"Previous studies carried out by the Baker Heart Research Institute showed
that arterial stiffness can also be reduced with naturally occurring dietary
isoflavones . "Current U.S.
"The PLAC test is already cleared as a risk factor for coronary heart
disease . Today's additional clearance as a risk factor for stroke is another
important milestone for diaDexus ," said Patrick Plewman, Chief Executive
Officer of diaDexus.com.

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Arterial stiffness, measured across the large arteries in the chest and
abdomen by a non-invasive technique, was significantly improved (reduced) by
the course of trans NV-04 treatment. (Nasdaq: MSHL; London: MSH).
You should be aware that our actual results could differ materially from those
contained in the forward-looking statements, which are based on management's
current expectations and are subject to a number of risks and uncertainties,
including, but not limited to, our failure to successfully commercialize our
product candidates; costs and delays in the development and/or FDA approval,
or the failure to obtain such approval, of our product candidates;
uncertainties in clinical trial results; our inability to maintain or enter
into, and the risks resulting from our dependence upon, collaboration or
contractual arrangements necessary for the development, manufacture,
commercialization, marketing, sales and distribution of any products;
competitive factors; our inability to protect our patents or proprietary
rights and obtain necessary rights to third party patents and intellectual
property to operate our business; our inability to operate our business
without infringing the patents and proprietary rights of others; general
economic conditions; the failure of any products to gain market acceptance;
our inability to obtain any additional required financing; technological
changes; government regulation; changes in industry practice; and one-time
events. These inhibitors represent a new
generation of therapeutics in development to potentially reduce cardiovascular
disease and death.plactest.

preventative pak

The
PLAC test will help physicians more accurately predict who is at risk for
future stroke, so that the individual and his or her physician can take
proactive and preventative measures, such as lifestyle modification or
therapeutic intervention, including statins and daily aspirin.

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"
This study was supported by the National Institutes of Health (NIH) along
with funding from GlaxoSmithKline .

periodically diabetics

The study tested a metabolite of isoflavones, trans NV-04. This explains the success
demonstrated by a number of Novogen's synthetic isoflavonoid compounds in a
range of indication areas," said Professor Alan Husband, Research Director for
Novogen. The Company is developing a range of therapeutics across
the fields of oncology, cardiovascular disease and inflammatory diseases and
phenoxodiol, its lead anti-cancer agent is currently in advanced Phase II
clinical trialling.

lymphedema coronary

This study shows that metabolites formed in the body from
ingested isoflavones are highly active. While elevated cholesterol levels
are highly predictive of heart disease, no such relationship has been
established for stroke .

lumpectomy cardiovascular

Statements included in this press release that are not historical in
nature are "forward -looking statements" within the meaning of the "safe
harbor" provisions of the Private Securities Litigation Reform Act of 1995.
The PLAC test measures an enzyme in the blood called lipoprotein-associated
phospholipase A2 (Lp-PLA2). These findings are independent of traditional risk factors
such as systolic blood pressure, smoking status and diabetes, as well as body
mass index.

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STAMFORD, Conn .
Under U. We do not intend to update any of these factors or to publicly
announce the results of any revisions to these forward-looking statements.

preventative natures

The trial was double-blind, so that neither subjects nor investigators
knew the order in which the test isoflavone or a placebo were taken in a
cross-over design in which the drug or placebo was tested over consecutive
periods each of 5 weeks. guidelines for
screening and prevention of cardiovascular disease are based on the risk for
development of coronary heart disease and do not include risk for stroke.com.

lymphedema natures

, A Phase Ib clinical
trial testing the Novogen cardiovascular investigational drug trans NV-04 has
been completed at the Baker Heart Research Institute in Melbourne, Australia.
"In addition, the test drug was very well absorbed and had an excellent
safety profile. After the results of these trials are
submitted in a new drug application to the FDA, the FDA must approve the drug
as safe and effective before marketing can take place.

diaDexus Receives FDA Clearance to Market the PLAC(TM) Test for Assessing Risk of Stroke

Results from the National Heart Lung and Blood Institute's Atherosclerosis
Risk in Communities (ARIC) study demonstrated that individuals with elevated
levels of Lp-PLA2 have a statistically significant twofold risk of suffering
an ischemic stroke over a period of 6-8 years compared to individuals with low
levels of Lp-PLA2., director of the Center for
Cardiovascular Disease Prevention at Baylor College of Medicine and the
Methodist DeBakey Heart Center in Houston .

