Through its educational
programs at Harvard Medical School and other academic institutions, the Center
has created the infrastructure to educate the medical profession on
personalized medicine approaches."
Salmon genotyping involves obtaining a small piece of salmon fin
for use as a DNA sample. SNP genotyping provides a more
rapid method for generating DNA data. Selected markers will be used in
the development of a standardized database for use among Pacific
coastal nations, including the United States, Russia, Japan, and
Korea.

state.

hmm sockeye

D.
For more information on the Developing Cooperative Databases for
Pacific Salmon SNP Workshop , visit
http://www. These factors include but are not limited
to (1) rapidly changing technology and dependence on the development
of new products; (2) sales dependent on customers' capital spending
policies and government-sponsored research; and (3) other factors that
might be described from time to time in Applera Corporation's filings
with the Securities and Exchange Commission. All information in this
press release is as of the date of the release, and Applera does not
undertake any duty to update this information, including any
forward-looking statements, unless required by law. and F.

emboss sequence

High-density GeneChip microarrays interrogate hundreds of
thousands of SNP markers per individual for less than one cent per genotype. In addition to supporting HPCGG research, the new
Affymetrix technology will further strengthen the HPCGG core facilities
supporting the broader research community with genomic and other high
throughput services. K.7 billion during fiscal 2004. Celera Diagnostics , a 50/50 joint
venture between Applied Biosystems and Celera Genomics, is focused on
discovery , development, and commercialization of diagnostic products.

nucleotide similarity

, and Bedford, Mass. Affymetrix expressly disclaims any obligation or
undertaking to release publicly any updates or revisions to any
forward -looking statements contained herein to reflect any change in
Affymetrix' expectations with regard thereto or any change in events,
conditions, or circumstances on which any such statements are based .

Alaska Department of Fish and Game Expands Project for Salmon Conservation and Population Management Using Applied Biosystems Technology

"The application of SNP genotyping is an exciting advance for
salmon conservation and will enable us to better monitor the health of
wild salmon populations ," said Jim Seeb, Ph.
"Wild-life agencies across the world are beginning to see the
importance and effectiveness of applying advanced genetic analysis
techniques in their conservation efforts ," said William V. Customers use these tools to
analyze nucleic acids (DNA and RNA), small molecules , and proteins to
make scientific discoveries, develop new pharmaceuticals, and conduct
standardized testing. The
Celera Genomics Group (NYSE:CRA) is engaged principally in the
discovery and development of targeted therapeutics for cancer,
autoimmune and inflammatory diseases.

For Research Use Only.

emboss hmm

The Women's Health Study is under the overall
direction of Dr. Affymetrix
is headquartered in Santa Clara, Calif.
Such statements are subject to risks and uncertainties that could cause actual
results to differ materially for Affymetrix from those projected, including,
but not limited to risks of the Company's ability to achieve and sustain
higher levels of revenue, higher gross margins , reduced operating expenses,
uncertainties relating to technological approaches, manufacturing, product
development (including uncertainties relating to the use of the 500K array and
outcome of the research project with HPCGG discussed in this press release),
personnel retention, uncertainties related to cost and pricing of Affymetrix
products, dependence on collaborative partners, uncertainties relating to sole
source suppliers, uncertainties relating to FDA and other regulatory
approvals , competition, risks relating to intellectual property of others and
the uncertainties of patent protection and litigation.

About Biomax

Biomax Informatics AG (Martinsried, Germany), a leader in the
development of customized bioinformatics solutions, was founded in
1997 as a spin-off of the GSF-MIPS academic research group, now the
German Research Center for Environment and Health-Institute for
Bioinformatics (GSF-IBI).
Additional information about Biomax can be found at the company 's site
on the World Wide Web at www."
Research published in several journals this month, including
Transactions of the American Fisheries Society and Molecular Ecology,
highlights Applied Biosystems TaqMan assays in detailing the biology
of salmon and improving management of commercially important salmon
and shellfish species.

phred sequence

D., Director of the Center for Cardiovascular
Disease Prevention at BWH.
The early access arrangement with Affymetrix exemplifies HPCGG's
flexibility in adopting new technologies with the rigorous quality controls of
a production facility.

