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During the 2005 Association for Research in Vision and
Ophthalmology (ARVO) Annual Meeting in Fort Lauderdale, FL from May
1-5, Regeneron will present clinical data in a poster entitled "A
double-masked, placebo-controlled, dose-escalating phase 1 study of
intravenous VEGF Trap in patients with neovascular age-related macular
degeneration: evaluation of safety, tolerability, visual acuity, and
ocular coherence tomography (OCT).
Also at ARVO, Regeneron scientists will present eight posters
describing the results of pre-clinical research on the use of the VEGF
Trap to treat multiple eye diseases.
Additional Information about Regeneron and recent news releases
are available on Regeneron's Worldwide Web Home Page at
www.

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This news release discusses historical information and includes
forward-looking statements about Regeneron and its products, programs,
finances, and business, all of which involve a number of risks and
uncertainties , such as risks associated with preclinical and clinical
development of drugs and biologics, determinations by regulatory and
administrative governmental authorities, competitive factors,
technological developments, the availability and cost of capital, the
costs of developing, producing, and selling products, the potential
for any collaboration agreement to be canceled or to terminate without
any product success, and other material risks.
Nasal irrigation is an important health issue for everyone. Americans
neglect their nasal hygiene -- despite the fact that proper nasal health is as
important to respiratory health as tooth brushing is to oral health -- leaving
their respiratory systems more vulnerable to the millions of potentially
harmful contaminants that are an increasing problem in modern society,
according to the recent Nasal Comfort survey of consumers nationwide.

Research published in medical journals including
"Otolaryngology-Head and Neck Surgery, Journal of Family Practice, The
Laryngoscope, and American Family Physician" indicates that cleansing the nose
by using a hypertonic saline nasal spray can help reduce both the amount and
contact time with harmful agents.D., FACS, Associate Clinical Professor of Otolaryngology-Head +
Neck Surgery at Columbia University College of Physicians + Surgeons.

* Spray Every Day: Clinical studies show that nasal cleansing with a
nasal hypertonic saline solution effectively promotes proper nasal
health by cleansing, clearing, moisturizing and, overall, making
breathing easier .

* Evaluate Your Nose: Do a "breathing test" for nasal health. Nasal washing involves pouring solution directly into
the nose and the solution flows out the other nostril.

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Jakob Dupont, a
medical oncologist at Memorial Sloan-Kettering Cancer Center, will
present a poster titled "Safety and pharmacokinetics of intravenous
VEGF Trap in a phase 1 clinical trial of patients with advanced solid
tumors.
During the Annual European Congress of Rheumatology in Vienna from
June 8-11, sponsored by the European League Against Rheumatism
(EULAR), data will be presented on the IL-1 Trap. The oral
presentation will include data from a phase 2 study in patients with
CIAS1-Associated Periodic Syndrome (CAPS ), which was funded in part by
the National Institute of Arthritis and Musculoskeletal and Skin
Diseases , part of the National Institutes of Health. The ceremony will be held on February 8, 2006 and
broadcast domestically by the CBS Television Network (8 p. "As an
ear, nose and throat doctor, I treat many different types of patients who
would benefit from using nasal sprays on a daily basis. Nasal Comfort is hypertonic, containing
2.matrixxinc.

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A more complete
description of these risks can be found in Regeneron's filings with
the United States Securities and Exchange Commission, including its
Form 10-K for the year ended December 31, 2004.
Physicians often recommend nasal cleansing as a means of maintaining good
nasal health and hygiene."

The Daily N.

This section provides links to various health products and shopping places.

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Also,
according to scientists at Sweden's Karolinska Institute, humming --
producing a tune without opening the lips -- is an effective way to
increase ventilation in the sinuses and reduce blockage.

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About Regeneron

Regeneron is a biopharmaceutical company that discovers, develops,
and intends to commercialize therapeutic medicines for the treatment
of serious medical conditions.

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Inhale
deeply through the nose and feel the difference proper nasal health can
make to your overall health and well -being.

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Regeneron also announced that it has completed small pilot studies
in healthy volunteers examining the effects of the IL-1 Trap on a
systemic marker of inflammation.

Celebrities Find Nasal Comfort in the 48th Annual GRAMMY(R) Awards Gift Basket for Presenters and Performers

ET/PT).

* Nose Breathing is Best: Breathing through the nose is nature's way of
filtering and warming the air you breathe before it reaches the lungs.5% sodium chloride, greater than that of the nasal tissue, which draws
excess fluid from the nasal tissues. To find out more
about Matrixx Initiatives, Inc (Nasdaq: MTXX), visit our website at
http://www.

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About Nasal Comfort Moisture Therapy
Nasal Comfort contains all of the elements that healthcare professionals
recommend most from a nasal solution.com.

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As the guardian of the
respiratory tract the nose cleans and moistens the air passages," said Daniel
B.
Designed to increase consumer compliance, Nasal Comfort offers an
effective and convenient alternative to traditional nasal cleansing methods
such as nasal washing. The Company's
flagship product Zicam Cold Remedy nasal gel, is a patented, homeopathic
remedy that has been clinically proven to reduce the duration and severity of
the common cold . For more information
regarding Matrixx products, go to http://www.

