Since its approval in 1997, SEROQUEL has had over 8 million
patient exposures worldwide.D."
These goals, are ambitious but can be accomplished if
geriatricians are able to productively partner with other physicians,
health care professionals, consumer groups, and lawmakers, Dr.

expectancy geriatric

D.

Business Editors

NEW YORK----

American Geriatric Society Leading the
Charge to Optimize Care of Older Americans

A proactive new study released yesterday by the American
Geriatrics Society (AGS) concludes that the current shortage of
geriatricians and health care professionals trained to care for older
Americans could reach crisis proportions in the next 25 years as
millions of Baby Boomers hit retirement age.americangeriatrics .

dementia felician

IMPORTANT SAFETY INFORMATION ABOUT SEROQUEL
Prescribing should be consistent with the need to minimize the risk of
tardive dyskinesia.

Reuben
adds.

aging healthandage

Hyperglycemia , in some cases extreme and associated with ketoacidosis,
hyperosmolar coma or death, has been reported in patients treated with
atypical antipsychotics, including SEROQUEL.
"We coordinate care with other professions and across
community-based settings to ensure that patients' needs, as well as
those of patients' caregivers, are met," explains David B. With an active membership of over 6,700 health care
professionals, the Society has become a pivotal force in shaping
attitudes, policies and practices in geriatric medicine.

Geriatric Medicine is a branch of general medicine concerned with the clinical, preventive, remedial and social aspects of illness in older people.

uk/

caregiving autonomy

D.9%) group, and
four in the placebo group (1. As this report attests, AGS
members are working to implement change and incentives to attract more
physicians to this field to ensure that we can provide appropriate
care for the rapidly growing aging population. "Yet if our society is to meet the health
care needs of older persons, we must face these challenges and
succeed.

gerontology disclaimer

Results from the study were initially presented at the 9th International
Conference on Alzheimer's Disease and Related Disorders in Philadelphia in
July 2004.
Precautions include the risk of seizures, orthostatic hypotension and
cataract development. It is one of the
world's leading pharmaceutical companies with healthcare sales of over
$21. Reuben,
M., President of the Society. Our nation's older people deserve nothing less."

ABOUT AGS

The Future of Geriatric Medicine report can be accessed for free
at http://www.

bgs.

brookdale carer

The most commonly observed adverse events associated with the use of
SEROQUEL in clinical trials were somnolence, dry mouth, dizziness,
constipation, asthenia, abdominal pain , postural hypotension, pharyngitis,
SGPT increase, dyspepsia and weight gain.

autonomy gerontologists

These include the following:

Ensure that every older person receives high-quality,
patient-centered health care;

Teach health care professionals in other fields how to better
meet the unique health care needs of older adults so they can
employ the principles of geriatric medicine in caring for
older persons;

Recruit physicians and other health care professionals into
careers in geriatric medicine;

Unite professional and lay groups in the effort to influence
public policy, including Medicare policy, to continually
improve the health and health care of seniors.

geriatric caregiving

4 billion and leading positions in sales of gastrointestinal,
cardiovascular , respiratory, oncology and neuroscience products. In the
United States, AstraZeneca is a $9. American Academy for
Geriatric Psychiatry annual meeting, March 2005.
Thanks to the graying of the Baby Boom generation, the number of
adults 65 and older will double over the next 25 years, topping 71. "Geriatricians understand the need to
work collaboratively with other professional disciplines to improve
the health, functioning, and well-being of older persons and to help
them maintain an independent lifestyle.

physiological ageing

These results suggest that SEROQUEL did not
increase the risk of CVAEs in this group of patients. Only 62 physician-fellows were in their second or subsequent
years of training in geriatric research - nationwide - in 2003.

fellowships uams

AstraZeneca is listed in the Dow Jones Sustainability
Index (Global) as well as the FTSE4Good Index.5
million.D.

bgs fellowships

CVAEs are a side effect
that have been associated with the use of some other atypical antipsychotics
in this population. SEROQUEL is currently approved for the treatment of schizophrenia
and the treatment of acute manic episodes associated with bipolar I disorder.
SEROQUEL is not approved for treatment of patients with dementia-related
psychosis.seroquel.

gerontologists carer

, professor of psychiatry, neurology, and gerontology, at the
University of Southern California.9%). Patients starting treatment with
atypical antipsychotics who have or are at risk for diabetes should undergo
fasting blood glucose testing at the beginning of and during treatment.

carer ageing

, Data presented today
at the annual meeting of the American Association of Geriatric Psychiatry
(AAGP) include results from a pooled analysis of two 10-week placebo-
controlled trials that examined SEROQUEL(R) (quetiapine fumarate) in elderly
patients with dementia. Schneider, M.
In The Future of Geriatric Medicine, the AGS identifies current
obstacles for geriatricians and caregivers , and outlines strategies to
overcome them, making recommendations to optimize the health of older
persons over the coming decades.org/news/AM051205.pdf.

bgs felician

astrazeneca-us.

