R.html. The new
microarray can detect such gene defects on chromosome 11 and other genetic
regions implicated in neuroblastoma.S.

About The Children's Hospital of Philadelphia: The Children 's Hospital of
Philadelphia was founded in 1855 as the nation's first pediatric hospital.

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The research agreement between Xenomics and Eastern Virginia
Medical School (EVMS) of Norfolk, Va.trilogy-capital .D.

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One of the most populous regions of
Virginia, Hampton Roads' largest cities include Chesapeake , Hampton,
Newport News, Norfolk, Portsmouth, Suffolk and Virginia Beach. The Company believes that its
technology will open significant new markets in the molecular
diagnostics field.com/tcp/xenomics .html.-- Microarray Scans DNA Regions in Neuroblastoma Tumors to Forecast Outcomes,
Guide Treatments --

PHILADELPHIA, Genetics researchers have developed a
customized gene chip to rapidly scan tumor samples for specific DNA changes
that offer clues to prognosis in cases of neuroblastoma, a common form of
children's cancer.D. This is a signal that a
particular gene variation is present in the sample.,
professor of medicine and Associate Director of Research at the Cardeza
Foundation for Hematologic Research and the Division of Hematology at
Jefferson Medical College.

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These are required studies that we expect will
lead to application to the FDA for approval, and ultimately to deliver
those products to the marketplace," said Dr. For more
investor -specific information, including daily and historical Company
stock quote data and recent news releases , please visit
http://www. To view an
online video about Xenomics technology and products, visit
http://www.

Customized Gene Chip Provides Rapid Detection of Genetic Changes in Children's Cancer

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EVMS works in
partnership with hospitals, physicians, and clinics throughout the
region, providing students and residents with a broad base of clinical
experience. For more information, please visit
http://www. Identifying the
correct risk level allows doctors to treat aggressive cancers appropriately ,
while not subjecting children with low-risk cancer to overtreatment.
Unlike gene expression microarrays, which detect varying levels of RNA to
measure the activity levels of different genes as DNA transfers information to
RNA, the current microarray directly identifies changes in DNA., of Orchid Biosciences, Princeton, N.

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Steven Warsof, Associate Professor and Director of Genetics
and Prenatal Diagnosis at the Center for Advanced Fetal Therapy at
EVMS, who will serve as principal investigator on the trials, said the
several-month-long study will examine the urine of pregnant women to
detect the presence of four major chromosomal abnormalities, as well
as gender information ."
Equally important, the Xenomics Tr-DNA tests might be able to be
performed as early as only 8 weeks into pregnancy -- much earlier than
is possible with amniocentesis, or other tests such as the triple
screen which are typically performed 16-22 weeks into pregnancy.
In contrast, the amniocentesis procedure must be conducted in a
medical facility. The Company has organized a joint venture to conduct
research on infectious disease detection with the National Institute
for Infectious Diseases (Instituto Nazionale per le Malattie Infettive
"Lazarus Spallanzani") in Rome, in the form of a new R+D company
called SpaXen Italia, S.chop.

Contacts: Rachel Salis-Silverman
The Children's Hospital of Philadelphia
(267) 426-6063
Salis@email.

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"The urine samples and cooperative research that Eastern
Virginia Medical School will conduct is expected to provide important
data about the potential to use our Transrenal-DNA platform to create
valuable medical tests."
Transrenal-DNA is DNA that has passed through the kidneys and is
eliminated in the urine.trilogy-capital. Although Xenomics believes that the expectations
reflected in such forward-looking statements are reasonable, it can
give no assurance that such expectations reflected in such
forward-looking statements will prove to be correct. When DNA bases from
a sample bind to complementary sequences on the microarray, they cause
fluorescent tags to shine under laser light.

