreen of at least sun SPF 15 when you are planning to
be outside," Dr.
Headquartered in Schaumburg, Ill.