"

About the Problem (Benign Prostate Hyperplasia - Enlarged Prostate)

Virtually every other man over the age of 50 will over time be affected by
urination problems due to benign prostate hyperplasia, BPH. These
minimally invasive methods involve the use of microwave thermotherapy to
reduce the size of the prostate. No
other minimally invasive, microwave thermotherapy devices have these
capabilities.

An observational study published in the May 2005 issue of The Journal of
Sexual Medicine found that patient-reported outcome measures (PROs), such as
control over ejaculation, satisfaction with sexual intercourse and distress
are important factors in assessing the benefit of treatments for PE in
clinical studies.

*Intravaginal Ejaculatory Latency Time (IELT) - IELT was first introduced
in 1994.

disorder webmd

Unlike Johnson and Johnson's Dapoxetine, an oral
treatment under development, NM100061 is applied locally.

Dr.

In the past few years , a new type of minimally invasive methods to treat
BPH have become the treatment of choice for more and more patients.
Prostalund has approximately forty employees in Sweden, a subsidiary in
Germany , and sales and distribution organizations throughout Europe, the
Middle East, China and the rest of the world. Patients were asked to take study medication one-to-three hours
before intercourse .

-- The percentage of men rating control over ejaculation as "fair to very
good " increased dramatically for dapoxetine 30 mg (2.

-- The percentage of men rating sexual satisfaction as "good to very good"
almost doubled with dapoxetine 30 mg (20. It can affect his and his partner's sexual
satisfaction and their ability to build and maintain relationships -- both
sexual and non-sexual - and can impact a man's general sense of self-
confidence., has a proven
track record of leadership in the field of urology and is committed to
providing patients with products that help them live healthier lives and
improve their quality of life.

cope depth

Participants had IELT of two minutes or less in at least
75% of intercourse episodes occurring during the two-week baseline run-in
period prior to treatment.4%) compared to placebo (3.6% to 24. The most common adverse
events reported with both 30 mg and 60 mg doses of dapoxetine were nausea,
followed by headache.

infocenter causes

S. Prostalund is the developer and manufacturer of
the unique and patented CoreTherm medical device for treatment of benign
prostatic hyperplasia, based on a unique customized microwave treatment
that takes place while monitoring the temperature of the prostate.
The results showed:

-- Men taking dapoxetine 30 mg and 60 mg experienced more than a three-to-
four fold increase in mean IELT compared with placebo (P-value <0.6%).2%).

incidence resolve

Addressing a patient's BPH
problem often becomes a choice between surgery, a minimally invasive
procedure or symptom-controlling medication. The company's operations are
carried out in close collaboration with leading universities and hospitals
in Sweden, the U.

The study also found that dapoxetine was generally well tolerated, with
most side effects of mild-to-moderate severity.

premature incidence

Prostalund AB, a Swedish developer and
manufacturer of medical devices, today announced the opening of Prostalund,
Inc.
ProstaLund is the developer of CoreTherm , a unique medical device that
utilizes minimally invasive, microwave thermotherapy to treat an enlarged
prostate (BHP - benign prostatic hyperplasia), which affects millions of
men in the U. "Our new Los Angeles office will allow
us to fully develop the U. Prostalund's CoreTherm method utilizes
its own innovative technologies to provide temperature feedback and control
during the procedure in order to produce better results. Pryor, M.

factors ejaculation

and Canadian markets.

Adjustable Microwave Power /Temperature Control: CoreTherm allows the
physician to precisely adjust the temperature to treat each individual
patient's condition.
According to the American Urological Association, premature ejaculation
may be the most common male sexual disorder.3%
to 46.

