Tsuda, Chairman of the Host Organizing
Committee of the Kyoto Conference: "Historically, diagnosis and treatment
recommendations written by specialists without input from primary care were
not always applicable in real life in a busy practice. In addition to supporting IPAG, Wonca will
also be one of the leaders of the Global Alliance against Respiratory Disease
(GARD) - a global initiative spearheaded by the World Health Organization
(WHO).

For more information about BIO CEO visit
http://ceo.

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* COPD ranks number three (3) in acute hospital admissions among
Medicare aged people.

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Says Prof.com

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S.

About NECA:
NECA is a non -profit, patient-centered, member-driven, and member-
governed organization.org
or call 1-866-229 -2768.org
World Organization of Family Doctors http://www.

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Organization to Help Thousands of People in Colorado

DENVER, The National Emphysema/COPD Association
(NECA) announced today the launch of NECA Colorado Network. A simple lung
function or spirometry test that takes less than a minute can reveal pulmonary
obstruction and the presence of emphysema/COPD. (behind heart
disease, cancer, and cerebrovascular disease). Our mission is to empower people with emphysema /COPD
and their families and caregivers to improve the quality of patient care and
the quality of their lives.

The "IPAG Handbook" has been
developed by a joint task force of primary care physicians and respiratory
specialists to improve global care of three leading chronic respiratory
diseases - asthma, COPD, and allergic rhinitis.

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Approximately half of COPD
patients are correctly diagnosed. T.

About TOPIGEN

TOPIGEN is a privately held biopharmaceutical company focused on developing
new classes of inhaled drugs for respiratory disorders. By
topically targeting multiple affected airway receptors with its drugs, the
Company expects to improve outcomes for many patients with respiratory
diseases.

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NECA Colorado
will focus its efforts on helping educate and support the nearly 200,000
people diagnosed with COPD (Chronic Obstructive Pulmonary Disease) in the
state as well as their families. Management recommendations of IPAG are in conformity with GINA, GOLD
and ARIA.

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NECA holds regular educational seminars to help patients better understand
their conditions and treatment options and inform them on the latest research
and information. Differential
diagnosis between COPD and asthma is of essential importance as the two
diseases may require different approaches to treatment.

PRESS RELEASE TOPIGEN's CEO to Present at BIO CEO +amp; Investor Conference

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The Colorado organization places emphasis on patient self-care and peer
support.
Chronic obstructive pulmonary disease (COPD), asthma, and allergic
rhinitis are the most common chronic respiratory diseases worldwide, but are
significantly under-diagnosed in primary care. The IPAG expert panel included the world's
leading primary care physicians as well as the specialist representatives of
GINA , GOLD and ARIA.whiar.

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S. Wotton is presenting on Wednesday, February 15th, at 11:30 AM
in the Park Avenue Suite Center/North and will be available for one-on-one
meetings during the conference.com .

TOPIGEN is a leading biopharmaceutical respiratory company with two drugs
undergoing Phase II clinical trials for the treatment of COPD (TPI-1020)
and asthma (TPI-ASM8).

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It is believed that the numbers of COPD patients in the state that are
undiagnosed could double the number of cases . These guidelines, developed by
panels of leading experts, include the latest evidence available on diagnosis
and treatment and are now the most referenced resources of information on
asthma , COPD and allergic rhinitis, respectively.A.com.

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S.

* Economic costs in the U. A special questionnaire module
has been developed to support the differential diagnosis between COPD and
asthma .bio.

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It is COPD focused and was created for and about COPD patients. as well, and is projected to move to third place by 2020.

Wonca Emphasizes the Central Global Role of Family Doctors Caring for Patients With Respiratory Diseases

org
Allergic Rhinitis and its Impact on Asthma http://www. Paul Wotton, President and Chief
Executive Officer, will be presenting at the 8th Annual BIO CEO & Investor
Conference in New York City (February 14-15, 2006), at the Waldorf Astoria
Hotel.

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There are also about 222,000
people with adult asthma; a significant number of these asthmatics already
have or eventually will develop COPD and emphysema.

* COPD is responsible for 3 million physician visits and 1. COPD is the leading cause of
smoking-related disability, more than stroke and heart disease. Their usability in primary
care, however, has been limited until now, as the guidelines were not
specifically designed for operational use in primary care settings.
Notes to Editors:

Additional information:
IPAG Handbook http://www.org
Global Initiative for Chronic Obstructive Lung Disease http://www.goldcopd. The presentation will include an update of the
company's progress on the two programs.