About the PLAC Test
The PLAC test was originally cleared by the FDA as an aid in predicting an
individual's risk for coronary heart disease in July 2003. The PLAC test is currently available
through laboratories nationwide, including Quest Diagnostics Incorporated
(NYSE: DGX ), Mayo Medical Laboratories, ARUP Laboratories and Berkeley
HeartLab.

jovi fibrosis

marshalledwardsinc.
"Unlike cholesterol levels, which did not significantly vary between cases
and noncases, Lp-PLA2 was a significant and independent predictor of stroke in
the ARIC study," said Christie Ballantyne, M .

analyzer fibrosis

Worsening of arterial stiffness, or compliance, is linked with increased
risk of future heart attacks; therefore it is expected that trials of drugs
that lower arterial stiffness will demonstrate a concomitant lowering of heart
attack risk."
Recent research has shown that statin therapy significantly reduces
Lp-PLA2 levels. It is now cleared
to aid in the prediction of an individual 's risk for a coronary event, and
ischemic stroke associated with atherosclerosis, in conjunction with clinical
evaluation and patient risk assessment. More information about the company may be
found at http://www.

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diaDexus.

fibrosis analyzer

Blood pressures, both systolic and
diastolic, were also lowered significantly. Nestel said.com. Food and Drug Administration (FDA) has granted the
Company marketing clearance for the PLAC test, making it the first blood test
to aid in predicting risk for ischemic stroke associated with atherosclerosis.

jovi venous

Novogen Investigational Drug Improves Cardiovascular Risk in Human Trials

The trial results show significant improvement in blood pressure and arterial
stiffness in patients at risk of cardiovascular events such as heart attack
and stroke, but with no drug related side effects. With several risk factors for
heart disease, stiffness of arteries is often present and increases the
likelihood of blood pressure rising. Indeed, evidence for improved effects on arterial compliance is
now required by many regulatory bodies for registration of new drugs where
cardiovascular therapeutic claims are sought.D.

coronary jovi

"
"It is well known that arteries become stiff as people become older or
overweight, or as their blood pressure rises.

Each year approximately 700,000 strokes
occur, 88% of which are ischemic strokes.

cardiovascular lymphedema

More information on the Novogen Group can be found at
http://www. today
announced that the U. Because Lp-PLA2 and systolic blood pressure levels are additive in
their ability to predict stroke risk, the PLAC test can help identify
stroke-prone hypertensive patients. In addition, GlaxoSmithKline is developing Lp-PLA2 inhibitors
as a potential anti-atherosclerosis therapy.

nutrients periodically

This
metabolite, an isoflavonoid compound synthesized by Novogen, was administered
orally to 25 middle-aged men and women who were overweight and also suffered
from at least two complications of fatness: abnormal blood fats, high blood
glucose or raised blood pressure.

venous analyzer

For more information about the PLAC test, visit http://www.

About diaDexus
diaDexus, a privately held biotechnology company based in South San
Francisco, California , is focused on the discovery, development and
commercialization of novel, patent-protected diagnostic and therapeutic
products with high clinical value.

insufficiency diabetics

Stroke is the third largest killer in the United States and a leading
cause of serious long-term disability.

assesses cholesterol

"The PLAC test provides new information , over and above
traditional risk factors, that can guide physicians and patients to make the
necessary changes that may prevent patients from suffering cardiovascular
disease and events, like stroke and heart attack.

swelling assesses

S. law, a new drug cannot be marketed until it has been
investigated in clinical trials .

pak assesses

"The present study confirms that isoflavonoid compounds exert clinically
beneficial effects on the functioning of large arteries," said Professor Paul
Nestel, Principal Investigator in the study and also a Director of Novogen., diaDexus, Inc.

insufficiency syrup

Novogen (Nasdaq: NVGN) is an Australian biopharmaceutical company
specializing in the development of therapeutics based on the isoflavonoid
chemical structure. The Novogen group of companies includes the listed
subsidiary Marshall Edwards Inc.

mastectomy cholesterol

The results of this study are
encouraging in producing a range of cardiovascular benefits without side
effects, indicating a potential for this to be used to avoid heart disease in
large numbers of healthy or at risk patients," Prof. PLAC Test Is First Blood Test Approved to Predict Risk for Ischemic Stroke
Associated With Atherosclerosis

SOUTH SAN FRANCISCO, Calif .S.