New tools for diagnosis have
been developed for primary care settings and are provided with management
recommendations based on latest available evidence.
Chronic obstructive pulmonary disease (COPD), asthma, and allergic
rhinitis are the most common chronic respiratory diseases worldwide, but are
significantly under-diagnosed in primary care.

Pulmicort Respules is a preventive type medicine.

relieve asthma

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Researchers evaluated exacerbation rates during a
12-month period following the first asthma medication prescription.

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Asthma is
the third leading cause of hospitalization among children under the age of
15, and it is the most common chronic medical condition.

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(4)

In the study, 25 percent of children who received nebulized ICS as an
initial therapy had to visit an ED or stay in the hospital at least once
during one year of follow-up, compared to nearly 30 percent who had
nebulized ICS as a secondary treatment, and 40 percent who took it as a
third-line treatment . This will help your child avoid health risks that may be
linked with stopping the use of oral corticosteroids .

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The "IPAG Handbook" has been
developed by a joint task force of primary care physicians and respiratory
specialists to improve global care of three leading chronic respiratory
diseases - asthma, COPD , and allergic rhinitis.

"Pediatric patients who were prescribed nebulized ICS earlier in treatment
had a lower rate of exacerbations," said Kevin Murphy, MD, Clinical
Professor of Pediatrics at the University of Nebraska Medical Center, and
principal investigator in the study.

In clinical studies, the side effects experienced with Pulmicort Respules
and how often they happened were similar to what was experienced with a
non-medicated mist (placebo).

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The IPAG expert panel included the world 's
leading primary care physicians as well as the specialist representatives of
GINA, GOLD and ARIA. IPAG is an important
step in growing cooperation between secondary and primary care towards
improving standards of care for chronic respiratory diseases.(5) Asthma triggers range
from smoke, airborne molds, pollens, dust, animal dander, exercise, cold
air, many household and industrial products, air pollutants, scents or
simple stress.aaaai.

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Wonca Emphasizes the Central Global Role of Family Doctors Caring for Patients With Respiratory Diseases

globalfamilydoctor.org
World Organization of Family Doctors http://www.
Experts are unsure why this is the case, although one potential indicator
is the lack of awareness and education about childhood asthma.

For more information about AstraZeneca, please visit:
www.

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Tsuda, Chairman of the Host Organizing
Committee of the Kyoto Conference: "Historically, diagnosis and treatment
recommendations written by specialists without input from primary care were
not always applicable in real life in a busy practice.(4)

Approximately 6.3 million children under 18 years of age have asthma, which
makes it the leading serious chronic illness among children.6 billion healthcare business with more
than 12,000 employees .

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These were the Global Initiative for Asthma (GINA) in 1997, the
Global Initiative for Obstructive Lung Disease (GOLD) and Allergic Rhinitis
and Its Impact on Asthma (ARIA) in 2001.
Wonca will take an active part in the dissemination and implementation of
IPAG through its 100 member organizations , which represent more than 150,000
family doctors around the world.com
Global Initiative for Asthma http://www. Treatment options for childhood asthma can be broken down into
two categories -- controllers and quick-relief (bronchodilators).(4) Asthma is
also the third leading cause of hospitalization among children under the
age of 15 and the number one cause of school absenteeism attributed to a
chronic condition.

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If your child is
switching to Pulmicort Respules from an oral (syrup or pill)
corticosteroid, carefully follow the health care professional's
instructions.

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These guidelines, developed by
panels of leading experts, include the latest evidence available on diagnosis
and treatment and are now the most referenced resources of information on
asthma, COPD and allergic rhinitis, respectively. A special questionnaire module
has been developed to support the differential diagnosis between COPD and
asthma.org
Allergic Rhinitis and its Impact on Asthma http://www. In the year 2000, asthma resulted in 728,000 ED visits and
214,000 hospitalizations in patients under age 18,(2) and ED and
hospitalization rates were highest among children 4 years of age and
younger,(3) despite improvements in currently available asthma medications.

(2 ) Centers for Disease Control 2003, pages 4-6

(3) Centers for Disease Control 2003 Asthma, pages 5, 1, 2

(4) Asthma in Children Fact Sheet, American Lung Association, March 2003

(5) American Academy of Allergy, Asthma & Immunology,
www.

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In addition to supporting IPAG, Wonca will
also be one of the leaders of the Global Alliance against Respiratory Disease
(GARD) - a global initiative spearheaded by the World Health Organization
(WHO). ICS,
which are controller medication with anti-inflammatory properties, may help
prevent asthma exacerbations and control asthma when taken regularly. In the
United States, AstraZeneca is a $9. Earlier use of nebulized inhaled
corticosteroids is associated with fewer exacerbations in young children.