Biomax Informatics AG and Softberry Inc. Extend Collaboration

Founded by Dr. Mewes, Biomax developed the well-known
Pedant-Pro(TM) Sequence Analysis Suite, the HarvESTer(TM) EST Assembly
and Clustering System, and other bioinformatics tools used in
metabolic pathway, proteomics, and gene expression analyses . Additional information is
available at www.com, or by telephoning
800-762-6923.

phred distributable

Software Writers/Health Editors
BIOWIRE2K

MARTINSRIED, Germany and MOUNT KISCO, N.softberry.
The decline of some wild salmon populations in the Pacific Ocean
is a threat to regional economies and an indicator of potential
problems in the global ecosystem. Not for use in diagnostic procedures .

phred repeats

The Center is among a handful of early access sites that
will start applying these new Affymetrix arrays to study real-world disease. These and other risk
factors are discussed in Affymetrix' Form 10-K for the year ended December 31,
2003 and other SEC reports, including its Quarterly Reports on Form 10-Q for
subsequent quarterly periods. W.adfg.ak.appliedbiosystems.

This category is for sites about stand-alone computer programs which process biological information such as genetic sequences.

emboss similarity

(Nasdaq: AFFX) announced an
agreement that will provide HPCGG with early access to next-generation
Affymetrix GeneChip(R) Human Mapping microarrays capable of scanning up to
500,000 single nucleotide polymorphisms (SNPs), or variations of DNA sequence
in the human genome. Since then,
Affymetrix GeneChip(R) technology has become the industry standard in
molecular biology research.----

To Provide an Integrated Bioinformatics Environment That Combines
Data Management and Retrieval of Biological Information with the Most
Comprehensive Array of Sequence and Structure Analysis Programs

Biomax Informatics AG and Softberry, Inc. D.

oligonucleotide sockeye

About Affymetrix
Affymetrix scientists invented the world's first high-density microarray
in 1989 and began selling the first commercial microarray in 1994. H. Its functional site prediction programs, TSSW/TSSG/TSSP,
NSITE and PromH, and genome mapping and comparison programs, Prot_Map,
FMAP, EST_MAP, GenomesMatch and others, are widely acclaimed as
fastest the most accurate.

genetics.

The PCR process and the 5' nuclease process are covered by patents
owned by Roche Molecular Systems, Inc.
Applied Biosystems and Celera are registered trademarks and Applera
and Celera are trademarks of Applera Corporation or its subsidiaries
in the U.

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The Affymetrix technology will allow HPCGG researchers to
investigate at an unprecedented scale the genetic origins of atherosclerosis,
a condition where the arteries become clogged. Julie Buring, also of BWH. The Center also operates full-service
genetic clinics for patients with known or suspected genetic conditions, and
core facilities and services for genetic study design, DNA sequencing,
genotyping, proteomics, bioinformatics and microarrays. The Applied
Biosystems Group serves the life science industry and research
community by developing and marketing instrument-based systems,
consumables, software, and services.

sockeye mauve

Co-investigators in this
project include Paul Ridker, M. As one part of conservation efforts,
researchers are using advanced DNA analysis technologies to track
salmon migration patterns, intermixing of populations, and identify
risk factors for these commercially and environmentally important fish
species.

rearranged distributable

, Ph.
"The Affymetrix microarray system will be a key component of the Harvard
Medical School -- Partners HealthCare lab bench-to-bedside continuum, which
integrates genetics and genomics data into clinical decision support . Frishman, Dr.com

About Softberry sequence and structure analysis software

Softberry FGENESH family of gene prediction and genome annotation
programs is being used for annotating vast majority of newly sequenced
genomes.

Business Editors/Health/Medical Writers/Science Editors
BIOWIRE2K

ANCHORAGE, Alaska + FOSTER CITY, Calif.
As a part of this initiative, Applied Biosystems, the Genetics
Section of the American Fisheries Society, and the Alaska Department
of Fish and Game are hosting the Developing Cooperative Databases for
Pacific Salmon SNP Workshop April 28-29 , 2005 to discuss the
development of cooperative databases for Pacific Salmon, and to foster
multi -national standardization among member nations bordering the
Pacific Ocean.
Information about Applera Corporation, including reports and other
information filed by the company with the Securities and Exchange
Commission, is available at http://www. These forward-looking statements are
based on Applera Corporation's current expectations.

