infesting archaeologists

is working to provide safe and effective
medicines to the world .
Barry J.

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With this
funding, Perlegen will use high density oligonucleotide array
technology to discover a comprehensive genome-wide set of single
nucleotide polymorphisms (SNPs) in Yersinia species which will aid in
distinguishing strains and understanding their biology.
Plans are also being made to develop a structure to use data from the
longitudinal health study started 40 years ago in the regional community of
Busselton in the south-west of Western Australia for genomic research.

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"We are very excited about contributing to NIAID's efforts in
biodefense," stated Renee Stokowski, Ph.D.

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"Some of our other leading biotech companies and researchers are attending
BIO in Chicago.

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"We hope our work leads to the development of a cost-effective
and rapid diagnostic tool for distinguishing Yersinia pestis strains. This information is used to explain and
predict the efficacy and adverse effect profiles of prescription
drugs. Marshall

PERTH, Australia, 2005 Nobel Prize winner
Professor Barry Marshall will be part of Western Australia's biggest
contingent of 22 life sciences companies visiting Chicago for the annual
Biotechnology Industry Organization (BIO ) conference this month (April).

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Business Editors/Health/Medical Writers
BIOWIRE2K

MOUNTAIN VIEW, Calif.
Historically, as many as 200 million people have died from bubonic
plague.

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The BIO conference, from 9-12 April, will be Professor Marshall's first
visit to the US since winning the Nobel Prize.

Biological studies of human remains taken from archaeological sites.

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Perlegen Sciences , Perlegen, and the
Perlegen logo are trademarks of Perlegen Sciences, Inc.
"We are immensely proud of Professor Marshall and Dr.

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"Western Australia will continue to invest in our very talented
researchers and use the achievements of Professor Marshall and Dr.

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Based in Mountain View, California, Perlegen was formed in late
2000 as a spin-off from Affymetrix, Inc. 22 Biotechnology Companies from Western Australia to Join Prof. Warren," Premier
Carpenter said .

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, Associate Director of
Association Studies at Perlegen and Principal Investigator of this
study . "In
addition to creating a SNP resource that can be used for diagnostic
purposes, we expect to gain insights into the relationship between
Yersinia pestis and Yersinia pseudotuberculosis, and the biology of
these two species," stated Dr. Perlegen also applies this expertise to discovering genetic
variants associated with disease for potential new therapeutics and
diagnostics. He will join Premier Carpenter
in showcasing the State of Western Australia and its achievements in life
sciences.

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archaeologists pylori

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announced today that it has received a biodefense
partnership grant award from the National Institute of Allergy and
Infectious Diseases (NIAID) to analyze the genomes of approximately
150 Yersinia pestis and Yersinia pseudotuberculosis strains."
Informative SNPs identified by Perlegen will be made publicly
available to researchers through dbSNP and other websites.

2005 Nobel Prize Winner Professor Barry Marshall to Participate in BIO 2006

Fiona Wood was made Australian of the Year for her work on
tissue regeneration for burns victims, and Professor Harvey Millar won
Australian Life Scientist of the Year for his research into plant energy
biology, which will create plants with higher yields, environmental tolerance
and greater biomass for future fuel production. Media Contact:
MacDougall Biomedical Communications
Peter Steinerman (516) 374-3031
Kari Watson (508) 647-0209

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"There is considerable life-enhancing research under way in Western
Australia, and it has enormous potential to contribute to future discoveries
in the fields of human health, animal health and industrial biotechnology,"
Professor Marshall said.

U .S.

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com.
Western Australia's Premier, Alan Carpenter, is leading the delegation of
46 industry representatives, from companies and research centers in Western
Australia, to the conference.

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He is well-known for proving that the bacteria
Helicobacter pylori is the cause of stomach ulcers, reversing decades of
medical doctrine which held that ulcers were caused by stress, spicy foods,
and too much acid.
"Last year Dr.

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Yersinia pestis is the causative agent of the plague. In the event of an outbreak, a genome-wide set of
SNPs and the patterns of variation that allow differentiation between
individual strains could be valuable in identifying the source of the
pathogen. Gary Andersen , Staff Scientist at
Lawrence Berkeley National Laboratory, who will collaborate with
Perlegen on this study. The company quickly and cost effectively
analyzes millions of genetic variations in DNA samples obtained from
clinical trial participants.perlegen.
Premier Carpenter has made Western Australia's life sciences sector a
priority for the State by focusing on creating collaborative research
environments between universities, hospitals and healthcare foundations and
encouraging a culture of commercialization.
The Premier recently announced the establishment of a new medical research
centre, the Centre for Food and Genomic Medicine, which will focus on
world-leading research into obesity and diabetes.

tummy skeleton

Perlegen Sciences to Analyze Plague-Causing Bacteria with Biodefense Grant from National Institute of Allergy and Infectious Diseases

Warren to
inspire them along the way ," he said.

prehistory misleading

For years, scientists and drug manufacturers have been
eager to comprehensively examine entire genomes; through Perlegen,
this is now possible. Perlegen is able to bring drugs to the market
wherein clinical development could have been otherwise discontinued. Professor Marshall received the 2005 Nobel Prize in
Medicine with fellow Western Australian scientist Dr.

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Cases of plague are rare today, but the potential use of
Yersinia pestis as a biological weapon in acts of terrorism or war is
a serious concern."
Premier Carpenter said Western Australian industry and research was
growing at a tremendous pace and there was a strong commitment from his
Government to build upon the achievements.

paleoanthropology prehistory

Yersinia pseudotuberculosis is a genetically similar species
that can also cause infections in humans.

About Perlegen Sciences

Perlegen Sciences, Inc. Marshall, MBBS (born in Kalgoorlie, Western Australia) is an
Australian physician and Professor of Clinical Microbiology at the University
of Western Australia. Robin Warren for their
ground-breaking research into Helicobacter pylori and stomach ulcers.

infesting totaling

----Perlegen
Sciences, Inc. (Nasdaq:AFFX). For more
information about the company and its technologies, visit Perlegen's
website at www. "They are among a growing number of Western Australians making
outstanding achievements in their field.

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