The transaction eliminates the following payments that
would have been due to IriSys: milestone payments, royalties in the
mid-single digits payable on sales of Neurodex by AVANIR, and a share
of any future royalties that AVANIR may have received from potential
licensees. To date, AVANIR has not
made any payments to IriSys under the sublicense.

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Going forward , AVANIR will be
obligated to pay The Center for Neurologic Study milestones, a patent
royalty on product sales, and a share of revenues received if AVANIR
sublicenses Neurodex to a third party . The shares of common stock will be registered
for resale, but will be subject to certain resale limitations under
applicable law. AVANIR's
President and Chief Executive Officer Dr. Yakatan will be
presenting a corporate overview at the investor conference at 1:30
p.medcvinc.
Mr.

musculoskeletal loss

S . Food
and Drug Administration (FDA) at the end of 2004 and expects to submit
the final module in mid-year 2005. from August 2002 until St. Paulson joining our Board."

About MedicalCV , Inc.

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AVANIR Acquires Additional Rights to Neurodex Technology

Other than future payment obligations to The Center for
Neurologic Study, AVANIR and its subsidiary did not assume any
liabilities of IriSys. The
Company's first commercialized product, Abreva(R), is marketed in
North America by GlaxoSmithKline Consumer Healthcare and is the
leading over-the-counter product for the treatment of cold sores.com
http://www.

incontinence neurological

AVANIR will have no future
financial obligation to IriSys. AVANIR
has successfully completed two pivotal Phase III trials with Neurodex
for the treatment of pseudobulbar affect, a neurological disorder that
affects approximately one million people in the U.
Mr.495.

Please submit to an appropriate subcategory as no sites are placed in the main category.

cardiovascular ear

"With the positive results of our pivotal Phase III clinical
trials in pseudobulbar affect and Neurodex's potential in the
treatment of diabetic neuropathic pain, the Board believed it
appropriate to retain a greater share of the economics of Neurodex,"
stated James B. In 1997, IriSys
licensed the worldwide rights from The Center for Neurologic Study to
develop and distribute Neurodex.

AVANIR Pharmaceuticals to Present at the White Mountain Capital 3rd Annual Biotechnology Conference

com
The information contained in this press release, including any
forward-looking statements contained herein, should be reviewed in
conjunction with the company's most recent Annual Report on Form 10-K
and other publicly available information regarding the company. Forward-looking
statements often contain such words like "estimate," "anticipate,"
"believe," "plan" or "expect ".
(OTC Bulletin Board: MDCV), http://www. From 2001 to June 2002,
Mr.

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com, a cardiovascular surgery
device manufacturer, announced today that its Board of Directors elected Larry
G.

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Standard + Poor's Corporate Value Consulting group reviewed the
transaction and provided a favorable opinion as to the fairness of the
transaction to AVANIR and its shareholders from a financial point of
view .avanir. The FDA has granted AVANIR's NDA a
Priority Review, which is an accelerated six-month review timeline. Flores, president and chief executive officer of MedicalCV Inc. The Company's core technology
is the ATRILAZE(TM) Surgical Ablation System for use in cardiac tissue
ablation procedures in open-heart surgery.roiny.

MedicalCV, Inc.3000 President / Vice President
jjungbauer@medcvinc.

Features sites that sell products to treat specific conditions and diseases .

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Copies of this information are available from AVANIR upon
request. Our product candidates
address therapeutic markets that include central nervous system and
cardiovascular disorders, inflammation , and infectious disease. Copies
of such information are available from the company upon request.

