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Interferon-gamma is
overexpressed in autoimmune diseases such as systemic lupus erythematosus ,
Crohn's disease and several forms of vasculitis. Based on the successful development and initial
registration of the products, NovImmune may receive up to $105 million in
future milestone payments . Securities and Exchange Commission.

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NI-0401 and NI-0501 are currently in preclinical development . While there are medications to help relieve
some of the disease symptoms, there is no known treatment to slow the
progression of Huntington's disease, which affects about 30,000 people in
North America .

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1 million, and a
net income of US$494.
About NovImmune
NovImmune is a Geneva -based product development company focusing on
immune mechanisms in order to clinically impact Immune Related Diseases,
Inflammation and Organ transplantation.
The HSG will be conducting a clinical study (TREND-HD) of ultra-pure
ethyl-EPA in persons 35 years of age or older who have mild to moderate
Huntington's disease.org or call the toll free number
+1-(800)-487-7671.

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The proliferation of activated T-cells is a hallmark of many
autoimmune diseases, including insulin-dependent diabetes , Crohn's disease,
multiple sclerosis and rheumatoid arthritis, and of organ transplant
rejection .

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- NI-0501 targets interferon-gamma, a key cytokine involved in the
regulation of immune and inflammatory responses.

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About Serono
Serono is a global biotechnology leader.com
http://www. This will be followed by
another 6 month observation phase in which all participants will receive
Miraxion.amarincorp.S.

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NI-0401 is
expected to enter clinical trials later this year .5 million,
convertible into shares of NovImmune on certain conditions or repayable with
accrued interest at maturity. Serono has no
responsibility to update the forward-looking statements contained in this
press release to reflect events or circumstances occurring after the date of
this press release. Individuals
with mild to moderate Huntington's disease who are interested in
participating in this study should visit the Huntington's Study Group website
at: http://www.

Many patients offer peeks in their journals, share their progression and treatments, discuss coping strategies and their experiences while battling lupus.

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Under the terms of the agreement, NovImmune is responsible for the
development of the two products until the completion of Phase IIa clinical
trials, after which Serono will take over further development.5 million
equity investment in NovImmune, and lend NovImmune up to CHF 7. These
factors include any failure or delay in Serono's ability to develop new
products, any failure to receive anticipated regulatory approvals, any
problems in commercializing current products as a result of competition or
other factors, our ability to obtain reimbursement coverage for our products,
the outcome of government investigations and litigation and government
regulations limiting our ability to sell our products.serono.novimmune.
For press releases and other corporate information, visit our website at
http://www. Such risks and uncertainties
include , without limitation, the inherent uncertainty of pharmaceutical
research, product development and commercialization, the impact of
competitive products and patents, as well as other risks and uncertainties
detailed from time to time in periodic reports.

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GENEVA, Serono (virt-x: SEO and NYSE:
SRA ) and NovImmune (private) have signed an exclusive agreement under which
NovImmune has granted Serono exclusive worldwide rights to develop and
commercialize two of NovImmune's fully human monoclonal antibodies, NI-0401
and NI-0501, which may have therapeutic potential in a broad range of
autoimmune diseases:
- NI-0401 targets the CD3 antigen, a key regulator in the activation of
T-cells .2 million, making it the third largest biotech company
in the world.
Huntington's disease is an inherited disease of the brain that usually
begins between the ages of 30 to 50, and includes motor, cognitive and
behavioral signs and symptoms."
About Amarin Corporation
Amarin Corporation plc is a neuroscience company focused on the
development and commercialization of novel drugs for the treatment of central
nervous system disorders.

Lupus:Personal Pages consolidates and shares lupus patients personal websites.

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In addition, NovImmune may receive further
milestone payments based on approval of the products for additional
indications, and will also be entitled to receive undisclosed royalties based
on eventual net sales of the products. NovImmune develops fully human
monoclonal antibodies, based on its direct access to both the transgenic
mouse lines and antibody display technology.
Rick Stewart, chief executive officer of Amarin, commented: "Commencement
of recruitment to the Phase III clinical trial for Miraxion is a major
milestone for Amarin. Miraxion , Amarin's lead development compound, is in
phase III development for Huntington's disease and in phase II development
for treatment-unresponsive depression.