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goldcopd.

The study assessed whether early controller medications, such as the
nebulized ICS Pulmicort Respules (budesonide inhalation suspension),
were associated with improved outcomes for children with asthma.
Poster presented at 61st Annual Meeting of American Academy of Allergy,
Asthma and Immunology.

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org
Global Initiative for Chronic Obstructive Lung Disease http://www.

Parents who recognize the symptoms of asthma in their children -- coughing,
wheezing, chest tightness, and shortness of breath -- should inform their
doctor or healthcare provider and obtain a proper diagnosis of the
condition. Not
all controllers are strictly anti-inflammatory.astrazeneca-us.

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Approximately half of COPD
patients are correctly diagnosed.whiar.globalfamilydoctor. In
this study, exacerbation was defined as one or more ED visits or
hospitalizations during the study period. It is one of the
world's leading pharmaceutical companies with healthcare sales of over
$21. March 19, 2005.org/patients/allergic_conditions/pediatric_asthma

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T.
Notes to Editors:

Additional information:
IPAG Handbook http://www .

About Pulmicort Respules (budesonide inhalation suspension)

Pulmicort Respules uses a nebulizer to deliver the medication to children,
making the delivery more consistent. Pulmicort Respules is not
a quick-relief medicine (bronchodilator) and should NOT be used to treat an
acute asthma attack.(4)

About AstraZeneca

AstraZeneca is a major international healthcare business engaged in the
research, development, manufacture and marketing of prescription
pharmaceuticals and the supply of healthcare services.

asthma allergy

COPD is the leading cause of
smoking-related disability, more than stroke and heart disease.
Global guidelines on the three chronic diseases have been introduced in
recent years. Says Prof.
A new study, presented at the 61st annual
American Academy of Allergy, Asthma and Immunology (AAAAI) showed that
children who were prescribed a nebulized inhaled corticosteroid (ICS) as
first-line treatment for asthma, experienced fewer emergency department
(ED) visits or hospitalizations than children prescribed the medication as
second or third-line treatment .

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"
The expert panel developed and validated a set of questionnaire tools to
help busy primary care physicians attribute the patient's presenting symptoms
to either asthma, COPD or allergic rhinitis . These side effects included respiratory
infection, runny nose, coughing, earache, viral infection , stomachache,
oral thrush and nosebleeds. If your child is exposed to chicken pox or
measles , consult your child's health care professional.(4)

Common symptoms of childhood asthma include coughing either constant or
intermittent; wheezing or a whistling sound audible when your child
exhales; shortness of breath or rapid breathing, which may or may not be
associated with exercise; and chest tightness.4 billion and leading positions in sales of gastrointestinal,
cardiovascular, respiratory , oncology and neuroscience products. AstraZeneca is listed in the Dow Jones
Sustainability Index (Global) as well as the FTSE4Good Index.

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Differential
diagnosis between COPD and asthma is of essential importance as the two
diseases may require different approaches to treatment.

PRESS RELEASE Study Indicated That Early Use of Nebulized Inhaled Corticosteroid Led to Fewer Hospitalizations for Young Children With Asthma

(4) Although asthma can be a life-threatening disease if
not properly managed , the mild to moderate asthma that most children have
can be controlled by treatment at home or in the doctor's office.

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KYOTO, Japan,
- Wonca Announces Release of International Primary Care Airways Group
(IPAG) Report Providing New Approaches to Facilitate the Diagnosis and
Management of Asthma, COPD and Allergic Rhinitis in Primary Care Settings
The first report of International Primary Care Airways Group (IPAG) has
been launched today during the Asia Pacific Regional Conference of the World
Organization of Family Doctors (Wonca).ginasthma.

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Their usability in primary
care , however, has been limited until now, as the guidelines were not
specifically designed for operational use in primary care settings.
The IPAG task force was established in 2002 to develop evidence -based
guidelines specifically designed for use in primary care settings, on the
basis of GINA , GOLD and ARIA.com

(1) Asthma is the most common chronic
medical condition among children under the age of 15 and the third leading
cause of hospitalization in this age group.

For more information on the symptoms and triggers of asthma, as well as
potential treatment options, parents can visit www.

About Childhood Asthma

Asthma has become a serious problem in the United States, especially among
children.

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Management recommendations of IPAG are in conformity with GINA, GOLD
and ARIA. The trial
evaluated a total of 11,407 patients aged 12 months to four years who were
diagnosed with asthma. It is the first and only inhaled
nebulized corticosteroid approved for children with asthma 12 months to 4
years of age.everydaykidz.com.com

(1) Murphy K, Bukstein D, Katz L, et al.

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