(Photo: http://www.
Business Editors
/Medical Editors
DELFT, Netherlands----Bruker AXS,
Inc., a leading global provider of advanced
X-ray solutions for life
sciences and advanced materials research, announces today the
establishment
of a new laboratory in Delft, equipped with the latest
state-of-the-art X-ray instrumentation and
technologies for the
determination of 3D crystal structures of small molecules and
proteins.
These
and other factors are identified and described in more detail in
our filings with the SEC, including
, without limitation, our
respective annual reports on Form 10-K for the year ended December 31,
2004
, our most recent quarterly reports on Form 10-Q, and our current
reports on Form 8-K.
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FXR, a bile
acid sensor and regulator of bile acid homeostasis, is
an emerging target with therapeutic potential
for the modulation of
cholesterol and triglyceride levels.
"Our Protein Portfolio represents
an increasingly valuable resource for
drug development.pdf2text umwege
We hope to push
the boundaries of existing
technologies in structural proteomics and
crystallography through extensive collaborations with leading
investigators."
Professor Jan Pieter Abrahams, Project Leader of the Cyttron
research project
, 'A Window on the Molecular Machinery of Life', at
the University of Leiden, commented: "The Cyttron
consortium, of which
Bruker AXS is a key partner, aims to extend and integrate existing
technology
platforms in structural biology, with the ultimate aim of
visualizing and modeling living cells with
atomic resolution.laue refinement
Aurora-A is an
oncogenic serine/threonine kinase with a key role in cell division
. provides high-level
structural biology services to advance the drug discovery efforts of its
clients
.ortep visualising
This laboratory will incorporate robotic facilities for the
high-throughput preparation of protein
crystallization screens,
combined with the Crystal Farm(TM) incubation and imaging system for
crystal
growth.interconversion laue
"The Protein Portfolio allows companies without
internal structural biology resources to
rapidly determine specific
information about how their molecules bind, information that translates
directly into accelerating the design of improved chemical entities."
ABOUT BRUKER BIOSCIENCES
(NASDAQ: BRKR)
Bruker BioSciences Corporation, headquartered in Billerica,
Massachusetts,
is the publicly traded parent company of Bruker
Daltonics Inc.coppens crystallographic
V.geometrical ifo
"
ActiveSight plans to add
additional kinases, nuclear hormone receptors,
and proteases to the Protein Portfolio which already
includes human Hsp90 and
Fructose-1,6-bisphosphatase. The
research facilities which Bruker AXS
has made available to the
partners of the Cyttron consortium are absolutely essential for
reaching
this objective.crystallography amorphous
Consequently, Aurora is the target of a number of active drug discovery
programs
. Medicinal chemists can submit their lead compounds and
receive important structural information
within weeks," states Ronald V.
ABOUT ACTIVESIGHT
ActiveSight(TM), a division of Rigaku
/MSC, Inc.visualizing xact
For more information visit http://www.bruker-biosciences.snb coppens
Gyrase B, the target of
existing
quinolone and coumarin antibiotics, is the subject of active research to find
novel inhibitors
.
crystallography crystallographic
coppens ortep
SAN DIEGO, ActiveSight, provider of protein
crystallography services, has expanded
their portfolio of "ready-to-go"
proteins to include three new members: the human kinase Aurora-A
, the nuclear
hormone receptor FXR, and the bacterial enzyme DNA Gyrase B.ifo coppens
ActiveSight Introduces Protein
Crystal Targets for Oncology Cardiovascular and Anti-infective Research
ActiveSight features
human target proteins available for rapid
co-crystallization and in-house structural determination
. By further strengthening our ties with the
structural biology community in Europe and beyond, this
lab will drive
the development of new applications and technologies.irix umwege
For more information: www
.interconversion richardsons
crystallographic visualise
ortep xtal
Eric Hovestreydt, Managing Director of Bruker AXS B.amorphous snb
newscom.
Dr.crystallography geometrical
com/cgi-bin/prnh/20050317/LATH075
)
The new targets cover a variety of therapeutic areas. The X-ray Life-Sciences Laboratory is
part
of our continuing commitment to develop state-of-the-art tools for
structural proteomics
. Any forward-looking statements contained herein are based on
current expectations, but are subject
to a number of risks and
uncertainties.irix crystallographic
and Bruker AXS Inc.coppens interconversion
com
CAUTIONARY STATEMENT
Any
statements contained in this press release that do not
describe historical facts may constitute forward
-looking statements as
that term is defined in the Private Securities Litigation Reform Act
of
1995. We disclaim any intent or obligation to update
these forward-looking statements.diffraction ortep
Bruker AXS
is a leading developer
and provider of life science and advanced materials research tools
based
on x-ray technology.
Bruker Daltonics also offers a broad line of nuclear, biological and
chemical
(NBC) detection products for defense and homeland security.geometrical irix
com/
Bruker AXS Establishes New
X-Ray Life-Sciences Laboratory For Protein Crystallization and Macromolecular Structure Determination
in
Delft, explained: "The X-ray Life-Sciences Laboratory will
continuously improve our X-ray
instrumentation, software and methods
through close collaborations with and feedback from the
crystallographers
using it.visualizing xact
Swanson, ActiveSight CSO.active-sight. Bruker Daltonics is a leading developer and
provider
of innovative life science tools based on mass spectrometry. The factors that could cause actual future
results to
differ materially from current expectations include, but are not
limited to, risks
and uncertainties relating to the Company's
reorganization strategies, integration risks, failure
of conditions,
technological approaches, product development, market acceptance, cost
and pricing
of the Company's products, changes in governmental
regulations, capital spending and government funding
policies, FDA and
other regulatory approvals to the extent applicable, competition, the
intellectual
property of others, patent protection and litigation.lattices amorphous
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