SAN JOSE, Calif. Herlihy,
President and Chief Executive Officer of Repligen. research on bipolar disorder and approximately one quarter of
the research on schizophrenia. Repligen has a Specialty Pharmaceuticals
business comprised of rProtein A(TM) and SecreFlo(R), the profits from which
will be used to partially support the development of our proprietary products. Such forward-looking statements are subject to a number of risks
and uncertainties that could cause actual results to differ materially from
those anticipated, including, without limitation , risks associated with: the
success of current and future collaborative relationships, the market
acceptance of our products, our ability to compete with larger, better
financed pharmaceutical and biotechnology companies, new approaches to the
treatment of our targeted diseases, our expectation of incurring continued
losses, our uncertainty of product revenues and profits, our ability to
generate future revenues, our ability to raise additional capital to continue
our drug development programs , the success of our clinical trials, our ability
to develop and commercialize products, our ability to obtain required
regulatory approvals, our compliance with all Food and Drug Administration
regulations , our ability to obtain, maintain and protect intellectual property
rights for our products, the risk of litigation regarding our intellectual
property rights, our limited sales and manufacturing capabilities , our
dependence on third-party manufacturers and value added resellers, our ability
to hire and retain skilled personnel, our volatile stock price, and other
risks detailed in Repligen's filings with the Securities and Exchange
Commission.

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They provide a level of
service to a target demographic not currently served by CRC. "If this proof of
principle study shows evidence that RG2417 improves the symptoms of bipolar
depression without inducing mania, it has the potential to be an important new
therapy in an area of significant unmet medical need.

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Barry Karlin, Chairman + CEO of CRC Health Group said, "The
acquisition of Sierra Tucson is a vital step in our strategy of building a
nationwide network of behavioral facilities serving the needs of all addicted
persons no matter where they are in the lifecycle of their disease or their
geographical location. The lifetime financial burden of bipolar disorder in the United
States is about $625,000 per patient, depending on resistance to treatment and
persistence of symptoms. SMRI funds approximately
half of all U.

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, CME LLC announced today the launch
of the Lifelong Learning Initiative on Bipolar Disorder, a full curriculum of
continuing medical education programs, running nationwide through December.com., Repligen Corporation
(Nasdaq: RGEN) today announced that the Company has initiated a Phase 2
clinical trial of RG2417, an oral formulation of uridine, in patients with
bipolar depression.

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S. Based in Irvine, Calif.CMELLC. WALTHAM, Mass. The rationale for uridine
therapy in neuropsychiatric disorders is supported by pre -clinical and
clinical research. The forward-looking statements in this release do not constitute
guarantees of future performance.

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CRC Health Group Announces Forthcoming Acquisition of Sierra Tucson; Premier Addiction Treatment Facility Joins Nation's Largest Substance Abuse Treatment Prov

Sierra Tucson is an outstanding organization and a
clinical powerhouse that has energized this industry."
CRC states that the purchase of Sierra Tucson is a perfect fit for CRC
Health Group's growth model that seeks to acquire programs that are well
established in their communities and have demonstrable records of clinical
excellence. The company is based in
Tucson, Arizona and operates a duly licensed , accredited special psychiatric
hospital and behavioral health center. (2003), J Clin
Psychiatry 64(1):53-58.

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Dr. It is my hope and belief that this step with CRC Health
Group will enable Sierra Tucson to reach ever greater heights and carry on our
tradition of clinical excellence and quality that we have so painstakingly
built since its inception.

About CRC Health Group
CRC Health is the nation's largest for-profit provider of drug and alcohol
treatment services and treats more than 30,000 people yearly. CRC provides lifelong care to adult and
adolescent patients through a continuum of services including detoxification,
residential treatment, day treatment , intensive outpatient programs, sober
living, community education, intervention and aftercare.S.

Consequently, 35 percent of bipolar
patients have to wait 10-12 years before receiving an accurate diagnosis.(3)
CME designed this learning initiative to positively impact earlier diagnoses
and ultimately help patients suffering from the disorder get the care they
need.S.

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Over the course of the last ten years, CRC has grown to 89
facilities in 20 states. Primary care physicians and other
healthcare professionals can register for events, participate in each
"Activity of the Month, " track credits and learn more about these important
patient care issues at http://bipolar.cmellc .

