D.D.
"Dr .D."
Dr. ( http://www.

proteins expression

University of Oxford Completes External Validation of SEQUENOM's MassARRAY (R) Gene Expression Application

com/cgi-bin/prnh/20040415/SQNMLOGO)
The MassARRAY QGE procedure is known as real competitive polymerase chain
reaction (rcPCR) and consists of competitive PCR in conjunction with MALDI-TOF
mass spectrometry to determine nucleic acid levels within a sample., SEQUENOM 's Chief Scientific Officer.; Sue Kinnamon, Ph.; and Stephen Roper, Ph.

genomics molecular

Most commonly used technologies are 2-D gel electrophoresis for protein
separation and analysis of proteins by mass spectrometry . Protein
chips are also proving to be useful. More than 300 companies have been identified to be
involved in proteomics and 211 of these are profiled in the report with 437
collaborations.

For more information visit
http://www. The system is
able to deliver reliable and specific data from complex biological samples and
from genetic target material that is only available in trace amounts.

Dr.

Biochemistry, Molecular Biology, Molecular Genetics and Proteomics.

biochemistry molecular

Toxicoproteomics , i. The article, entitled
"Development and evaluation of real competitive PCR for high-throughput
quantitative applications," demonstrates the ability to measure nucleic acid
abundance, a process that allows scientists to gain a better understanding of
the expression level of genes and how various disease states, treatments and
cell stimuli change those levels. Nilius is a leading international expert in the biology of cell
signaling through ion channels, and he brings a wealth of knowledge ,
experience and contacts to our research initiatives," said Ray Salemme, Ph.; The Society of General Physiologists (USA) and the
American Physiological Society.D.

gene cytobiology

For
more information, please visit http://www. These forward-looking statements are based on current information
that is likely to change and speak only as of the date hereof. Linguagen's bitter blockers and flavor enhancers reduce
the need for excess sugar and salt and contribute to the development of
healthier, better-tasting foods, beverages and pharmaceuticals.

proteomics evolution

com/reports/c14198 ) has announced the addition
of Proteomics - Technologies, Markets and Companies to their offering. He received his M.

evolution clinical

Analysis of different levels of gene expression in healthy and
diseased tissues by proteomic approaches is as important as the detection of
mutations and polymorphisms at the genomic level and may be of more value in
designing a rational therapy. (Nasdaq: SQNM) announced today."

About SEQUENOM
SEQUENOM is committed to providing the best genetic analysis products that
translate genomic science into superior solutions for molecular medicine and
biomedical research. Biology and Biochemistry Expert to Help Further Taste Technology Research

CRANBURY, N. Nilius is a Full Professor of Physiology in the Department of
Physiology, Gasthuisberg Campus, Leuven, Belgium. in Mathematics
and Physiology from Martin Luther University, Halle-Wittenberg, in
Halle/Saale, Germany.com ) is a biotechnology firm that
identifies and develops compounds to improve the taste of pharmaceutical, food
and beverage products.

proteomics evolution

newscom.

SEQUENOM(R) and MassARRAY(R) are registered trademarks of SEQUENOM, Inc .

botany proteomics

Research and Markets: Proteomic Technology Markets to Treble from $6 Billion in 2005 to $18 Billion by 2015

researchandmarkets. Microanalytical
protein characterization with multidimentional liquid chromatography/mass
spectrometry improves the throughput and reliability of peptide mapping. Use of bioinformatics is essential for analyzing the
massive amount of data generated from both genomics and proteomics.
Collectively, the value of markets for proteomic technologies in the year
2005 is about $6 billion and is expected to increase to $10 billion by the
year 2010 and $18 billion by the year 2015.J., Linguagen Corp.linguagen.com ), a leader in the identification and development
of new compounds to improve the taste of pharmaceutical, food and beverage
products, announces the addition of Bernd Nilius, M.

signal apoptosis

Proteomics will play an
important role in medicine of the future which will be personalized and will
combine diagnostics with therapeutics., 2005) have
successfully tested the MassARRAY system to demonstrate the accuracy,
sensitivity and reproducibility of the system," said Jiannis Ragoussis, Ph.K.

botany metabolism

Matrix-Assisted Laser Desorption Mass Spectrometry (MALDI-MS) has become a
widely used method for determination of biomolecules including peptides,
proteins.
Proteomics is providing a better understanding of pathomechanisms of human
diseases.com
Fax: +353 1 4100 980

D.

clinical molecular

researchandmarkets.

biochemistry genomics

(Logo: http://www.

clinical enzymes

e. Furthermore, they discovered that MassARRAY QGE provides
greater sensitivity and needs less individual assay optimization, compared to
RT-PCR. "This factor, combined
with the ability to quantitatively analyze submicroscopic chromosomal
deletions and amplifications, makes MassARRAY QGE a powerful tool for cancer
research.

