The software enables both analysis and web
publishing of model-organism databases that integrate genome and
pathway information to harness the overwhelming amount of information
produced by large-scale genome sequencing efforts . They are a versatile
family, ranging in properties from rigid to highly elastic, and can be
converted into molded and thermoformed goods, extruded coatings and film,
blown film, fibers, adhesives, and many other products.

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humancyc.org
The HumanCyc database is the seventeenth in SRI's growing
collection of BioCyc (http://biocyc.com) is one of the
world's leading independent research and technology development
organizations. Founded as Stanford Research Institute in 1946, SRI has
been meeting the strategic needs of clients for almost 60 years. These versatile materials are produced from renewable resources
such as corn sugar, and combine the functionality of traditional plastics with
biodegradability in a wide range of environments, including soil, marine, and
wetlands. Peoples, one of the company 's founders and its chief
scientific officer.

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For
more information, visit us at http://www.

Metabolix 's Natural Plastics Win Presidential Green Chemistry Challenge Award

Today's ceremony, to be held in Washington, DC, will recognize the
company in the small business category.
(Photo: http: //www.
Metabolix was selected as a winner by an independent panel of technical
experts who reviewed a highly competitive group of nominations for this
recognition. Metabolix has also received
government support for its technology from the US Department of Energy's
Biomass Program, the Biomass Research and Development program at the US
Department of Agriculture, and the US Department of Commerce's Advanced
Technology Program.

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, Ingenuity
announced today that Pfizer Inc.com/cgi -bin/prnh/20050620/NEM025 )
"This award recognizes Metabolix' success in transforming PHA Natural
Plastics technology from a biological curiosity to a commercial reality,"
notes Oliver P.D.

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The researchers were able to identify 35
pathways shared among the three organisms: human, bacteria and plant.com.newscom. They can be both hot and cold composted.epa.

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This pathway framework also allowed SRI to identify
203 probable missing enzymes in the human genome, and SRI's newly
developed pathway hole filling algorithm generated high-scoring
candidate genes for 25 of those enzymes. The company
was founded in 1998 and is headquartered in Mountain View, California., Metabolix, Inc.

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Ingenuity delivers systems biology expertise to biologists and
bioinformaticians through pathways analysis software, genome-scale computable
network databases, and knowledge management services and infrastructure ,
resulting in increased productivity and faster drugs to market. They have excellent
shelf life and resistance even to hot liquids, greases, and oils, yet they
biodegrade in aquatic, marine and soil environments and under anaerobic
conditions such as found in septic systems and municipal waste treatment
plants.
More information on the Presidential Green Chemistry Awards is available
at: http://www.

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SRI's Pathway software tools combine representation and inference
techniques from artificial intelligence with extensive scientific
visualization capabilities.

About SRI 's Bioinformatics Research Group

SRI International's Bioinformatics Research Group is a leader in
the development of database content and software tools for the
bioinformatics field.

Contact information:
James Barber
President and CEO
617-492-0505, x225
barber@metabolix.

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In addition to conducting contract R+D, SRI
licenses its technologies, forms strategic partnerships and creates
spin-off companies."

Founded in 1992, Metabolix, Inc .

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ingenuity.

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Using SRI's PathoLogic(TM)
software, the analysis assigned 622 human enzymes to roles in 135
predicted metabolic pathways. Scientists can use BioCyc
databases to visualize the layout of genes within a chromosome, a
complete biochemical pathway, and the full metabolic map of an
organism .

Founder and Chief Scientific Officer
617-492-0505, x212,
peoples@metabolix .

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Ingenuity Announces Expansion of Pfizer Relationship

The latest release of the Ingenuity
Pathways Analysis application provides a novel approach for scientists to
compare and understand biological states, a critical capability for decreasing
attrition and speeding time to market in pharmaceutical research and
development.

