,
today announced that data from a study conducted
with a Multiple Sclerosis
(MS) animal model demonstrated that Symadex(TM) permitted remyelination
by
prevention of inflammatory cell infiltration., a
platform-based drug development and advanced
medical diagnostics company,
today announced that the National Institute of Neurological Disorders
and
Stroke (NINDS) branch of the National Institutes of Health (NIH) has awarded
the Company a
Phase I Small Business Innovation Research (SBIR) grant to
develop applications of a KineMarker
(TM) assay for myelin disorders. MS is the most common of the demyelinating diseases and is a chronic
,
progressive neurologic disorder that affects 250,000 - 300,000 people in the
United States.
KineMed not only provides an ability to screen for best in
class of a formulation, but enables the
discovery of entire new therapeutic
applications for existing compounds.
marylanders togetherness
This platform technology
measures the dynamics of therapeutic
response to drugs in the intact organism, both animal and human
.marylanders webpalette
mccarthy@xanthus.KineMed Announces Award of SBIR Phase I Grant for Program in Neurobiology
tameside clams
stevenage infoscience
5
million
people worldwide.xanthus. The
Company's KineMarkers (TM) are in vivo, stable isotope kinetic biomarkers
that
measure the flux of molecules through complex and therapeutically relevant
biological pathways
. The potential to add value through repurposing is therefore
significant.attacked merle
About Xanthus
Life Sciences, Inc.
Many sites provide up to the minute news on issues related to health.
herts summerville
There
are a number of important factors
that could cause Xanthus' actual results to differ materially from
those
indicated by such forward-looking statements, including risks as to whether
results obtained
in early clinical studies or in preclinical studies such as
the studies referred to above will be
indicative of results obtained in future
clinical trials or warrant additional trials; whether products
based on
Xanthus' technology will advance through the clinical trial process and
receive approval
from the United States Food and Drug Administration or
equivalent foreign regulatory agencies; whether
the company will have the cash
resources to develop and commercialize its products; and whether the
patent
and patent applications owned or licensed by Xanthus will protect the
Company's technology
and prevent others from infringing it. -
kwatson@macbiocom., Senior Vice President + CFO, Xanthus
Life Sciences,
Inc. The success of receiving initial and
ongoing grant funding could differ
materially from expectations projected in
the forward-looking statements as a result of known and
unknown risk factors
and uncertainties.summerville orland
, Xanthus Life Sciences, Inc. Symadex was found to produce
remyelination in the study even after 40 days of inflammatory insult by
preventing the infiltration
of autoreactive cells into the central nervous
system. MS symptoms may include vision problems, loss
of balance,
numbness, difficulty walking and even complete paralysis. Although KineMed's
technology
is applicable to developing new chemical entities, KineMed is a
"repurposer" of drugs.webpalette herts
Stephen J
.
Dr.
About Symadex(TM)
Symadex (formerly C-1311) is a next-generation investigational
drug that
has shown a potentially novel, targeted mechanism of action in studies of
cancer and
autoimmune disease.com. Without limiting the foregoing, the
words, "believes," "anticipates," "plans
," "expects," "estimates," "intends,"
"should," "could," "will," "may," and similar expressions are
intended to
identify forward-looking statements. Current
treatment strategies for MS have largely
been aimed at the presumed
immune-mediated aspect of the disease.togetherness sclerosis
Symadex was developed to deliver
efficacy
comparable to the anthracenediones (e.g., Novantrone(R) (mitoxantrone)), but
with a molecular
scaffold intended to reduce the cardio- and hemato-toxicities
known to be associated with these active
drugs. Additionally, in previous
preclinical studies, Symadex has shown early evidence of both oral
activity
and efficacy in various models of acquired drug resistance and autoimmune
disease. Pathologically
, MS is characterized by the presence of areas
of demyelination and T-cell predominant perivascular
inflammation in the brain
white matter.
This press release contains "forward-looking" statements
within the
meaning of Section 21A of the Securities Act of 1933, as amended, and Section
21E of
the Securities Exchange Act of 1934, as amended, and is subject to the
safe harbors created thereby
.chatter merle
- john. As part of KineMed's neurobiology initiative, KineMed
researchers have developed a biomarker
that measures the synthesis of myelin,
the outer covering of nerve cells that is destroyed in Multiple
Sclerosis and
other neurodegenerative diseases. Every major pharmaceutical firm has a group of
such
compounds.Sites in this category serve the support needs of people with Multiple Sclerosis or similar
conditions.
Many sites listed are interactive - you will find message boards
webforum musketeers
Karlik is widely recognized
for investigating potential new therapies
for MS in a specialized animal model of human MS that incorporates
both
inflammatory and demyelinating properties. The Company is
applying its expertise both to
advance its current pipeline and expand it into
indications of unmet medical need beyond oncology
.