Repligen Initiates Phase 2 Clinical Trial of RG2417 for Bipolar Depression

"Bipolar depression is a serious chronic illness and treatment is
challenging due to the potential for induction of mania , a common side effect
of standard treatment with antidepressants," stated Walter C. This new
insight suggests that the symptoms of bipolar disorder may be linked to
dysregulation of energy metabolism of the brain.

This press release contains forward-looking statements which are made
pursuant to the safe harbor provisions of Section 27A of the Securities Act of
1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as
amended.

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About Sierra Tucson
For twenty-two years Sierra Tucson has provided unparalleled behavioral
health care that emphasizes healing the whole person. The need for such
education is evident by the fact that 69 percent of bipolar patients are
misdiagnosed-usually with major depression-which can have life-altering
consequences. Although lithium and anticonvulsants such as
valproic acid have substantially improved the prognosis of bipolar disorder,
many individuals are unable to tolerate treatment-related side effects, and
incomplete clinical response, relapse, and recurrence remain common clinical
problems. Schizophrenia and bipolar disorder are the
major psychiatric disorders in the United States, affecting more than 4
million people.

Support groups for people with mental health conditions.

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, CRC Health Group, the nation's
largest alcohol and drug abuse treatment provider, today announced the signing
of a definitive agreement to purchase Sierra Tucson, one of America's premier
behavioral treatment facilities.
CRC expects to complete the transaction in the next couple of months. CRC has extended its
presence to the Internet with eGetgoing, an online substance abuse treatment
platform.

About CME LLC
CME LLC is a leading ACCME-accredited provider of continuing medical
education programs and offers a wide range of informational and educational
resources for healthcare professionals., CME produces
a variety of conferences, multimedia home-study products and Web sites and is
the sponsor of the U. For additional information, visit CME online at
http://www.

1.S.

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CRC's
corporate leadership seeks to preserve and expand that which is excellent and
add value through treatment innovation and industry leadership. Lifelong Learning Initiative Provides New Tools and Insights for Earlier
Diagnosis, Collaborative Care

IRVINE, Calif. Bipolar disorder
is a chronic illness associated with substantial morbidity and mortality,
ranking worldwide behind only unipolar depression and alcohol abuse among
psychiatric illnesses for related disabilities and overall economic burden of
illness.

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The Lifelong Learning Initiative on Bipolar Disorder shares vital new
findings with primary care physicians around the country by focusing primarily
on two components: methods for identifying and diagnosing bipolar disorder and
emerging best practices for treating the illness.
CME's Lifelong Learning Initiative on Bipolar Disorder is supported by an
unrestricted educational grant from AstraZeneca. Patients will be evaluated for the safety and effectiveness of RG2417
on the symptoms of bipolar depression. This study is being conducted under a
development agreement with the Stanley Medical Research Institute, under which
Repligen will receive approximately $1,000,000 in funding.

About The Stanley Medical Research Institute
The Stanley Medical Research Institute (SMRI) is a nonprofit organization
that supports research on the causes and treatment of schizophrenia and
bipolar disorder (manic-depressive illness), both through work carried out in
its own laboratories and through support of researchers worldwide who are
working on these diseases.

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Individual events include half-day meetings and dinner
meetings , teleconferences, online programs, enduring supplements and other
multimedia activities that cover such critical issues as diagnostic strategies
for bipolar disorder, safety and efficacy of available therapies,
collaborative care, and many others.
Bipolar disorder affects more than two million adults in the United States and
is usually diagnosed in late adolescence or early adulthood. SMRI is the largest nonprofit provider of research
funding for schizophrenia and bipolar disorder in the United States and has
provided over $200 million in funding since 1999.

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"Patients frequently seek a physician's
care when they're in a state of depression, not elated with mania-the other
hallmark of bipolar disorder-so without careful assessment to uncover the full
spectrum of patients' histories , physicians often misdiagnose them as
suffering solely from major depressive disorder rather than bipolar disorder. While primary
care physicians are often the first to recognize depression in their patients,
symptoms of bipolar disorder can resemble those related to schizophrenia,
borderline personality or even ADHD.

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"
Bill O'Donnell, Founder and Chairman of Sierra Tucson added, "I am
extremely proud of what we have accomplished at Sierra Tucson over the last
twenty-two years.

com
For more information about Sierra Tucson: http://www.sierratucson.repligen.