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For this work, SRI researchers partnered with researchers at
Stanford University and Indiana University-Purdue University of
Indianapolis.
In November 2004, the company announced an alliance with Archer Daniels
Midland to commercialize its fermentation technology , and in March 2005
announced an alliance with British Petroleum to further develop direct
production of Natural Plastics in switchgrass.

researchers holothuroidea

"The human genome is incomprehensibly vast and complex; Pathways
provide a framework for organizing the human genome so that scientists
can more easily understand and manipulate it according to molecular
interactions," said Peter Karp, Ph.

About SRI International

Silicon Valley-based SRI International (www.

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Business Editors/Health/Medical Writers
BIOWIRE2K

MENLO PARK, Calif. "SRI's goal is to provide biologists
with the 'power tools' they need to understand and analyze the genome
in a much more useful way. By structuring information into pathways ,
we provide a unique genomic framework to more easily group and analyze
our biochemical machinery ."
One of SRI's software tools, the HumanCyc Omics Viewer, allows
researchers to visualize combinations of gene expression, proteomics,
and metabolomics data by painting them onto the cellular overview of
human metabolism.

About HumanCyc

HumanCyc is part of SRI's BioCyc Database Collection , a group of
pathway and genome databases that includes EcoCyc, MetaCyc, and
databases for 163 other species; the MetaCyc metabolic pathway
database contains data from 350 species. The
nonprofit research institute performs client-sponsored research and
development for government agencies, commercial businesses and
nonprofit foundations. (NYSE: PFE) has expanded its licensing of the
Ingenuity Pathways Analysis software.

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To date, SRI has licensed Pathway software tools
to more than 400 academic and commercial organizations.gov/greenchemistry.

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org/) pathway and genome
databases.com

Oliver Peoples, Ph.

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The pathways and the analysis results
are available in the HumanCyc database at www.
As part of this work, SRI researchers compared the metabolic
pathways of humans and two other well-understood organisms,
Escherichia coli (the bacteria better known as E.com/.

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, director of SRI's
Bioinformatics Research Group.sri. is the world leader in applying the
advanced tools of metabolic engineering and molecular biology to produce
Natural Plastics from renewable resources in microbial systems and directly in
non-food plant crops.

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SRI International Demonstrates Computational Method for Mapping and Predicting Human Metabolic Pathways and Proteins

----

HumanCyc Bioinformatics Database Increases Genomic Collaboration

SRI International, an independent nonprofit research and
development organization, has performed a computational analysis of
the human genome to predict metabolic pathways and to predict new gene
functions within the human genome.

abnormality researchers

"

About Ingenuity Systems
Ingenuity Systems is helping life science researchers understand
biological systems that are foundational to human health and disease.
Metabolix Natural Plastics are today made through fermentation of
renewable resources such as corn sugar and vegetable oil, and, in the future ,
will be produced directly in plants such as switchgrass.

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coli) and
Arabidopsis thaliana, a small flowering plant widely used as a model
organism in plant biology. An article about the group's collective findings,
"Computational prediction of human metabolic pathways from the
complete human genome ," was published in the December 22, 2004 issue
of Genome Biology.
"Pfizer has embraced pathways analysis software in their research and
development activities," stated Jake Leschly, President and CEO of Ingenuity. For more information, visit http://www.

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For example, one pathway in the HumanCyc
database describes genes that work together to break down nicotine;
another pathway contains the group of genes that make cholesterol.
"Ingenuity is pleased to provide expanded access of Ingenuity Pathways
Analysis to more Pfizer researchers.

The Presidential-rank awards are given to select individuals and
organizations that have made dramatic science contributions with identifiable
applications that result in less pollution and/or waste in a manufacturing
process.

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D. Pfizer Expands Licensing of Ingenuity Pathways Analysis Software

MOUNTAIN VIEW, Calif. CAMBRIDGE , Mass.metabolix.

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HumanCyc provides a genome-based view of human nutrition
that could foster a better understanding of the links between genome,
diet and health. has won the 2005
Presidential Green Chemistry Challenge Award for its progress in
commercializing a broad family of Natural Plastics that will provide
significant environmental benefits compared with current petrochemical
plastics .com