Paulson is President, Chief Executive Officer and a director of
Restore Medical, Inc. Jude
Medical acquired Endocardial Solutions in March 2005."
For further information on MedicalCV, Inc.com /form.

treat conditions

The submission is being done on a "rolling" basis,
which allows AVANIR to submit the NDA in modules, which can then be
evaluated by the FDA as they are submitted.
The presentation will focus on AVANIR's lead product candidate,
Neurodex(TM), for the treatment of two central nervous system (CNS)
disorders, pseudobulbar affect and diabetic neuropathic pain.
Further information about AVANIR can be found at www. Contact: Investor Relations Contact:
John H.

musculoskeletal immune

Business Editors/Health/Medical Writers
BIOWIRE2K

SAN DIEGO----AVANIR Pharmaceuticals
(AMEX:AVN ) today announced that, through a wholly owned subsidiary, it
has acquired from IriSys, Inc. The sublicense also included an obligation to pay
IriSys a royalty based on annual net sales if AVANIR markets the
product itself and a requirement that IriSys and AVANIR share equally
in any royalties received from a third party. If approved, Neurodex
would be the first drug indicated to treat pseudobulbar affect.
AVANIR Pharmaceuticals is a drug discovery and development company
focused on treatments for chronic diseases. AVANIR began
submission of a "rolling" new drug application (NDA) to the U . Haimovitch is President of Haimovitch Medical Technology Consultants,
a San Francisco-based health care consulting firm he formed in 1990.
Marc P.
Vice President, Finance + CFO Robert Giordano / Sarah Shepard
Phone 651.com

loss ear

additional rights to Neurodex(TM),
AVANIR 's late-stage drug candidate for the treatment of multiple
central nervous system disorders, which was sublicensed from IriSys in
2000. The value of the
transaction will be recorded in the Company 's financial statements as
the sum of the cash paid and the fair market value of the common stock
transferred to IriSys.com

Statements in this press release that are not historical facts,
including statements that are preceded by, followed by, or that
include such words as "estimate ," "anticipate," "believe," "plan" or
"expect" or similar statements, are forward-looking statements that
are subject to certain risks and uncertainties that could cause actual
results to differ materially from the future results expressed or
implied by such statements. Risks and
uncertainties also include the risks set forth in AVANIR's most recent
Annual Report on Form 10-K and subsequent Quarterly Reports on Form
10-Q.medcvinc.452.0200, ext.

sores digestive

"
In August of 2000, AVANIR sublicensed Neurodex from IriSys, a
company co-founded in 1996 by Gerald J.
You may register to receive MedicalCV's future press releases and to be
added to the Company's distribution list by visiting:
http://www.php.

loss ear

nose treat

Further information about AVANIR can be found at www.
AVANIR is also in the process of initiating a pivotal Phase III
clinical trial for Neurodex in the treatment of diabetic neuropathic
pain under a Special Protocol Assessment from the FDA. Final review decisions made by the FDA
and other regulatory agencies concerning clinical trial results are
unpredictable and outside the influence and/or control of the company. as new directors, effective August 3,
2005.

His
firm, whose current area of emphasis includes minimally invasive surgical
technologies, specializes in the analysis of the medical device industry with
emphasis on the current trends and future outlook for emerging medical
technology., a cardiovascular surgery device manufacturer, focuses on
the development and introduction of products designed to improve patient
outcomes through the early treatment of cardiovascular disorders and disease
specifically, products used by cardiac surgeons to ablate cardiac tissue as a
potential means to treat atrial fibrillation.com.com Phone 212.roiny .

respiratory impotence

Glavin, AVANIR's Chairman of the Board. "The terms of
the transaction were negotiated and approved by our Corporate
Governance Committee, comprised solely of independent directors. Food and Drug Administration (FDA)
in December 2004. Beginning in mid-2005, AVANIR
also intends to conduct a Phase III clinical trial for the treatment
of diabetic neuropathic pain under a special protocol assessment from
the FDA. AVANIR disclaims any intent or obligation to update these
forward-looking statements.S. The
Company's first commercialized product, Abreva(R), is marketed in
North America by GlaxoSmithKline Consumer Healthcare and is the
leading over-the-counter product for the treatment of cold sores.

