S.

Dengue fever or dengue hemorrhagic fever is a viral disease transmitted by
mosquitoes.

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Annan.
IAVI ( http://www.iavi.

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Five
microbicide candidates have entered or are about to enter large-scale efficacy
trials this year.

Cyto Pulse Sciences , Inc.

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The same must be done to develop an
effective microbicide.
Today, the AIDS vaccine field is making renewed progress towards a preventive
vaccine with new scientific efforts underway with over 30 vaccine candidates
in 20 countries."
Financial support for AIDS vaccine research and development (R+D) is
predominately provided by the public sector. Zeda Rosenberg, who is a Harvard -trained
microbiologist and public health advocate. Easy Vax(TM) solves the
delivery problem.

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Given current scientific advancements
and the identification of a number of potential microbicidal agents, an
effective microbicide could be developed by the end of the decade.
The agreement , signed in March 2005, is for a three-year project.

The history of public health including large public health campaigns.

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"
Discussions focused on promising new preventive technologies such as
microbicides , products in a gel, cream, or ring that could be applied
topically to genital mucosal surfaces to reduce the transmission of HIV during
sexual intercourse. Microbicide development is advancing rapidly .

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Both AIDS vaccines
and microbicides could help to end the epidemic and increase the power of
women to protect themselves from HIV infection. Founded in 1996 and operational in 23 countries, IAVI and its
network of collaborators research and develop vaccine candidates. It is a devastating infection which is rapidly expanding in most
tropical and subtropical areas of the world.

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"As things stand , we are still years away from a
microbicide or vaccine.

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"As we have seen in India, it is vital for emerging economies to build
capacity to conduct research, which can have benefits well beyond the trials
themselves," said Kapil Sibal, Minister of Science and Technology from India. Ninety percent of this funding
comes from governmental sources with 90% of that total coming from the United
States , including the recent increase in funding from the U.org ) seeks to deliver a safe and
effective microbicide for women in developing countries as soon as possible.

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Call for World Leaders to Redouble Efforts to Develop Vaccines and Microbicides to Prevent HIV

IPM is led
by Chief Executive Officer Dr.org ) is a global not-for-profit organization
working to accelerate the development of a vaccine to prevent HIV infection
and AIDS.cytopulse.

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"HIV infection rates among women have risen dramatically in recent
years. is a medical device company developing and
manufacturing systems used in monoclonal antibody production, gene therapy,
vaccine production and delivering the new safe DNA/nucleic acid vaccines using
its Easy Vax(TM) system.

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Next month, leaders from the G8 nations will review progress made since
last year's endorsement of the Global HIV Vaccine Enterprise, an alliance of
independent organizations committed to accelerating the development of a
preventive HIV vaccine . Donors to IPM include the
Governments of Canada, Denmark, Ireland, the Netherlands, Norway, Sweden , the
United Kingdom, and the United States as well as the European Commission, the
Bill + Melinda Gates Foundation, the Rockefeller Foundation, the World Bank
and the United Nations.

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"Leaders within emerging economies should integrate vaccine and microbicide
development into their comprehensive responses to HIV/AIDS. IAVI also
advocates for a vaccine to be a global priority and works to assure that a
future vaccine will be accessible to all who need it. GLEN BURNIE, Md. (Cyto Pulse) of Glen Burnie, MD to develop a DNA
vaccine delivery system against Dengue fever. The CDC calls it the most
important arboviral (mosquito or tick-borne) disease of humans.

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NEW YORK, Thursday, June 2, 2005 - Researchers and
international leaders at the United Nations General Assembly High -Level
Meeting on HIV/AIDS today called on governments around the world to complement
their existing efforts with a focus on developing new technologies, such as
microbicides and vaccines, to prevent the spread of HIV. Preventive vaccines have been key to curbing viral epidemics
in the past, such as polio, smallpox, measles, and more than a dozen others."
"The world needs better long-term solutions to the HIV pandemic," said
Seth Berkley, MD, President and CEO of IAVI. Zeda Rosenberg , CEO of
IPM.
"The world needs to act now to commit the resources and political will to
scale up research and development for HIV vaccines and microbicides," said Dr
Peter Piot, Executive Director of the Joint United Nations Programme on
HIV/AIDS (UNAIDS)., The Walter Reed Army Institute
of Research (WRAIR), Silver Spring, MD, has entered into an agreement with
Cyto Pulse Sciences, Inc .