Contacts:
Kari Watson, MacDougall Biomedical Communications, Inc.
glossop orland
com
or (508) 647-0209
John A.validated merle
merle mss
It is a disease typically of young adults, mostly
women, with
onset typically between 20 and 50 years of age. Each hour someone
is newly diagnosed.orland infoscience
- Results
Presented at the International Workshop on Myelin Imaging in
Vancouver
-
CAMBRIDGE, Mass. The Company is conducting Phase 2 clinical trials with Symadex in
several
tumor indications and is also exploring the use of Symadex for the
treatment of a number of autoimmune
diseases, such as Multiple Sclerosis.
This press release contains forward-looking statements
concerning Xanthus
that involve a number of risks and uncertainties. This new
grant is in addition
to over $5 million dollars previously awarded in the
areas of prostate cancer, osteoarthritis, toxicology
, and chronic lymphocytic
leukemia. delivers new, significant value from existing drugs using
its
proprietary, kinetic biomarkers. Many efforts to breathe new life into existing drugs focus on
approaches
such as reformulations, which can indeed yield meaningful
improvements.literate marylanders
D. Boss, PhD.
Xanthus
is headquartered in Cambridge, Massachusetts with an additional
facility in Montreal, Quebec.
Associated with significant disability, MS has a large impact not only on
health but also on quality
of life, productivity and employment.
About KineMed, Inc.sclerosis clams
Karlik.
About Multiple
Sclerosis
Multiple Sclerosis (MS) is a chronic, unpredictable disease of the central
nervous
system that, according to the National MS Society, affects
approximately 400,000 people in the United
States and approximately 2. "KineMed's proprietary assay technologies reveal new understandings
of
pathogenesis, and we look forward to developing both a preclinical and
clinical kinetic biomarker
test in Multiple Sclerosis and other disorders of
demyelination which may enhance the efficiency
of drug development and also
guide clinical decision making and alternate treatment strategies.
About KineMarker(TM) Assays
Kinetic biomarkers, or KineMarkers(TM), provide an exclusive
set of tools
for measuring the flux of molecules through complex biomolecular pathways in
living
systems.demyelinating ms
Treatment proved to be effective in both the acute and chronic
presentations of disease
. For this purpose, any
statements contained herein that are not statements of historical fact may
be
deemed to be forward-looking statements. This is done quickly and cost-effectively, both in animal
models and in human subjects, producing new insights into the therapeutic and
economic potential
of a company's existing compounds.
The sites provide information and resources.
attacked summerville
"Symadex
is now in Phase 2 trials in oncology and the positive results of
this animal model study show the
candidate's potential for treating MS and
provide the support needed to advance Symadex towards human
trials for MS,"
said Michael A. is developing a portfolio of novel, clinical-
stage, small-molecule
oncology drugs through a management team whose
accomplished track record encompasses all aspects
of drug development, from
discovery through regulatory approval and commercialization.attacked herts
Karlik, Ph
. Chief Business Officer at Xanthus. McCarthy, Jr.herts chatter
,
Professor of Diagnostic Radiology at the University
of Western Ontario,
London, Ontario presented the research findings on February 10, 2006 at the
International
Workshop on Myelin Imaging, in Vancouver.
"The early results from this study showed that the
animals in the study,
which were paralyzed due to neurological impairment, were able to recover
and
regain their mobility after treatment with Symadex," commented Dr. Xanthus disclaims
any
intention or obligation to update any forward-looking statements.
KineMed, Inc.stevenage musketeers
Xanthus' Symadex
(TM) shows Remyelination in Multiple Sclerosis Animal Model
Xanthus Life Sciences, Inc.,
KineMed, Inc.
"The NIH has again chosen to provide funding for KineMed to develop a test
in
yet another disease state," commented David Fineman, President and CEO of
KineMed. KineMed's patented
approach merges the
insights and methods of systems biology with the precision and specificity of
molecular analysis. Such forward-looking statements include
statements regarding KineMed's expectations
in receiving grant funding in the
amount and on the schedule noted above.tameside caithness
More information is available
at http://www. - KineMed to Develop Clinical Assay for Multiple Sclerosis, Other
Myelin Disorders -
EMERYVILLE, Calif."
About Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic disease of the central nervous
system, which predominantly
affects young adults during their most productive
years. KineMed's technologies apply towards discovering
new
uses for both approved and unapproved compounds that have clinical data and
favorable safety
profiles. Such factors may include, but are not limited to, risks
and uncertainties related to how
KineMed's research initiatives progress and
meet expectations over time, and changes in NIH ability
to provide funding.teleconference caithness
com or (617) 225-0522, x 125
attacked summerville
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