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Serono and NovImmune to Collaborate in Development of Two Novel Treatments for Autoimmune Diseases

In 2004, Serono achieved worldwide revenues of US$2,458.A.
There is no cost to participate in the study. For more information, please
refer to Amarin Corporation's Annual Report for 2004 on Form 20-F and its
Form 6-Ks as filed with the U.

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and affiliates to be materially different from those expected
or anticipated in the forward -looking statements. The Company has eight
biotechnology products, Rebif(R), Gonal-f(R), Luveris(R ),
Ovidrel(R)/Ovitrelle(R), Serostim(R), Saizen(R), Zorbtive(TM) and Raptiva(R). NovImmune's
first product NI-0401 is expected to enter clinical trials in Q4 2005.

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"NovImmune is proud of this alliance as it represents a recognition of
the quality and clinical relevance of these products.

Our products can profit
from Serono's expertise in development and marketing across multiple
indications to maximize their full potential," declared Jack Barbut,
NovImmune's CEO.S.

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"We expect that NI-0401 and NI-0501 will have significant advantages
over precedent molecules and that those advantages will translate into
greater therapeutic potential for the treatment of chronic autoimmune
disorders . NovImmune has a strategic
partnership for GMP production with Lonza Biologics. Participants will be
followed as "out-patients" at regular intervals for 12 months. The
Company assumes no obligation to update information on its expectations.

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Phase III clinical trial of Miraxion(TM) in
Huntington 's disease.

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Securities and Exchange Commission on March 16, 2005.
http://www.

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Serono will
pay a license fee of $5 million for the two products, make a CHF 7. LONDON, Amarin Corporation plc (NASDAQ:
AMRN) today announced that the Huntington Study Group ("HSG") has commenced
recruitment for the U.
This current trial is designed to determine the effect of this daily dose of
Miraxion on motor (movement) signs and symptoms of Huntington's disease. Researchers at 43 sites in the United States and Canada will each
enroll approximately 7-8 research subjects with early signs of Huntington 's
disease who are independently ambulatory (walking) and fully self sufficient
in activities of daily living, such as eating, dressing and bathing.

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Such
statements are inherently subject to known and unknown risks, uncertainties
and other factors that may cause actual results, performance or achievements
of Serono S. Forward-looking statements
are based on Serono's current expectations and assumptions, which may be
affected by a number of factors, including those discussed in this press
release and more fully described in Serono's Annual Report on Form 20-F filed
with the U . Currently, there are approximately 30 ongoing development projects., the holding company, are traded on the virt-x (SEO) and its
American Depositary Shares are traded on the New York Stock Exchange (SRA).

Amarin Announces Commencement of Recruitment by Huntington Study Group for Miraxion Phase III Clinical Trial in Huntington's Disease

com.

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S. The Company's research programs are focused on
growing these businesses and on establishing new therapeutic areas, including
oncology.com

Miraxion is thought to stabilize nerve cell membranes and improve
neurological functioning, although the exact mechanism of action is not
currently known. An earlier trial in subjects with Huntington 's disease
indicated that Miraxion at 2 grams daily was well tolerated over 12 months.

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"More specifically , NI-0401, which should enter the clinic
later this year, addresses a basic mechanism of the immune response and could
be efficacious in treating numerous different immune related diseases.A. Bearer shares of
Serono S.seronousa.
The current 12 month study includes a 6 month placebo controlled phase
with research subjects being randomly assigned to receive either Miraxion (2
grams total daily dose) or a matching placebo. An immense amount of energy and dedication has been
expended by all involved to achieve this significant objective.
Statements in this press release that are not historical facts are
forward-looking statements that involve risks and uncertainties which may
cause the Company's actual results in future periods to be materially
different from any performance suggested herein.

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"
"NovImmune has used state-of-the-art technologies to design antibodies
with very distinctive properties," said Tim Wells, Head of Research at
Serono."
For Serono
Some of the statements in this press release are forward looking.
In addition to being the world leader in reproductive health, Serono has
strong market positions in neurology, metabolism and growth and has recently
entered the psoriasis area. Its products are sold in over 90 countries.com
http://www.Huntington-Study-Group.

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In addition, NovImmune
is developing a new class of immunosuppressors and anti-inflammatory agents
as low molecular weight inhibitors of MHC Class II expression, directed
against highly specific and totally validated protein targets. The HSG is a worldwide, not-for-profit group of
physicians and other clinical researchers who are experienced in the care of
Huntington 's disease patients and dedicated to clinical research in
Huntington's disease.