Copyright(C) 2005.

cdna structual

, with manufacturing facilities in
Sacramento, Calif.

biomax., (Mount Kisco, NY, USA) is a leading developer of
software tools for genomic and proteomic research.
"Applied Biosystems TaqMan(R) SNP Genotyping Assays are a robust, easy
to use, and high performing technology that should help researchers at
the Alaska Fish and Game and elsewhere conserve economically-important
species, such as salmon. These products help eliminate the
labor, expense, and bioinformatics expertise previously necessary for
generating high quality SNP genotyping data.

sockeye computes

, Today, the Harvard Medical School - Partners HealthCare Center for Genetics
and Genomics (HPCGG) and Affymetrix, Inc. We believe that Affymetrix GeneChip
technology , including our new upcoming Mapping 500K arrays, will help
researchers at HPCGG and elsewhere to make discoveries that directly benefit
patients," said Greg Yap, Vice President, DNA Products, Affymetrix .

About the Harvard/Partners Center for Genetics and Genomics
HPCGG is a joint enterprise between Harvard Medical School and Partners
HealthCare System, dedicated to accelerating the realization of personalized
medicine by discovering and integrating genetic knowledge into the healthcare
system . Affymetrix technology is used by the world's top
pharmaceutical, diagnostic and biotechnology companies as well as leading
academic, government and not-for-profit research institutes. More than 1,000
systems have been installed around the world and nearly 3,000 peer-reviewed
papers have been published using the technology.----

Applied Biosystems, American Fisheries Society, and Alaska
Department of Fish and Game to Host Salmon Genotyping Workshop

The Alaska Department of Fish and Game and Applied Biosystems
Group (NYSE:ABI), an Applera Corporation business, a leading provider
of DNA analysis technologies, today announced at the Developing
Cooperative Databases for Pacific Salmon SNP Workshop in Anchorage,
Alaska the expansion of a multi-national genotyping project using
Applied Biosystems TaqMan(R) SNP Genotyping Assays for the
conservation and management of wild salmon populations in the Pacific
Ocean., Co-Director of the
Gene Conservation Laboratory, Alaska Department of Fish and Game.

plasmid sockeye

Reynolds Center for Cardiovascular Research at Brigham and Women's Hospital
(BWH).
Affymetrix arrays enable scientists to search the human genome and
identify genes contributing to complex diseases, such as atherosclerosis,
cancer and asthma.
"From world-class research , to access to a major physician network serving
over 2 million patients, HPCGG has the resources needed to start translating
genomic results into better health care. The Center combines world-class scientific talent with access to a
population of over 2 million patients and their physicians, providing a
continuum of resources and expertise to rapidly translate scientific
discoveries into treatments that benefit the patient. Applied Biosystems is headquartered in Foster
City, CA, and reported sales of $1. Hoffmann-La Roche Ltd.

sockeye biochip

D.

NOTE: Affymetrix, the Affymetrix logo, and GeneChip are registered
trademarks owned or used by Affymetrix, Inc., announce the
integration of a wide array of genome analysis programs from Softberry
into the Biomax Pedant-Pro(TM) Sequence Analysis Suite and BioRS(TM)
Integration and Retrieval System, creating a powerful and flexible
environment for management, access and analysis of biological data.com

About Softberry

Softberry, Inc . Information about Applied Biosystems is available at
www. All rights reserved.

biochip oligonucleotide

, Director of Genotyping for HPCGG.
Discoveries of gene-disease associations can be rapidly translated into
clinical diagnostic tests by our team of researchers and clinicians, bringing
benefits to the patient in months rather than years," said Raju Kucherlapati,
Ph.D. Using Applied Biosystems 3730 DNA Analyzers,
TaqMan (R) SNP Genotyping Assays, and Applied Biosystems Real-Time PCR
Systems, the Alaska Department of Fish and Game will first sequence
and then genotype the salmon DNA to identify and select single
nucleotide polymorphisms (SNPs) to use as genetic identification
markers for salmon population studies.php

About TaqMan(R) SNP Genotyping Assays

Applied Biosystems offers more than two million TaqMan(R) SNP
Genotyping Assays to provide more robust coverage of the genome for
gene -finding and human disease association studies, and offers
researchers Custom TaqMan(R) SNP Genotyping Assays for additional
human SNPs and insertion-deletions, as well as support for
polymorphisms in other species.
TaqMan is a registered trademark of Roche Molecular Systems, Inc.

