We believe lubiprostone could provide an important new treatment
option for the millions of people who suffer from chronic constipation and its
difficult symptoms," said Sachiko Kuno, Ph. Further, results from the RW study indicated no rebound
effect after treatment discontinuation.
Based in Lincolnshire, Il.

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, a
leader in functional fatty acid research and development, today announced that
it has submitted a new drug application (NDA ) to the United States Food and
Drug Administration (FDA) on March 31, 2005 to market lubiprostone , a novel
compound with a unique mechanism of action, for the treatment of chronic
idiopathic constipation (CIC) and associated symptoms in adults.
For the NDA application, Sucampo provided results from two Phase III
pivotal efficacy studies, results of a randomized withdrawal (RW) study and
three long-term safety studies, including two 12-month safety studies. Patients diagnosed with IBS are commonly
classified as having constipation-predominant IBS, diarrhea-predominant IBS or
alternating IBS (alternating between constipation and diarrhea).S.com for more information.

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These
pivotal studies demonstrated that lubiprostone produced rapid and sustained
effects in treating the symptoms of constipation , performing significantly
better than placebo in men and women over age 18 for all constipation
variables tested.com.

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Administered orally, the agent has been shown to work locally in the GI
tract by activating specific chloride channels (a protein that carries
chloride) on cells lining the small intestine, increasing intestinal fluid
secretion.D. Through
the Takeda Global Research + Development Center, Inc.N.

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, Sucampo Pharmaceuticals, Inc., president and chief executive
officer of Sucampo . Sucampo and Takeda reached an
agreement in October 2004 that provided Takeda marketing rights for the U. Chronic constipation is a disorder of colonic motility that is
present for at least three months and results in infrequent bowel movements
and demonstrated difficulty in evacuating stools . The company, founded in 1996 by Dr. BEAR CREEK, Wis. "With modest improvements in diet and physical
activity, we can dramatically improve our overall health.

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S.S.

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Sucampo Submits New Drug Application for Lubiprostone an Investigational Compound for the Treatment of Chronic Idiopathic Constipation

Lubiprostone also is being evaluated for other GI indications.
Sucampo Pharmaceuticals, Inc . is
a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, the
largest pharmaceutical company in Japan. Glucosinolates in sauerkraut activate
the body's antioxidant enzymes, and flavonoids protect artery walls from
oxidative damage. "But the truth is, Americans should be eating
fermented foods like sauerkraut all year and in a variety of other dishes from
salads to pizza," Reed says ., C.

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subsidiary will market lubiprostone in the U.
Ryuji Ueno and Dr.

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com.

In addition to playing a role in cancer prevention, Reed states there is
strong evidence that low-calorie, high -fiber sauerkraut may also promote
cardiovascular and digestive health.

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"
Once the FDA grants approval, Takeda Pharmaceutical Company's U. To learn more about Sucampo,
visit http://www.sucampo .

-- Men who eat three or more servings of cruciferous vegetables per week
are shown to have a 41 percent decreased risk for prostate cancer
compared to those who eat less than one serving.

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Sucampo's functional fatty acid platform is based on the
discoveries of Company Founder, Dr., the company has a
robust pipeline with compounds in development for diabetes , sleep,
cardiovascular disease and other conditions.

Nutritionist Says USDA's MyPyramid System Doesn 't Go Far Enough Challenges Consumers to Eat Specific Vegetables to Reduce Cancer Risk

" Reed offers this supporting information:

-- Cruciferous vegetables contain phytochemicals with antioxidant
properties that experts say may reduce the risk of cancer.
-- A University of Illinois study found sauerkraut to block the action of
estrogen, in vitro, a finding that could mean sauerkraut may help to
lower the risk of breast cancer and reproductive-tract malignancies in
women.
-- Sauerkraut is high in lactic acid, which cleanses the digestive tract
of harmful bacteria, enhancing immune function and helping to prevent
colon cancer ., C.

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"This NDA submission marks a significant product milestone in Sucampo's
history.
In addition to the NDA indication, Sucampo has completed a Phase II trial
that studied lubiprostone for constipation-predominant irritable bowel
syndrome (IBS-C).krrrrispkraut.

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5 million visits to physicians and 92,000
hospitalizations annually.D.

