(4)
Pertussis also has a financial impact on the family.
Adolescent pertussis immunization programs were recently implemented
countrywide. Pertussis Disease Information. Accessed April 8,
2005. 2004;15:351.S.

cholera thrombosis

She has spent her
career collecting and tracking world-wide travel health information.

U.S. FDA Licenses sanofi pasteur's ADACEL(TM) Vaccine for Combined Protection Against Tetanus Diphtheria and Pertussis

CDC for administration in a five-
dose series between the ages of 2 months and 6 years. MMWR
2004;54 (3):67-71.

redbook traveler

S. Pertussis immunity from early childhood vaccinations wears off,
leaving adults and adolescents susceptible to the disease, which they can then
transmit to others.
These risks and uncertainties include those discussed or identified in the
public filings with the SEC and the AMF made by sanofi-aventis, including
those listed under "Risk Factors" and "Cautionary Statement Regarding Forward-
Looking Statements" in sanofi-aventis' annual report on Form 20-F for the year
ended December 31, 2004.

(6) Lee GM, et al.

(8) O'Keefe, C.

thrombosis malaria

visitors, people need to learn more
about the country before embarking there," says Ms.
Passport Health, a chain of more than 100 offices nationwide, is a travel
health and immunization center, which provides customized travel health
counseling.(5) Another study,
published in 2004, found that the majority of adults missed an average of 9. If the decision is made
to administer ADACEL vaccine in such persons, it should be given with caution,
with steps taken to avoid the risk of hematoma formation following injection.2 cases per 10,000 in 2004.4 million per day. Outbreaks of Pertussis
Associated with Hospitals - - Kentucky, Pennsylvania,
and Oregon, 2003.cdc.

(5) Lee HL , Pichichero ME. Costs of Illness Due to Bordetella pertussis in
Families. Societal Costs and Morbidity of Pertussis in
Adolescents and Adults. Media Relations
Tel.Lavenda@sanofipasteur.

dvt fevers

Increased U.S. Travel to China Requires Vigilant Health Counseling

S. Increase in deaths from
pertussis from young infants in the United States in the 1990s, Pediar Infect
Dis J.

CONTACT:
Len Lavenda
sanofi pasteur U.

sickness biannual

8
days of work due to their disease, while adolescents missed an average of 5. In these studies, ADACEL vaccine
stimulated robust antibody responses nearly identical to those from Td vaccine
for protection against tetanus and diphtheria, and exceeding those following
three doses of the analogous diphtheria-tetanus-acellular pertussis given to
infants for protection from pertussis. Before then, only whole cell pertussis vaccine was available
which carried an increased risk of adverse events in individuals over 7 years
of age.

[Note: Prescribing information and Fact Sheets about ADACEL vaccine and
pertussis are available upon request]

(1 ) Centers for Disease Control and Prevention.

glaxosmithkline redbook

ADACEL vaccine is the first
booster to address pertussis -- or whooping cough -- protection across a wide
range of ages (11 through 64 years), and the first and only such booster
licensed for adults in the U. At particular risk are newborns who have not yet been
fully vaccinated against pertussis(1), are more vulnerable to severe
pertussis, and face the possibility of serious complications and even death. CDC's Advisory Committee on Immunization Practices (ACIP) will
meet in upcoming months to update recommendations for the prevention and
control of pertussis, including vaccination of adults and adolescents. Available at:
http://www.

biannual sickness

military, Post Office and Federal employees, as well as providing
smallpox training. It is a licensed product in Canada and
Germany. FDA reviewed the results of four principle clinical studies that
included more than 7,200 individuals. The studies concluded that the safety
profile of ADACEL vaccine was very similar to that of Td vaccine when
administered to adults and adolescents.
In clinical studies, the adverse events associated with ADACEL vaccine
were very similar to those from the current Td vaccine and consisted primarily
of transient pain, swelling or redness at the injection site, and low-grade
fever of short duration. The most common systemic adverse events include
headache , body ache, and tiredness. Other than as required by applicable law, sanofi-
aventis does not undertake any obligation to update or revise any forward-
looking information or statements.
Manuscript in preparation.: 570-839-4446
Len.

biannual vaccinations

for Protection against Pertussis
from Adolescence through Adulthood

SWIFTWATER, Pa.S.