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ipm-microbicides.
IPM identifies the most promising technologies and invests its resources to
help develop them into usable products. DNA/nucleic acid vaccines provide a total immunity
similar to live virus vaccines and are much safer, but they must be delivered
directly into the patient's immune system cells.
Additional information on Cyto Pulse Sciences, Inc.

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Health and science ministers from Brazil and India and representatives
from Rwanda joined with UN leaders and the heads of the International
Partnership for Microbicides (IPM) and the International AIDS Vaccine
Initiative (IAVI) to discuss the importance of new HIV prevention technologies
and to address the stigma challenges that often undermine national efforts to
confront the disease. Developing technologies, including an effective microbicide whose use
could be initiated by women, is a crucial step in combating the AIDS
epidemic."

CONTACTS:
IAVI: Jannette Esguerra, 212-847-1045 or 917-604 -0141,
jesguerra@iavi.

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Harnessing the talents of researchers in heavily-affected
countries , speeding regulatory and trial processes, and working with
communities will produce better technologies sooner.org

IPM ( http://www. Haas Charitable Trust B. WRAIR
and Cyto Pulse Sciences desire to cooperate in research and development of
methods for the administration of Flavivirus (Dengue ) vaccines using a pulsed
electric field delivery system. The new agreement continues that collaboration with testing of an
improved, second generation DNA vaccine delivered by Cyto Pulse's new Easy
Vax (TM) delivery system.

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"Greater collaboration --
particularly between the North and the South -- is making a significant
difference. The company's technology provides the degree of safety,
repeatability and efficiency required for commercial and clinical use.

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Other important sources of support include philanthropic
foundations, such as the recent commitment by the Bill + Melinda Gates
Foundation . The public sector contributed 85% of the total funds, 75% of which
came from the United States .
The views expressed are those of the authors and should not be construed
to represent the positions of the Department of the Army or Department of
Defense. is available at the
company 's website, http://www.

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org
Ellena Friedman, 212-847-1090 or 646-775-1973,
efriedman@iavi.

CONTACT: Cyto Pulse Science, Inc.

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"
"Vaccines offer the best long-term solution to the epidemic, and
microbicides, which could be ready in 5-7 years, offer hope to the growing
number of women who are vulnerable to HIV," said Dr. New incentives to increase industry engagement,
which are currently being discussed in the field, are critical. Sloan and Starr Foundations; the Governments
of Canada, Denmark, the European Commission, Ireland, the Netherlands, Norway,
Sweden , the United Kingdom and the United States; multilateral organizations
such as the World Bank; corporate donors including BD (Becton, Dickinson +
Co. The Cyto Pulse Sciences vaccine delivery
system uses an array of hundreds of small needles, each one coated with the
DNA vaccine.
Work under a previous agreement with WRAIR demonstrated the protective
efficacy of a prototype dengue-1 DNA vaccine using electric field-mediated DNA
delivery.

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"There has been considerable progress in the search for a vaccine against
HIV, but we do not yet have a viable one," said Secretary General Kofi A. "To succeed, we must focus resources on basic research and engage
communities around prevention trials. Every year HIV infections continue to grow and
millions more lives are lost to this epidemic . The battle against AIDS can be
won, but we must invest in the tools we need to accomplish this goal .), Continental Airlines and DHL; leading AIDS charities such as Crusaid,
Deutsche AIDS Stiftung, and the Until There's A Cure Foundation; and other
private donors such as the Phoebe W.

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National
Institutes of Health.org
IPM: Martin Methot, 301-608-2221 or 240-381-1274,
mmethot@ipm-microbicides.

Cyto Pulse Sciences Inc. Working With Walter Reed Army Institute of Research for Dengue Fever Vaccine Delivery Development

An electric field allows the DNA to enter immune system cells in
the skin, specifically the dendritic cells involved in immune system response.

epidemics 1785

IAVI's financial and
in-kind supporters include the Bill + Melinda Gates Foundation, the
Rockefeller Foundation , Alfred P., +1-410-787-1890.

clendening epidemics

At the same time, we must also step up prevention
efforts and strengthen infrastructure to ensure that when an AIDS vaccine or
microbicide becomes available, people everywhere will have immediate access --
especially those who need it most. In 2004, approximately $140 million was committed to microbicide
research. In the lead-up to the G8 summit in Scotland next
month , the importance of continued support for HIV vaccines and microbicides
has been reiterated.com.