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The clinical study is subject to
review and approval by the institutional review board of EVMS. Randy White, CEO of
Xenomics. In particular,
urine analysis offers none of the risks, discomforts or costs
associated with amniocentesis, in which amniotic fluid is extracted
through a nine-inch needle inserted into the uterus, to obtain fetal
DNA.
"We have customized this tool for neuroblastoma, but the approach might
also be adapted to other types of cancer in which DNA changes are important,"
said co-author Paolo Fortina, M.
Cancer researchers have pinpointed specific genetic abnormalities that
influence the aggressiveness of neuroblastoma.edu

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The Company is working to
develop simple urine analysis tests based on its Tr-DNA technology to
detect a range of prenatal genetic abnormalities, including Down
syndrome, as well as other questions of genetic makeup.trilogy-capital.
The investigators, from The Children's Hospital of Philadelphia and Thomas
Jefferson University, say their technique may be readily adapted for other
types of cancer.D.
"We can test DNA from peripheral blood and from the tumor, and we should
see a loss of signal in the cancer," said Dr. He noted that the
researchers can simultaneously evaluate seven chromosomal regions known to be
involved in neuroblastoma.

hmsn chromosomal

Scientists from Xenomics were the first to
report that fragments of DNA from normal cell death cross the kidney
barrier and can be detected in urine. As discussed in
the periodic reports of Xenomics, as filed with the Securities and
Exchange Commission, actual results could differ materially from those
projected in the forward-looking statements as a result of the
following factors, among others: uncertainties associated with product
development , the risk that Xenomics will not obtain approval to market
its products, the risk that Xenomics' technology will not gain market
acceptance, the risks associated with dependence upon key personnel ,
and the need for additional financing. Gelfand, Ph.jefferson.edu.

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It demonstrates our strong progress in continued execution
of our business plan to develop products based on our Tr-DNA
technology platform. Warsof. For more information, visit
http://www.

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"Starting these human trials is an important next step forward for
Xenomics.
Xenomics' patented technology uses safe and simple urine collection
and can be applied to a broad range of applications, including
prenatal genetic testing, tumor detection and monitoring, tissue
transplantation, infectious disease detection, genetic testing for
forensic identity determination, drug development, and research to
counter bioterrorism.com/tcp /xenomics/factsheet. A TV news
report about the Company's next-generation prenatal tests can be
viewed at http://www."
One advantage of their technique is its flexibility, said co-author John
M . Fortina. If a clinical diagnosis isn't known, the method
might provide some clues.
In addition to Drs. White, Ph.edu

Steve Benowitz
Thomas Jefferson University
(215) 955-6300
steven.

palatal chromosomal

Business Editors/Health/Medical Writers

NEW YORK----Xenomics, Inc. To read or download the
Company's Investor Fact Sheet, visit
http://www. Rather than covering the entire genome, the microarray
focuses on suspect regions of chromosomes for signs of deleted genetic
material known to play a role in the cancer.
Through its longstanding commitment to providing exceptional patient care,
training new generations of pediatric healthcare professionals and pioneering
major research initiatives, Children's Hospital has fostered many discoveries
that have benefited children worldwide.

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, for a collaborative clinical
study that will investigate the ability of Xenomics' Transrenal-DNA
(Tr-DNA) to detect a number of fetal genetic problems through analysis
of urine samples of pregnant women.trilogy-capital.
When the gene involved is a tumor suppressor gene, LOH removes a brake on
uncontrolled cell growth, the growth that is the hallmark of cancer., and Eric Rappaport, Ph. Thomas Jefferson University Hospital, part of the academic
health center complex, admits more than 40,000 patients a year for advanced
treatment and care .

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Currently, many
patients are having invasive testing such as amniocentesis or
chorionic villi sampling, that puts their pregnancy at some risk, and
that risk could be eliminated with this technology .

Xenomics is a molecular diagnostic company that focuses on the
development of DNA-based tests using Transrenal-DNA (Tr-DNA).com/tcp/xenomics/video.
The most common cancer found in infants , neuroblastoma strikes the
peripheral nervous system, often appearing as a solid tumor in a child 's chest
or abdomen.

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Additionally,
Xenomics is developing tests for infectious diseases such as AIDS and
tuberculosis. "To
know the answers to these questions about the chromosomal health of
the fetus would bring parents much more peace of mind and reduce their
anxiety about the pregnancy ," said Dr.
Warsof.trilogy-capital., a pediatric oncologist at The Children's Hospital of
Philadelphia . In addition, its unique family-centered care and public
service programs have brought the 430-bed hospital recognition as a leading
advocate for children and adolescents.