ecology apoptosis

the evaluation of protein expression for
understanding of toxic events, is an important application of proteomics in
preclincial drug safety. In
addition, the researchers at Oxford University developed a statistical
analysis tool (TITAN) designed for competitive PCR applications., to its
scientific advisory board (SAB). He is an editorial board
member of several international journals, including The Journal of Physiology
(London), The American Journal of Physiology, Cell Calcium, The Journal of
Physiology and Cellular Physiology and Biochemistry, and will be the Editor in
Chief of The European Journal of Physiology Pflugers Archive commencing in
November 2005.

chemistry biochemistry

Functional proteomics technologies include yeast two-hybrid system
for studying protein- protein interactions. Establishing a proteomics platform
in the industrial setting initially requires implementation of a series of
robotic systems to allow a high-throughput approach for analysis and
identification of differences observed on 2-D electrophoresis gels. Protein distribution / characterization in body
tissues and fluids, in health as well as in disease, is the basis of the use
of proteomic technologies for molecular diagnostics. SAN DIEGO , Researchers at the Wellcome
Trust Centre for Human Genetics at the University of Oxford successfully
completed testing of the MassARRAY(R) Quantitative Gene Expression (QGE)
application, SEQUENOM , Inc. They also determined that SEQUENOM's MassARRAY QGE method has the
added potential of detecting submicroscopic deletions within chromosomal DNA.
"Scientists at University of Oxford (Elvidge et al. "In addition, the methods for measuring relative gene
expression differences were demonstrated in a relatively high throughput
manner."
"The MassARRAY system delivers superior sensitivity and reproducibility
which makes it ideal for Quantitative Gene Expression analysis," said Charles
Cantor, Ph.com.D.D.

About Linguagen
Linguagen Corp.

physiology molecular

Linguagen Adds Bernd Nilius to Scientific Advisory Board

,
CEO of Linguagen Corp. and Ph.linguagen.

botany genetics

DUBLIN, Ireland, Research and Markets
(http://www. The Company's proprietary MassARRAY system is a
high-performance DNA analysis platform that efficiently and precisely measures
the amount of genetic target material and variations therein. Prior to this position, he
was the Leader of the Max Planck Research Group for Molecular Cell Physiology
connected to the Max Planck Institute of Biophysical Chemistry in Gottingen ,
Germany.

expression genomics

The findings were
reported today in the journal Analytical Biochemistry.
The study demonstrated that MassARRAY QGE delivers data with a high level
of concordance to Real Time PCR (RT-PCR), the current "gold standard" for gene
expression analysis. Continued development of rcPCR has the potential to establish the
use of MassARRAY technology in the established and growing gene expression
market.sequenom. "His skills complement those of the other outstanding
members of our board, and we're confident that together they will provide
Linguagen with key guidance as we continue to discover new compounds that
improve the taste of medicines, foods and beverages. He is a member of several international scientific societies,
Academia Europea; the Royal Academy of Medical Sciences Belgium; The
Physiological Society U.D.

evolution clinical

com/cgi-bin/prnh/20040820/RESEARCH )
This report describes and evaluates the proteomic technologies that will
play an important role in drug discovery, molecular diagnostics and practice
of medicine in the post-genomic era -- the first decade of the 21st century.
The number of companies involved in proteomics has increased remarkably
during the past few years.com/reports/c14198

Laura Wood
Senior Manager
Research and Markets
press@researchandmarkets.

Except for the historical information contained herein, the matters set
forth in this press release, including statements regarding rcPCR's potential
to establish the use of MassARRAY technology in the established and growing
gene expression market, are forward-looking statements within the meaning of
the "safe harbor" provisions of the Private Securities Litigation Reform Act
of 1995.
( http://www.

metabolism cell

D,
Head of the Genomics Group at the Wellcome Trust Centre for Human Genetics,
University of Oxford.

chemistry ecology

Proteomic technologies are now being
integrated into the drug discovery process as complimentary to genomic
approaches.newscom.D.

genetics botany

These forward-looking statements are subject to risks and
uncertainties that may cause actual results to differ materially, including
the risks and uncertainties associated with the development and
commercialization of any new technology, and particularly risks and
uncertainties related to technology acceptance by the gene expression market,
and other risks detailed from time to time in SEQUENOM's SEC filings,
including SEQUENOM's Annual Report on Form 10-K for the year ended December
31, 2004., Ph. Nilius joins four prominent scientists
and industry leaders in the field of taste transduction and technology who
also serve on the board, including Robert Margolskee, M ., Ph.

cytobiology expression

The markets for proteomic technologies are difficult to
estimate as they are not distinct but overlap with those of genomics, gene
expression, high throughput screening, drug discovery and molecular
diagnostics.D.; David
Floyd, Ph.

analytical botany

The largest expansion will be in
bioinformatics and protein biochip technologies.
(Logo: http://www.D. He has had 318 papers published in peer reviewed international
journals and has been invited to lecture at more than 90 international
meetings , including the International Society of Biophysics and Applied
Physics; European Society of Human Genetics; American Heart Association; and
American Physiological Society, Gordon Conferences.

biomolecules chemistry

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