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Factors contributing to the development of
constipation include not enough fiber in the diet, lack of exercise, irritable
bowel syndrome, neurological and systemic disorders and problems with the
colon and rectum or intestinal function. Other contributing factors include
side effects from medication, particularly pain medications, antidepressants,
antacids , antispasmodics and blood pressure medications.

About Irritable Bowel Syndrome (IBS)
IBS is a chronic, recurrent disorder characterized by the multiple
symptoms of abdominal pain and discomfort, bloating, and extreme changes of
bowel habits such as constipation and/or diarrhea . There are currently few choices of treatment available for the
multiple symptoms of IBS. Sachiko Kuno in Bethesda, MD, focuses principally on
developing novel therapies for gastrointestinal, liver and circulatory
indications, and is strategically selecting and developing candidates for
other indications.

About Takeda Pharmaceuticals North America, Inc. To learn more about the company and its
products, visit http://www.
-- Research has shown cancer rates drop as much as 40 percent when
consumers go from low to high consumption of cruciferous vegetables.N.

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About Dana Reed, M.

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It affects between two to
27 percent of the population in Western countries . According to the American Gastroenterological
Association, the cause of IBS is not known, although lifestyle factors or
psychological stress may play a role. The condition
causes a great deal of discomfort and distress for its sufferers.

About Sucampo Pharmaceuticals, Inc.com for meal ideas and sauerkraut recipes.S.

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and Canada for the agent in the gastroenterology indications , as well as the
option for marketing rights in other territories, including Japan and Europe.
"We are pleased with this NDA submission by our partner Sucampo, as it
surely will support the realization of our ongoing commitment to providing new
and innovative options to physicians and their patients," said Yasuchika
Hasegawa, president and chief operating officer at Takeda. It is reported that
approximately 30 million people in North America meet the diagnostic criteria
for IBS. Takeda is committed to striving
toward better health for individuals and progress in medicine by developing
superior pharmaceutical products.
Nutritionist and Great Lakes Kraut consultant Dana Reed says eating up to
six servings of vegetables per day, including three to four servings per week
of cruciferous vegetables, like cabbage, cauliflower, or broccoli, may play a
role in reducing the risk for certain types of cancer.
"We know that 30 percent of cancers in developed countries can be traced
to diet," says Reed, "which means simple dietary changes can reduce a person's
risk by up to 30 percent.

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R-Tech Ueno, Ltd (Tokyo, Japan), a member of Sucampo Group, will manufacture
and supply the drug. In the United States, it
results in more than 2. In the United States, Takeda
currently markets oral diabetes and cholesterol-lowering treatments.

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This increased fluid level softens the stool , promotes spontaneous
bowel movements, and reduces abdominal discomfort, pain and bloating. is a pharmaceutical company that
concentrates on developing compounds from its proprietary functional fatty
acid technology platform, which consists of exclusive rights in the Americas
to a portfolio of more than 650 patents." Visit
http://www.

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S., Although the MyPyramid food
guidance system highlights the importance of eating vegetables, one
nutritionist is advising Americans to go beyond the vegetable serving
recommendations, and to regularly include cruciferous vegetables and fermented
foods in their diet. What's more, a study
published in the October 2002 issue of the Journal of Agriculture and Food
Chemistry shows that fermenting cabbage into sauerkraut may increase its
ability to prevent cancer growth in the breast, colon, lung, and liver.
Sauerkraut is often considered a seasonal food eaten on hot dogs or with
pork during the holidays. Log on to
http: //www.

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"Our studies suggest that lubiprostone's unique mechanism
of action may offer a more targeted approach to managing the symptoms of
constipation.

About Constipation and Chronic Constipation
Constipation, defined as infrequent and difficult passage of stool, is one
of the most common disorders suffered by Americans. Other contributing
factors include side effects from medication , particularly narcotic
analgesics, antidepressants, anticholinergics, antispasmodics and
antihistamines ., Takeda Pharmaceuticals North America, Inc.

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BETHESDA, Md. IBS is considered to be one
of the most common gastrointestinal disorders. While not
life threatening, it can significantly interfere with daily activities and
reduce their quality of life. Ryuji Ueno.tpna.

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The company expects the agent to enter Phase III trials
soon.krrrrispkraut.
With expertise as a nutritionist, dietitian , and personal trainer, Dana
Reed currently operates a successful therapeutics practice in New York City.

About Great Lakes Kraut
Great Lakes Kraut manufactures and markets the leading brands of
sauerkraut, Silver Floss and Krrrrisp Kraut.