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(Nasdaq: REGN) announced today that data from
clinical and pre-clinical studies of the VEGF and IL-1 Traps will be
presented at three upcoming medical conferences in May and June.O.S.

* Open Your Airway: Keep your nasal passages open with a quick steam
clean or when very congested, use a topical nasal decongestant spray. The Company also
manufactures and markets a full line of Zicam brand pharmaceuticals, including
Zicam Cold Remedy Chewables(TM); Zicam Cold Remedy Oral Mist(TM); Zicam Cold
Remedy RapidMelts (TM); Zicam Allergy Relief; Zicam Cold Remedy Swabs(TM);
Zicam Kids Size Cold Remedy Swabs(TM); Zicam Extreme Congestion Relief; Zicam
Sinus Relief; Zicam Nasal Moisturizer, as well as seven Zicam Cough Mist(TM)
products and four Zicam Cold + Flu relief items.

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Regeneron has therapeutic candidates in
clinical trials for the potential treatment of cancer and eye
diseases, rheumatoid arthritis and other inflammatory conditions and
asthma and allergies and has preclinical programs in other diseases
and disorders. is engaged in the development, manufacture and
marketing of over-the-counter healthcare products that utilize innovative drug
delivery systems.

Sites for products or sales of health products should be submitted to Shopping/Health_and_Beauty

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Kuriloff, M.
Mouth breathing allows impurities and contaminants to enter the
respiratory system and leaves you vulnerable to their adverse effects. So, try
humming a happy tune for nasal health.

About Matrixx Initiatives
Matrixx Initiatives, Inc.

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----Regeneron
Pharmaceuticals, Inc. Kuriloff developed an exclusive daily
nasal health regimen to educate consumers and promote proper nasal health.
Moist heat helps drain mucus from the sinuses to clear the nose. This is a process that
many people consider awkward and messy.

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Business Editors/Health/Medical Writers
BIOWIRE2K

TARRYTOWN, N." Regeneron and sanofi-aventis are also collaborating on the
development and commercialization of the VEGF Trap in oncology. In studies published in the October 2000 issue of ENT --
"Ear, Nose and Throat Journal," and separately in the January 2003 issue of
"QJM: An International Journal of Medicine ," the Zicam Cold Remedy product was
shown to reduce the duration of the common cold.com.

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The Company plans to submit the
results of these studies for presentation in an abstract at a
cardiovascular conference later this year and for publication in a
peer-reviewed medical journal.

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regeneron. Clinical evidence
suggests that hypertonic nasal sprays such as Nasal Comfort offer additional
benefits , and I would recommend this formulation to all of my patients. Regimen
To address this health issue, Dr.

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Regeneron is independently
developing the VEGF Trap in eye diseases utilizing local delivery
systems, such as intraocular injections. Regeneron does not
undertake any obligation to update publicly any forward-looking
statement, whether as a result of new information, future events, or
otherwise unless required by law.com

Regular Nasal Irrigation With a Hypertonic Saline Spray for Vocalists
- and Other Voice-dependent Professionals -
Helps Maintain Proper Nasal Health

PHOENIX, Matrixx Initiatives, today
announced that its Nasal Comfort(R) Moisture Therapy, 100 percent pure,
sterile and preservative-free hypertonic mist, will be part of the 48th Annual
GRAMMY Awards gift basket that will be distributed to the show 's presenters
and performers. Nasal cleansing is an age-old practice
that, in many parts of the world, is as commonplace as the Western practice of
brushing one's teeth. Take a
long, hot shower or apply a warm washcloth to your face. Its unique formulation and patented
Micro-filtration Sprayer ensure the product remains sterile and because it's
preservative-free and drug-free it's non-habit forming, safe to use with all
medications and can be used as often as needed.

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Regeneron Pharmaceuticals to Present Data from VEGF Trap and IL-1 Trap Studies

Presentations will include data in eye diseases, oncology and
inflammatory diseases.99.

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Many doctors recommend nasal irrigation with a hypertonic
saline mist as a way to relieve congestion, make breathing easier and promote
proper nasal health for vocalists and other professionals who depend on their
voice for their livelihood .
Nasal Comfort is available at fine stores nationwide at a suggested retail
price of $15.

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Y ." This trial was conducted under
Regeneron's collaboration agreement with the sanofi-aventis Group for
eye diseases through systemic delivery systems, such as intravenous
infusions.m.
"We live in a world full of ever increasing environmental contaminants and
other natural irritants that cause a variety of respiratory diseases such as
chronic sinusitis, allergic rhinitis, and asthma .

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At the 2005 American Society of Oncology (ASCO) Annual Meeting
taking place in Orlando, FL from May 13-17, Dr. Zicam, LLC, its wholly-owned subsidiary, produces, markets
and sells Zicam(R) products in the cough and cold category; and recently
launched a new brand, Nasal Comfort(TM), for nasal health .