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, University of Colorado Health Sciences Center.
According to the NIH National Heart, Lung, and Blood Institute, COPD was
the fourth leading cause of death worldwide in 2000.5 emergency
room visits each year. related to COPD top an estimated
$32 Billion. New tools for diagnosis have
been developed for primary care settings and are provided with management
recommendations based on latest available evidence.com
Global Initiative for Asthma http://www. Wotton's presentation will be webcast and available, both live and for
replay , via the Company's website at www.

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D."
The expert panel developed and validated a set of questionnaire tools to
help busy primary care physicians attribute the patient's presenting symptoms
to either asthma, COPD or allergic rhinitis.

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For more information, visit http://www., for COPD and other respiratory diseases
with an option for worldwide rights.

Respiratory conditions include disorders that affect the lungs.

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Included in the definition of
COPD is chronic bronchitis that affects about 127,100 people in the state, as
well as emphysema that affects more than 40,000.
"We are pleased to launch this statewide organization in Colorado. The Company's Phase II
products and research programs are uniquely focused on inhibiting multiple
inflammatory pathways at the cellular site of lung inflammation .

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National Emphysema/COPD Association Launches Colorado Network

With
the numbers of Coloradoans affected by lung disease, there is a tremendous
need for education, support and resources.
"Patients in Colorado are hungry for an organization like NECA. It ranks fourth in the
U. KYOTO , Japan,
- Wonca Announces Release of International Primary Care Airways Group
(IPAG) Report Providing New Approaches to Facilitate the Diagnosis and
Management of Asthma, COPD and Allergic Rhinitis in Primary Care Settings
The first report of International Primary Care Airways Group (IPAG) has
been launched today during the Asia Pacific Regional Conference of the World
Organization of Family Doctors (Wonca).
TOPIGEN Pharmaceuticals Inc. This pioneering approach has shown promising preclinical and
clinical results in inhibiting the underlying inflammation associated with
many pulmonary conditions such as asthma, COPD and allergic rhinitis.org/opencms/ceo/2006/index.

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NECA Colorado will also seek to
increase public awareness about the disease.necacommunity.globalfamilydoctor . In October 2005, TOPIGEN in-licensed North American rights
for the compound from NicOx S.jsp

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Though the disease is chronic, early detection allows the
opportunity for early intervention , which provides a better and more
functional quality of life for people with the disease. There are
also many misconceptions out there about COPD and NECA will be instrumental in
providing accurate information and increasing awareness about the disease,"
said Tom Petty, M.

* COPD is the fourth leading cause of death in the U.

The 8th Annual BIO CEO & Investor Conference, one of the year's largest
life science investor events, provides a forum for private and public
companies to present progress on their development programs with investors
and the financial community.

TPI-1020 is a novel, proprietary nitric-oxide donating derivative of
budesonide. TOPIGEN's pipeline
includes small molecule and RNA-based therapeutics.

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NECA provides these COPD statistics:

* More than 15 million people in the United States have been diagnosed
with COPD and another 15 million are thought to have it and are
undiagnosed. These were the Global Initiative for Asthma (GINA) in 1997, the
Global Initiative for Obstructive Lung Disease (GOLD) and Allergic Rhinitis
and Its Impact on Asthma (ARIA) in 2001.
Wonca will take an active part in the dissemination and implementation of
IPAG through its 100 member organizations, which represent more than 150,000
family doctors around the world.

Dr.
This pioneering approach addresses the issue of pathway redundancy by
blocking the expression of specific genes in multiple pathways responsible
for asthma and allergic inflammation.

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We are here to give patients and
their families information they can trust," said Brenda Crowe, local
coordinator of NECA Colorado.
Global guidelines on the three chronic diseases have been introduced in
recent years.
The IPAG task force was established in 2002 to develop evidence-based
guidelines specifically designed for use in primary care settings, on the
basis of GINA, GOLD and ARIA. IPAG is an important
step in growing cooperation between secondary and primary care towards
improving standards of care for chronic respiratory diseases.ginasthma.globalfamilydoctor., a
biopharmaceutical company specializing in innovative respiratory
therapeutics, today announced that Dr. Dr.topigen. TOPIGEN screened, evaluated and validated this small molecule
using the company's discovery expertise and demonstrated novel activity in
models of COPD.

TPI-ASM8 is a first-in-class, inhaled drug that combines two
oligonucleotides into a single product delivered directly to the lungs for
knock-down of cell receptors involved in the development of chronic asthma. For
more detailed information on TOPIGEN visit www.topigen.

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