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Xenomics also recently announced execution of a research agreement
with North Shore-Long Island Jewish Health System, one of the nation's
largest healthcare institutions, to conduct human clinical trials of
its technique to detect Down syndrome in unborn children through
analysis of maternal urine samples. Xenomics scientists discovered that it is
possible to detect genetic material of fetal origin that passes
through the mother's kidneys into her urine. The proof-of-principle study appears in the August issue of
"Genome Research.
Microarrays are silicon chips that contain tightly ordered selections of
genetic material upon which sample material can be tested.
The microarray described in the paper has only been used in their
laboratory study, but the researchers hope that with further study it may
become more widely available as a diagnostic tool for oncologists treating
patients with neuroblastoma , and possibly for other cancers. Grants from the National
Institutes of Health and the Children 's Oncology Group supported the work. For more information, visit
http://www.chop.benowitz@jefferson .

chromosome hnpp

(OTCBB:XNOM), a developer of next-generation medical DNA technologies,
has executed a contract with Eastern Virginia Medical School, a
leading healthcare and educational institution, to begin human
clinical trials of the Company's proprietary diagnostic DNA technology
for the creation of completely safe and non-invasive prenatal tests
for a range of genetic abnormalities, such as Down syndrome.
Dr.com/tcp/xenomics/ny1_video. Maris, M. An important abnormality is
loss of heterozygosity (LOH), the deletion of one copy of a pair of genes. "These DNA
changes, involving gain or loss of genetic material, are important for
neuroblastoma prognosis," said Dr.

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The first amniocentesis for prenatal diagnosis was
conducted in 1972."

About Eastern Virginia Medical School

Eastern Virginia Medical School serves the region of southeastern
Virginia known as Hampton Roads. "As future research identifies other genes active in
neuroblastoma, we can modify the microarray to include such regions," he
added.
Researchers in Dr.D., and Shobha
Varde, M. Its pediatric research program is
among the largest in the country, ranking second in National Institutes of
Health funding .

About Thomas Jefferson University: Thomas Jefferson University is composed
of three schools -- Jefferson Medical College, the Jefferson College of
Graduate Studies and the Jefferson College of Health Professions. The three
colleges enroll more than 2,300 future physicians, scientists and health-care
professionals.

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Xenomics Signs Research Agreement with Eastern Virginia Medical School to Conduct Human Trials of Prenatal Tests for Genetic Abnormalities; Proprietary Transre

Xenomics scientists believe the Company's Tr-DNA technology can
enable the creation of prenatal tests that are more accurate, more
informative and can be conducted much earlier in pregnancy than
existing DNA analysis methods, such as amniocentesis. For the region as a whole, these educational partnerships
spread the benefits of an academic medical center throughout the
region, improving the quality of life and the quality of health care
for the entire community.html

Forward-Looking Statements

Certain statements made in this press release are forward looking., professor of medicine at Jefferson
Medical College of Thomas Jefferson University in Philadelphia and section
chief, Genomics and Diagnostics, in the Jefferson Department of Medicine's
Center for Translational Medicine. Some types of neuroblastoma are low risk, resolving after surgeons
remove the tumor, while others are much more aggressive. Maris' laboratory previously established that LOH in a
region of chromosome 11 allows aggressive neuroblastoma to take hold. Maris, Fortina, and Surrey, other co-authors are
George Hii, Peter S.J.edu.

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The
main campus of EVMS is located in Norfolk, Virginia.L.

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"A simple urine test for prenatal genetic screening
would be the culmination of 40 years of scientific inquiry ," added Dr. "It's what we have been striving for since prenatal diagnosis
has been available.edu

About Xenomics, Inc.com/tcp/xenomics/website.D. Maris.D.D.

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"If successful, it
could revolutionize all of prenatal diagnostics. Warsof. Xenomics has three issued U. patents covering
different applications of the technology for molecular diagnostics and
genetic testing and a pending European patent for the same
applications.

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"Also, it could bring
medicine's prenatal diagnosis powers within reach of virtually any
women anywhere in the world, since it requires only the collection of
a urine sample and delivery to a laboratory.S.html., Ph.
In pinpointing specific regions of chromosomes with loss in DNA, the
technology may help confirm a clinical diagnosis, said Saul Surrey, Ph. Founded in 1824, Jefferson Medical College is one of the
largest private medical colleges in the nation, with among the largest living
alumni groups. For more information, visit http://www.

chromosome translocations

"For a prenatal diagnostician the Xenomics technology is the holy
grail of prenatal diagnostics," said Dr.evms.
Such statements are indicated by words such as "expect," "might,"
"should," "anticipate" and similar words indicating uncertainty in
facts and figures., of The
Children's Hospital of Philadelphia; and Craig A.