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(1 )
"Research clearly shows that bipolar disorder is among the most difficult
illnesses to diagnose ," said Marsha Meyer, RPh, senior vice president of
clinical information for CME LLC. An ongoing outcomes study will be
conducted prior to, immediately after and three to six months following the
completion of the full curriculum."
Repligen previously completed a 6-week Phase 1 clinical trial of a prodrug
of uridine (RG2133) in patients with bipolar disorder or major depression.
The results demonstrated that administration of RG2133 in this patient
population appeared to be safe , did not induce mania, and provided early
evidence of a clinical effect of the drug.

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Each new acquisition adds its unique brand of
excellence to CRC's network."
Recent studies show that approximately five percent of the U. CME's Lifelong Learning Initiative on Bipolar
Disorder fills a critical void in medical education, bringing primary care
clinicians the latest psychiatric findings on this disorder , as they are
usually a patient's first point of contact.

3. This Phase 2 study is a multi-center, dose escalating
study in which 80 patients will receive either RG2417 or a placebo for 6
weeks. The Stanley
Medical Research Institute is the largest nonprofit provider of funding for
research on schizophrenia and bipolar disorder in the United States. The trial evaluated 19 patients
and was carried out by investigators at McLean Hospital, the largest
psychiatric clinical care, teaching and research affiliate of Harvard Medical
School.
Repligen's corporate headquarters are located at 41 Seyon Street, Building #1,
Suite 100, Waltham, MA 02453. Repligen assumes no obligation to update any forward-looking
information contained in this press release or with respect to the
announcements described herein.

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CME LLC Offers Primary Care Physicians the Latest Insights on Bipolar Disorder

population
struggles with bipolar disorder (2), a much higher incidence than previously
estimated, but strides have been made that make efforts to diagnose this
disorder much more effective . Investors are cautioned that statements in
this press release which are not strictly historical statements, including,
without limitation, statements regarding current or future financial
performance and position, management's strategy, plans and objectives for
future operations, plans and objectives for product development, plans and
objectives for present and future clinical trials and results of such trials,
plans and objectives for regulatory approval, litigation, intellectual
property , product development, manufacturing plans and performance such as the
anticipated growth in the monoclonal antibody market and our other target
markets and projected growth in product sales, constitute forward -looking
statements.

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These facilities range in age from twenty to
forty years of treatment leadership in their respective communities. The
acquisition of Sierra Tucson will further establish CRC's leading position in
the alcoholism and drug abuse treatment arena.crchealth. The curriculum also
provides insights on the benefits of collaboration between primary care and
mental health specialists in treating this complex illness. Psychiatric + Mental Health Congress and the Issues in
Aging Medical Congress .

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For more information about CRC Health Group: http://www.com

2. Hirschfeld RM, Calabrese, JR, Weissman MM et al. Recent
reports indicate that certain genes that encode for mitochondrial proteins are
significantly down-regulated in the brains of bipolar patients.com.

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75 credits.com. Uridine is synthesized by the power
plant of the human cell known as the mitochondria.

About Bipolar Disorder
Bipolar disorder, also known as manic depression , is an illness marked by
extreme changes in mood, thought, energy and behavior in which a person 's mood
can alternate between the "poles" of mania (highs) and depression (lows).

About Repligen Corporation
Repligen Corporation is a biopharmaceutical company committed to being the
leader in the development of novel therapeutics for profound neuropsychiatric
disorders and autoimmune disease.

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According to a 2000 survey by the National Manic and Manic-Depressive
Association .

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Each educational activity highlights a
particular aspect of bipolar disorder and provides clinicians with a complete
overview of this pervasive, highly misdiagnosed illness.
Clinicians are encouraged to participate in as many activities as possible
to receive the full educational benefit of this curriculum, while earning as
many as 29.
Uridine is a biological compound essential for the synthesis of DNA and
RNA, the basic hereditary material found in all cells, and numerous other
factors essential for cell metabolism.

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Programs offered include a full
continuum of addiction services (substance abuse, gambling, sexual), a
renowned eating disorder program, and treatment for depression , anxiety and
emotional trauma.

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The company is
based in San Jose, California and operates residential , outpatient and opiate
treatment centers throughout the U.
The Lifelong Learning Initiative is geared toward primary care physicians and
addresses the importance of a collaborative approach to the diagnosis and
management of bipolar disorder along with the latest findings in screening and
best practices regarding treatment. Hirschfeld RM, Lewis L, Vornik LA (2003), J Clin Psychiatry 64(2):
161-174. Researchers at McLean Hospital previously demonstrated
that uridine is active in a well-validated animal model of depression. Additional information may be requested from
http://www.

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