Premature ejaculation is a common problem among men.

afflicted bearing

NexMed, Inc. Gittelman's four presentations are titled:


-- Synergistic effect of meatal application of dyclonine/alprostadil
cream for the treatment of Early Ejaculation ("EE") in a double-blind and
crossover study

-- The use of the female sexual function index to assess the efficacies
of an alprostadil cream in a placebo-controlled , double-blind study in
patients with female sexual arousal disorder

-- A placebo-controlled , double-blind study of the efficacy and safety of
an alprostadil topical cream in patients with female sexual arousal
disorder

-- Effects of an alprostadil cream on sexual arousal response in
premenopausal women with female sexual arousal disorder


Copies of the abstracts are available through NexMed. The
Company is also working with various pharmaceutical companies to explore
the incorporation of NexACT into their existing drugs as a means of
developing new patient-friendly transdermal products and extending patent
lifespans and brand equity.S.
"The impact premature ejaculation can have on men and their partners can
be devastating for a relationship and, currently, there are no truly optimal
therapies for PE," says Jon L.7%) and 60 mg (22. The study found that men with PE and their partners
reported higher ratings for interpersonal difficulty , lack of control over
ejaculation and dissatisfaction with sexual intercourse. The amount
of time this process takes is known as intravaginal ejaculatory latency time
or IELT.

expectations premature

There are
meaningful improvements in this study across all primary and secondary
endpoints, including a three-to-four fold increase in IELT. Most physicians do not screen for
PE and patients are extremely reluctant to talk about the condition with their
partners or health care professionals.

afflicted disorder

Dr., based in Los Angeles, is a wholly owned subsidiary of
Prostalund AB in Sweden.

First Medication Developed To Treat Premature Ejaculation Demonstrates Improvement In Control Satisfaction And Time

, chairman and program director of
the Department of Urologic Surgery at the University of Minnesota and lead
investigator of the dapoxetine phase III clinical trials.

considered participation

IELT increased significantly with the first dose
of dapoxetine, and increases in IELT were maintained over the 12-week
study period.

webmd participation

It is now available to hospitals,
clinics, and physicians in the U.

The
U. PE can have a significant impact on
many aspects of a man's life.

** Represents Hispanic, Caucasian , and African American men.

caused disorder

, a wholly owned subsidiary based in Los Angeles, California. Without this
monitoring, patients are frequently (up to 40%) under treated, which leads
to less than optimal results or even the need to be treated again in the
future.coretherm.D. A stopwatch may be operated by either partner and is activated
when the male enters the female and stopped when a man ejaculates .

condition disorder

PRESS RELEASE New CoreTherm Medical Device Treats Enlarged Prostates Faster With Optimum Results

(Click here for details)
"We believe CoreTherm offers the best treatment option for the millions of
men with moderate to severe symptoms of BHP," stated Magnus Bolmsj,
founder and CEO of ProstaLund AB.

Best Results: CoreTherm is the only minimally invasive microwave
thermotherapy device that consistently reduces patient symptoms from severe
to mild."

Phase III Trial Design and Results
The phase III clinical trials studied 2,614 men with PE aged 18-77 in
monogamous sexual relationships of greater than six months.

Contacts:
Peggy Ballman Effie Delimarkos
Ortho Urology Ortho Urology
Cell: 908/310-7721 Cell: 908/675-0152
Office: 908/927-3629 Office: 908/218-7542

bearing fiore

This control is important because it reduces the
chances the prostate is either over treated or under treated . "The results with
dapoxetine are compelling.5% to 51.2% to 38.

resolve completion

S.Phase III Clinical Trial Results for Dapoxetine Hydrochloride Offers Hope for
Men Suffering from a Common Male Sexual Dysfunction

SAN ANTONIO, Data presented today demonstrates that
men taking dapoxetine hydrochloride for the treatment of premature ejaculation
(PE) experienced significant improvements in sexual function, including
ejaculatory control, satisfaction with sexual intercourse for men and their
partners, and increases in intravaginal ejaculatory latency time (IELT)*. PE can be a lifelong condition experienced from the
beginning of sexual activity or can develop after years of satisfactory sexual
activity.

By definition, ejaculation of the male prior to completion of the sexual act is considered premature ejaculation.

fiore depth

PRESS RELEASE NexMed Presents New Data at ESSM Including Data on Early Ejaculation Product

EE, commonly known as premature ejaculation, is the most prevalent male
sexual dysfunction, affecting as many as one-third of men worldwide at some
time in their lives. is an emerging drug developer that is leveraging its
proprietary drug technology to develop a significant pipeline of innovative
pharmaceutical products to address significant unmet medical needs. It is estimated that PE may
affect 27% to 34% of men across all age ranges**, in contrast to erectile
dysfunction, which is estimated to affect 10% to 12% of all men, who are
usually older in age.4%).

