Business Editors/Health/Medical Writers/High -Tech Editors
BIOWIRE2K

MENLO PARK, Calif. Longer term,
these tools may prove useful in validating novel therapeutic targets
and predicting the side effects of experimental therapies.gov /ntv

For information about the Vision for Space Exploration on the Internet,
visit:

http://www.

base representation

nasa.

relates anything

"This feature is one means by which
Pathway Logic offers the potential for researchers to model complex
cellular networks in a familiar or intuitive way. Ultimately, we
intend to make our integrated and interactive online Pathway Logic
tools available to a wide community of biologists and biomedical
researchers.sri.

foundations automated

csl.gov/home

relates knowledge

cgi?acqid=117555

Deadline for submissions is October 18, 2005.

programming action

With IOP as the
infrastructure, SRI researchers will begin to integrate a user
interface, a model repository, new visualization tools, and various
biological databases into Pathway Logic. The support of NIGMS is helping to make this possible.

reasoning foundations

In the project's first phase, SRI demonstrated a novel
computational approach to help researchers create , analyze, and test
models of complex EGFR signaling networks. SRI developed some of these tools
as part of a Web-based Pathway Logic viewer that allows multiple
queries of graphical models of EGFR biochemistry.nasa.

representation researchers

For information about NASA TV's digital channels on the Internet, visit:

http://www.

ideas anything

"Pathway Logic models of biological systems are unique in that
they are executable -- the models exist only when assembled on demand
from user-defined starting states," said Keith Laderoute, director of
SRI's Cancer Biology Program.

answer representation

In the second phase of the project, SRI will increase the utility
and predictive capabilities of Pathway Logic by enhancing the ability
of researchers to interact with the models.gov/cgi-bin/eps/synopsis.

actions representation

This could
dramatically speed drug development and improve the safety of new
drugs -- major issues for pharmaceutical and biotechnology companies
today. In addition to conducting contract R+D, SRI
licenses its technologies, forms strategic partnerships and creates
spin-off companies. WASHINGTON , NASA is seeking proposals from
organizations interested in an unfunded collaboration with the agency to
create, produce and program broadcast-quality television video products for
NASA Television 's public information channel.

relates ideas

NASA Seeks Broadcast Partner For Digital Television Channel

anything formal

The NIGMS grant provides support for the mathematical modeling of
complex mammalian signaling and other biological networks, using SRI's
unique formal methods tools.
A formal Request for Entrepreneurial Opportunity (REO) that includes a
statement of purpose, scope, requirements and evaluation criteria is available
on the Internet at:

http://prod.

logic answer

The
nonprofit research institute performs client-sponsored research and
development for government agencies, commercial businesses and
nonprofit foundations.

effects planning

com/), to model
biological entities and processes.

effects anything

The approach uses SRI's
patent -pending Pathway Logic(TM) pathway analysis software, based on
the Maude computer language (http: //maude.com) is one of the
world's leading independent research and technology development
organizations .

actions programming

----SRI
International, an independent, nonprofit research and development
institute, today announced continuation of an important grant from the
National Institute of General Medical Sciences (NIGMS , a unit of the
National Institutes of Health) to model complex mammalian signaling
networks based on signaling of the epidermal growth factor receptor
(EGFR).

Anything that relates to logic-based knowledge representation systems, knowledge base systems, systems for planning and action.

actions under

sri.

logic reasoning

relates researchers

This phase will include
development of the Pathway Logic Assistant, an application of the
InterOperability Platform (IOP), a separately funded research project
to enable the formal methods tools written in the Maude language to
communicate and interact with each other.

semantics ideas

Products may make use
of the NASA archives or live special events conducted by, or of special
interest to, the agency.

actions answer

The ultimate research goal of Pathway Logic is to create models of
large-scale signaling networks in defined cell types -- computational
models of mammalian cells defined in terms of their molecular
responses to specific environmental signals.

under relates

SRI International Begins Second Phase of National Institute of General Medical Sciences Grant for Mathematical Modeling of Biological Systems; Formal Method To

Founded as Stanford Research Institute in 1946, SRI has
been meeting the strategic needs of clients for almost 60 years.

logic anything

"

About SRI International

Silicon Valley-based SRI International (www.
Programming would focus on NASA-related topics, such as aeronautics,
space, science and technology .nasa.

formal anything

Promoting the mathematical modeling of
biological systems is a primary goal of NIGMS, which intends to
disseminate such tools to biologists to help them understand the new
paradigm of systems biology and to design experiments. Products may include material previously
produced by the organization , or newly created products.nais.