Growing Threat
Preliminary data from the U. Following the introduction of ADACEL vaccine,
pertussis incidence in the Northwest Territories decreased from 7.
The company offers the broadest range of vaccines , providing protection
against 20 bacterial and viral diseases. Forward-looking statements are generally identified by the words
"expect," "anticipates," "believes," "intends," "estimates," "plans" and
similar expressions.

(2) Vitek CR, Pascual FR, Baugham, AL, Murphy TV.gov/incidod/dbmd /diseaseinfo/pertussis_t. 2000;9:989-996.

dvt traveldoctor

citizens in 2004, with 1.S. Lessans.
"Pertussis, or whooping cough, is a family disease. occurring among adolescents and adults has increased considerably , to
nearly two-thirds in 2003.

(4) Centers for Disease Control and Prevention.com

Craig Heit
Cooney/Waters Group
Tel.: 212-886-2200
cheit@cooneywaters .

thrombosis diarrhea

Not only do travelers to China need a flu
shot, she adds "they need careful protection from food and waterborne
illnesses, as well as mosquito-borne diseases, such as malaria, depending on
their specific destination and whether it's rainy season."
North and South China's two very different climates pose different
challenges.9 cases per
10,000 in the late 1990s to just 0. Abstract in Can J Infect Dis Med Microbiol.

restrooms sickness

Lessans, whose goal is to prevent travel
illness. Her company subscribes to multiple list servers and websites with
international, up-to-date health and safety information .(7) In
Newfoundland, no person vaccinated with ADACEL vaccine has been diagnosed with
the disease to date. Backed by a world-class R+D
organization, sanofi-aventis is developing leading positions in seven major
therapeutic areas: cardiovascular disease, thrombosis, oncology, metabolic
diseases , central nervous system, internal medicine, and vaccines.

traveler traveldoctor

Passport Health specializes in itinerary-specific
education, travel health products and international security counseling.
Passport Health has been involved in providing anthrax vaccinations to the
U. FDA to recommend the vaccine's
licensure . CDC indicate that there were nearly 19,000
case reports of pertussis in 2004, a 63 percent increase over 2003 and the
highest number of case reports in four decades.S.

ADACEL Vaccine - Development
The development of a pertussis booster vaccine for use from adolescence
through adulthood was not possible before the advent of acellular vaccines in
the mid-1990s.
ADACEL vaccine was licensed in Canada in May 1999 for use in persons 11 to
54 years of age, and in Germany in July 2001 as COVAXiS(TM) (TdcP Vaccine;
Tetanus and Diphtheria Toxoids Adsorbed Combined with Component Pertussis
Vaccine) for use in persons 10 years and older.sanofipasteur.com. 2003:22:628:634.htm.

biannual outbreaks

Centers for Disease Control and Prevention
(CDC) reported that in cases where the source of the disease was identifiable,
adults were responsible for over half of pertussis cases in infants, with
parents the source for 47 percent and grandparents for 8 percent of cases. Adults and
adolescents are at risk of contracting and transmitting the infection because
the protection from childhood immunization appears to diminish over time,"
said Russell Steele, MD, professor and vice chairman of the Department of
Pediatrics at Louisiana State University School of Medicine in New Orleans.S. The
sanofi-aventis Group is listed in Paris (EURONEXT: SAN) and in New York
(NYSE: SNY). These statements include
financial projections and estimates and their underlying assumptions,
statements regarding plans, objectives and expectations with respect to future
operations, products and services, and statements regarding future
performance. Infant Pertussis: Who Was the Source? Pediatric
Infectious Disease Journal .

vaccinations masta

Over the last decade, 80% of pertussis deaths have occurred in infants under
six months of age .
"Over the last several years, the proportion of pertussis cases reported in
the U.S. Among
adults aged 20 years and older, the number of reported cases of pertussis
nearly doubled to 5,365 cases in 2004 from 2,854 cases in 2003.
In addition, studies were conducted that demonstrated that ADACEL vaccine
can be administered concomitantly with two other common adolescent and adult
vaccines - Hepatitis B (HB) and trivalent inactivated influenza.

About sanofi-aventis
The sanofi -aventis Group is the world's third-largest pharmaceutical
company, ranking number one in Europe.