taqman gde

Use of
the microarrays in the HPCGG core technology facilities will make this and
other large scale gene-disease association studies possible," said David
Kwiatkowski, M. The Reynolds Foundation is funding this study.Y. Dr.us/snpworkshop. The Private
Securities Litigation Reform Act of 1995 provides a "safe harbor" for
such forward-looking statements. Applera Corporation.

sequence hybridisation

More than 1,200 patient samples
will be examined and will come from the Women's Health Study, an ongoing
10-year National Institutes of Health (NIH) funded study of cardiovascular
events in 38,000 women., Scientific Director of the HPCGG.

All statements in this press release that are not historical are
"forward-looking statements" within the meaning of Section 21E of the
Securities Exchange Act as amended, including statements regarding Affymetrix'
"expectations," "beliefs," "hopes," "intentions," "strategies" or the like. Softberry customers include over 50
leading pharmaceutical, biotech and agribusiness companies , as well as
academic research institutions worldwide. "As
we track migration and interception points, it is important that we
gain a better idea of the potential impact of climate change, hatchery
production, and fishing to promote sustainable fishing practices, and
assist regulators in enforcing international treaties. It is also seeking to advance therapeutic antibody and
selected small molecule drug programs in collaboration with global
technology and market leaders.

annotation similarity

"Using the Affymetrix microarrays, we can scan a whole genome for genetic
variation in just 24 to 48 hours. Kwiatkowski is also a principal investigator within the Donald W. The company maintains important sales
and marketing operations in Europe and Asia and has about 900 employees
worldwide. Heumann
and Prof.S. and/or certain other countries.

ncbi sequence

, and SANTA CLARA, Calif. Prior to this technology, it would have
been inconceivable to genotype hundreds of patient samples. Together with a
large panel of serum markers from the Women 's Health Study, this will bring us
a lot closer to understanding the genetic contribution to inflammation and
cardiovascular disease, and predicting who may or may not be at risk.
The substantial cost savings compared with currently available methods is
making this atherosclerosis study, as well as other large-scale studies,
cost-effective for the first time. Kucherlapati added that such
tests form the foundation of personalized medicine approaches that HPCGG is
seeking to advance -- the ability to select the best treatment for the
individual patient based on his or her genetic profile.
The research is expected to begin when the 500K arrays become available
under a limited release Early Access program in the first half of 2005. Other widely used programs include protein
sub-cellular localization prediction program ProtComp and an array of
protein modeling tools. Murray,
President of the Molecular Biology Division for Applied Biosystems.cf.

About Applera Corporation and Applied Biosystems

Applera Corporation consists of two operating groups. Celera Genomics is leveraging
its proteomic, bioinformatic, and genomic capabilities to identify and
validate drug targets, and to discover and develop small molecule
therapeutics. In order to comply with the terms of
the safe harbor, Applera Corporation notes that a variety of factors
could cause actual results and experience to differ materially from
the anticipated results or other expectations expressed in such
forward -looking statements.

rearranged gde

Harvard Medical School - Partners HealthCare Center for Genetics and Genomics to Launch Major Genotyping Study in Atherosclerosis with Affymetrix Technology

CAMBRIDGE, Mass.

Dr. Dr.

hybridisation mdh

Affymetrix' patented
photolithographic manufacturing process provides the most information capacity
available today on an array, enabling researchers to use a whole-genome
approach to analyze the relationship between genetics and health.
The system provides a comprehensive database and software package that
can accommodate user-specific preferences to include approximately a
hundred software modules addressing specific research needs related to
sequence analysis, protein modeling and visualization. Its list of
commercial products includes a family of gene, promoter and functional
site prediction, new genome annotation, genomes comparison and
sequence mapping programs , RNA and protein structure modeling tools,
protein sub-cellular location and epitope prediction, database of
regulatory motifs and many others.com

Applied Biosystems Forward Looking Statements

Certain statements in this press release are forward-looking.

plasmid emboss

D. The assays are part of
the Applied Biosystems genotyping solution, which also includes
Applied Biosystems Real-Time PCR Systems .applera.
These may be identified by the use of forward-looking words or phrases
such as "should " among others.