(1) Schneider L , Cerebrovascular Adverse Events and Quetiapine: A Pooled
Analysis in Elderly Patients with Dementia. "Geriatricians take care of people,
not just their diseases.

"In the coming years , geriatricians will be key leaders of change
to achieve the goals of improving and maintaining a healthy senior
population," says Meghan Gerety, M..

geriatric brookdale

CVAE Analysis
In the results from the safety analysis of CVAEs (mainly stroke and
transient ischemic attacks), in the two 10-week , double-blind placebo-
controlled trials, a total of 684 patients (mean age 83 years; 80% with
Alzheimer 's disease, 14% with vascular dementia, and 6% with other dementia
types) were randomized to receive SEROQUEL, haloperidol or placebo.
For full prescribing information for SEROQUEL, please visit the website
http://www.

ABOUT ASTRAZENECA (NYSE: AZN)
AstraZeneca is a major international healthcare business engaged in the
research, development, manufacture and marketing of prescription
pharmaceuticals and the supply of healthcare services.

Lack of Physicians to Care for Growing Senior Population Spurs Call for Redesign of Health Care System

sticht felician

Study Examines SEROQUEL and the Risk of Cerebrovascular Adverse Events in Elderly Patients with Dementia

The results of a safety analysis , which was performed
as a secondary endpoint and assessed the risk of cerebrovascular adverse
events (CVAEs) in elderly patients taking SEROQUEL, were presented by Lon S.8%) group, one in the haloperidol (0.
Patients who develop symptoms of hyperglycemia should also undergo fasting
blood glucose testing .

expectancy psychosocial

- Results suggest that SEROQUEL did not increase the risk of CVAEs -

WILMINGTON, Del . The Society supports this mission through activities in
clinical practice, professional and public education, research and
public policy.

geriatrics gerontology

Patients should be periodically reassessed to determine the need for continued
treatment.com.
According to the report, Caring for Older Americans: The Future of
Geriatric Medicine, by 2030, there will be only one geriatrician for
every 7,665 older adults - unless major steps are taken to recruit and
train geriatricians.
A key component of geriatric medicine is the management of chronic
conditions, often multiple and usually incurable, in a variety of
settings, including home, nursing homes, and community-based long-term
care sites.

residencies sticht

The
numbers of patients who experienced CVAEs in this pooled data analysis were
three in the SEROQUEL (0.

healthandage autonomy

Schneider , M.6 billion healthcare business with more
than 12,000 employees. But despite growing demand, a declining number of medical
students are currently choosing to specialize in geriatrics (current
Medicare reimbursement policies are one, but not the only,
disincentive).

- British Geriatrics Society - http://www.

aging uams

felician psychosocial

(1A)
"These results are potentially significant for the dementia population ,
but suggest that quetiapine be further investigated in clinical trials to
assess safety and effectiveness ," said Lon S.
For more information about AstraZeneca, please visit:
http://www. And
funding for research on aging has been inadequate. Founded in
1942, the American Geriatrics Society is a nationwide, not-for-profit
association of geriatrics health care professionals dedicated to
improving the health, independence and quality of life of all older
people.

brookdale ahrq

(1B) The CVAE analysis showed that SEROQUEL
was not significantly different than placebo.com."
The report - the work of an AGS task force that included more than
two dozen leading geriatrics practitioners, researchers, and academics
- also documents the need for a greater commitment to geriatrics
research., chair of the board of the
American Geriatrics Society.

org.

caregiver nejm

, professor of
psychiatry, neurology, and gerontology, at the University of Southern
California. A rare condition referred to as neuroleptic malignant
syndrome has been reported with this class of medications, including SEROQUEL.
"The agenda is broad, the need is dire and the obstacles are
immense," he continues.