Sanofi pasteur, the vaccines business of the sanofi-aventis Group, sold
nearly a billion doses of vaccine in 2004, making it possible to protect more
than 500 million people across the globe , which is about 1.

outbreaks traveldoctor

This correlates with the State Department's
statistics that China was the number six international destination for U.8 million American travelers. The
announcement today of the licensure of ADACEL vaccine follows a unanimous
recommendation on March 15 by the Vaccines and Related Biological Products
Advisory Committee (VRBPAC) of the U.5
days of school. Although sanofi-aventis ' management believes that the
expectations reflected in such forward-looking statements are reasonable ,
investors are cautioned that forward-looking information and statements are
subject to various risks and uncertainties, many of which are difficult to
predict and generally beyond the control of sanofi-aventis, that could cause
actual results and developments to differ materially from those expressed in,
or implied or projected by, the forward-looking information and statements. Pertussis in Newfoundland and Labrador, 1991-2004.

cholera typhoid

For information about Passport Health, go to http:/ /www. and LYON, France, Sanofi
pasteur, the vaccines business of the sanofi-aventis Group (NYSE: SNY),
announced today that the U. A children's diphtheria, tetanus and acellular pertussis (DTaP )
vaccine currently is recommended by the U.
In Canada, ADACEL vaccine is recommended for adolescents and adults.

Forward-Looking Statement
This press release contains forward-looking statements as defined in the
Private Securities Litigation Reform Act of 1995.

thrombosis outbreaks

An important health concern is that flu season occurs year-round in most
of China and peaks in southern China from April through November, just as
travel season heats up, according to travel health specialist and Passport
Health CEO Fran Lessans, RN, MS. First and Only Booster in the U.S.S.

(3) Bisgard KM, et al.

typhoid outbreaks

"Blanket travel health information is not wise for people going to
exotic destinations," says Ms.
Passport Health's diverse services include on-site flu clinics and
bioterrorism response."
The U.
This loss of productivity cost families an average of $767. Because intramuscular
injection can cause injection site hematoma, ADACEL vaccine should not be
given to persons with any bleeding disorder, such as hemophilia or
thrombocytopenia, or to persons on anticoagulant therapy unless the potential
benefits clearly outweigh the risk of administration. For more information , please visit:
http://www. 2004;39(11):1572-1580.com

vaccinations hemorrhagic

30 to 40 percent of Passport Health 's 65,000 clients went to Southeast Asia in
2005

BALTIMORE , Passport Health's national headquarters
in Baltimore reports that its business grew to approximately 65,000 travel
health client visits in 2005, with approximately 30 to 40 percent of clients
traveling to Southeast Asia.(2)
Adults often are the source of pertussis for infants and young children . In particular, adolescents and
adults have experienced a five-fold increase over the past 14 years . One study found that
the average medical costs for an infant with pertussis was more than $2,800 ,
while parents lost an average of six days of work to care for an ill child.(6)

Studies Support Safety and Immunogenicity
The U. Arch Fam Med.

dvt redbook

S.S. ADACEL vaccine is contraindicated in
persons with known systemic hypersensitivity to any component of ADACEL
vaccine or a life-threatening reaction after previous administration of the
vaccine or a vaccine containing the same substances .

diarrhea intending

S.com. Food and Drug Administration (FDA) has licensed
ADACEL(TM) (Tetanus Toxoid and Reduced Diphtheria Toxoid and Acellular
Pertussis Vaccine Adsorbed) Vaccine for protection against tetanus, diphtheria
and pertussis from adolescence through adulthood.
The number of reported cases of pertussis continues to rise across the
United States at a rate of great concern to the public health and medical
communities.
A 2004 study conducted by the U.

(7) Kandola, K.

cholera redbook

S. For example,
travelers to Nepal need to take precautions against altitude sickness, whereas
Chinese cities are polluted from wood and coal burning, which is very
irritating to the mucous membranes of the nose and mouth .(8) Sanofi pasteur intends to submit ADACEL vaccine for
licensure in other countries. Forward-looking statements
are statements that are not historical facts.6. Division of Bacterial and
Mycotic Diseases . Clin Infect Dis.
Manuscript in preparation.

fevers repellent

"As China welcomes more U.passporthealthusa.

malaria cholera

Founded in 1994, Passport Health is the largest private purchaser of
vaccinations in the United States, second only to the Federal Government.(3)
Health-care workers are of special concern for acquiring and transmitting the
disease because of their exposure to both infected and susceptible
individuals. In several regions, including the Northwest Territories and
Newfoundland, use of ADACEL vaccine started earlier than elsewhere in the
country, with reductions in pertussis disease noted within just a few years of
the vaccine's adoption. 2004; 23(11):985-989.