-- The percentage of partners rating sexual satisfaction as "good to very
good" almost doubled with dapoxetine 30 mg (20.

About Premature Ejaculation (PE)
Although PE is one of the most common male sexual disorders, it remains
widely under-diagnosed and under-treated.

definition factors

This condition
causes troublesome symptoms and anxiety that adversely affects quality of
life for millions of men around the world.

Accurate Monitoring of Intraprostatic Temperature: By accurately monitoring
the temperature of the prostate during the procedure, physicians can see
the real-time effects of the treatment in progress.

Fastest Treatment Time: CoreTherm treats patients in 10-15 minutes, while
other microwave thermotherapy devices require 30-60 minutes of treatment.com. Food and Drug Administration is currently reviewing a New Drug
Application for dapoxetine, which if approved, would be the first prescription
product indicated for the treatment of PE.
Men in the studies were randomized to receive 30 mg or 60 mg of dapoxetine
over 12 weeks in two identical, double-blind, placebo-controlled, multicenter
trials.
The studies examined changes from baseline for mean IELT as monitored by a
stopwatch; measured the subject's ejaculatory control and sexual satisfaction
on a five-point scale from "very poor to very good"; and measured the
partner's satisfaction with sexual intercourse from "very poor to very good".5% to 26.

prior premature

NexMed, Inc.

CoreTherm received FDA approval in 2003 and has successfully treated
approximately 15,000 patients worldwide.

webmd depth

These data were presented at the
100th Annual Scientific Meeting of the American Urological Association. The unique profile of dapoxetine translated
into targeted treatment of PE compared to existing therapies.8%) and
60 mg (3.1% to 25.

expectations premature

Patients greatly appreciate this benefit.

About Prostalund

ProstaLund, Inc.S.4% to 39%) and 60 mg
(24.

participation bearing

Marc Gittelman, MD, FACS, Director of the Miami
Center for Sexual Health and a NexMed consultant, will make four
presentations at the 8th Annual Meeting of the European Society for Sexual
Medicine ("ESSM"), which takes place December 4-7, 2005 in Copenhagen,
Denmark.

About NexMed, Inc.

market and support physicians and healthcare
organizations with a product designed to improve patients' lives and well
being.S.5%), respectively, in comparison to placebo (21.4%), respectively, compared to placebo (20.

definition tcm

, and around the world. PE was defined as
persistent or recurrent ejaculation sooner than desired either before or
shortly after penetration, typically reflecting an IELT of two minutes or
less, over which the sufferer has minimal or no control.8% to 47. It is used in clinical setting involving the study of premature
ejaculation.

disorder condition

Gittelman's presentations will include data on NM100061,
NexMed's proprietary early ejaculation ("EE") treatment under development . Other minimally invasive procedures only reduce the symptoms from
severe to moderate. at (310) 559-6015 or visit their Web site at
www. They demonstrate that, for the first time, a
medicine can be taken by men on an on-demand basis and provide significant
improvement in their PE condition .0001
at 30 mg and 60 mg). Ortho Urology has a history of clinical
expertise and is committed to bringing patients the most advanced options in
urology with products such as ELMIRON(R) and DITROPAN XL(R).

ejaculation expectations

(NASDAQ: NEXM), a developer
of innovative treatments based on the NexACT drug delivery technology ,
today announced that Dr. CoreTherm, administered on an outpatient basis, provides
the fastest treatment for patients, produces results equivalent to surgery,
and has lower costs than surgery or drug therapy.

About CoreTherm

CoreTherm's unique features and patented design make it the most advanced
minimally invasive procedure available today for the treatment of BHP.

For more information including clinical findings, sales, and distribution,
contact Prostalund, Inc.3 % to 58.

About Ortho Urology
Ortho Urology, a unit of Ortho-McNeil Pharmaceutical, Inc.

Age has no bearing upon the individual afflicted with the disorder.

condition fiore

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