,
commented, "We are extremely pleased to have two individuals with the wealth
of experience in the medical device industry possessed by Mr. Haimovitch and
Mr.

urological halitosis

Yakatan, Ph. Gerald J.

We expect them to play an important role in
shaping our strategy as we continue to develop products for the growing atrial
fibrillation market. The ATRILAZE(TM) system is being utilized for concomitant open-heart
surgical procedures.

immune sores

AVANIR is currently developing Neurodex for the treatment of two
clinical indications, pseudobulbar affect and diabetic neuropathic
pain. In a
market survey commissioned by AVANIR, IMS Health estimated the
potential market for drugs that treat pseudobulbar affect to be
approximately $500 million in 2006, the year in which Neurodex may
enter the market if approved by the FDA. Our product candidates
address therapeutic markets that include central nervous system and
cardiovascular disorders, inflammation, and infectious disease.

Business Editors /Health/Medical Writers
BIOWIRE2K

SAN DIEGO----AVANIR Pharmaceuticals
(AMEX:AVN) will be presenting at the White Mountain Capital
Biotechnology Conference on Tuesday, April 19th in New York .
AVANIR Pharmaceuticals is a drug discovery and development company
focused on treatments for chronic diseases. Paulson was Senior Vice President and General Manager of the Auditory
Division of Advanced Bionics Corporation, and between 1995 and 2001, Mr. 10 / 17
sshepard@roiny.

allergies cold

IriSys was paid $1,925,000 in cash and received 2,000,000 shares
of AVANIR Class A common stock in the transaction . MINNEAPOLIS, MedicalCV, Inc., a company focused on developing and marketing products
for the ear, nose and throat field.

sleep diseases

D. AVANIR had previously disclosed an
obligation to pay IriSys milestone payments related to the clinical
development and regulatory approval of Neurodex in the treatment of
pseudobulbar affect. AVANIR has completed Phase III clinical testing of Neurodex for
the treatment of pseudobulbar affect, and began submission of a new
drug application (NDA) to the U. Eastern time .
The Company disclaims any intent or obligation to update these
forward-looking statements.
MedicalCV, Inc. The Company acquired this
technology in August 2003 and received its FDA 510 (k) clearance in November
2004.

conditions musculoskeletal

As a result, AVANIR, through its subsidiary, holds the exclusive
worldwide marketing rights to Neurodex for five indications under a
royalty-bearing license with the owner of the underlying technology,
The Center for Neurologic Study.S. There can be no assurance that AVANIR will
complete its submission of a new drug application for Neurodex(TM) in
the anticipated time period, that the application, when and if filed,
will be accepted by the FDA, that Neurodex will receive regulatory
approval, or that even if such regulatory approval is received, that
AVANIR will be able to market Neurodex successfully. Robert Paulson, Jr. Paulson served as Chief Financial Officer and Vice President of
Marketing for Endocardial Solutions, Inc. Jungbauer ROI Group Associates, Inc.

throat conditions

MedicalCV Elects Larry Haimovitch and Robert Paulson to Board of Directors

nose neurological

Haimovitch and J.
Paulson served in various capacities at Medtronic, Inc. The Company's common stock is traded on the OTC Bulletin
Board under the symbol "MDCV.

treat nose

Such
publicly available information sets forth many risks and uncertainties
related to the company's business and technology. Prior to joining Restore Medical in April
2005, Mr.

respiratory sleep

, AVANIR's
president and chief executive officer , and Gina Stack.avanir., please visit
http://www.

ear impotence

musculoskeletal loss

sexually immune

AVANIR Acquires Additional Rights to Neurodex Technology

incontinence neurological

Please submit to an appropriate subcategory as no sites are placed in the main category.

cardiovascular ear

AVANIR Pharmaceuticals to Present at the White Mountain Capital 3rd Annual Biotechnology Conference

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respiratory impotence

Features sites that sell products to treat specific conditions and diseases .

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MedicalCV Elects Larry Haimovitch and Robert Paulson to Board of Directors

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