The PFS rate at
18-weeks (end of treatment period) increased by 13% (a 30% relative
improvement) and 16% (a 36% relative improvement) in the ITT and evaluable
patients, respectively . The Company has seven Phase II human clinical
trials currently underway in the treatment of cancer and diabetic foot ulcers,
with company sponsored U. In the
reexamination process, CollaGenex successfully demonstrated to the
Patent Office that enhancement of bone protein synthesis using
Periostat(R ), a sub-antimicrobial dose of doxycycline, is patentable
over all patents and publications identified in the reexamination.com, which does not form part of this press
release.

Business Editors /Health/Medical Writers

TEMECULA, Calif.
Some of us in the industry have been attempting to increase awareness
of the dangers, but laws, enforcement budgets and attitudes have not
caught up with the ugly reality.pmed.

forays plagiarism

The confirmed response rate in all 110 randomized intent-to-treat (ITT)
patients increased from 27% with placebo to 42% with talactoferrin, a 15%
absolute increase and a 56% relative increase.

In that case CollaGenex alleges that the
Defendants' submissions of ANDA's covering their 20mg tablets of
doxycycline hyclate infringe the '656 Patent. CollaGenex is seeking an
injunction preventing the Defendants from introducing 20mg tablets of
doxycycline hyclate into the market in the United States. The Company's professional dermatology sales force
markets Pandel(R), a prescription topical corticosteroid licensed from
Altana, Inc. CollaGenex
assumes no obligations to update the information included in this
press release.

flagged tempting

Data on the primary endpoint (best overall response by
CT scan using RECIST criteria) was presented at the American Association for
Cancer Research (AACR) annual meeting last month.I.com. Periostat is the first and only pharmaceutical
to treat periodontal disease by inhibiting the enzymes that destroy
periodontal support tissues and by enhancing bone protein synthesis.----The following is
an Opinion Editorial from Patrick M . Schmidt, president and CEO of FFF
Enterprises Inc. No worries, right?
Now imagine that scenario , but replace the jeans with a
manufacturer's lot of immune globulin, a human plasma product infused
into patients with severe immune deficiencies to increase their
infection-fighting antibodies . These conditions continue to allow
irresponsible distributors to resell damaged medicines; pharmacies to
resell excess inventory to gray-market buyers; and criminals to become
licensed pharmaceutical distributors. www.

cheating snoops

2 million
cases of lung and bronchial cancer diagnosed each year worldwide, causing
approximately 1.----CollaGenex
Pharmaceuticals, Inc.
CollaGenex Pharmaceuticals, Inc. Currently , the Company's professional
dental pharmaceutical sales force markets Periostat, which is
indicated as an adjunct to scaling and root planing for the treatment
of adult periodontitis., for the treatment of adult
periodontitis.

Forward-Looking Statements

Statements in this press release regarding management's future
expectations, beliefs, goals, plans or prospects, including statements
relating to the Company's intellectual property rights, its ongoing
litigation with IVAX and CorePharma , and its future development
efforts, may constitute forward-looking statements within the meaning
of the Private Securities Litigation Reform Act of 1995.

All other trade names, trademarks or service marks are the
property of their respective owners and are not the property of
CollaGenex Pharmaceuticals, Inc.

Last March, the United States Attorney for the Southern District
of Georgia indicted Bio-Med Plus, which claimed to be one of the
nation's largest plasma products distributors, along with the
company's owners and some associates, on 288 counts, including
racketeering , related to the alleged purchase and sale of fraudulently
obtained human plasma products and other prescription drugs.org/perlserv/
?request=get-document+doi=10.

deterring misplaced

Talactoferrin appeared to be safe and
well tolerated with no drug-related significant adverse events.

Business Editors/Health /Medical Writers

NEWTOWN, Pa. In addition, CollaGenex has licensed the Restoraderm(R)
technology , a unique, proprietary dermal drug delivery system, and
plans to develop a range of topical dermatological products with
enhanced pharmacologic and cosmetic properties.
You would never know if a manufacturer 's lot of your favorite
jeans is sold by the maker to a wholesaler, which sells it to some
distributors , one of which sells a case to another distributor, which
tosses it into the back of a pickup truck and then sells it to a local
discount store, where it sits on a loading dock for a couple hours
before being put into inventory.
This may be hard to believe, but it is well documented in a new
book about drug counterfeiting called "Dangerous Doses" by
investigative journalist Katherine Eban.
When patients demand safe medicines is when channel integrity will
become the rule, not the exception .fffenterprises.

plagiarism cheating

The addition of oral talactoferrin to carboplatin/paclitaxel (C/P)
enhanced the patients' response to chemotherapy on all the tumor related
endpoints including response rate , progression free survival (PFS), time to
response, and duration of response. I look
forward to seeing results in a Phase III trial with a larger number of
patients that can help to confirm talactoferrin's importance in this patient
population. C/P was administered in 3-week cycles (C: AUC 5
mg/mL/min; P: 175 mg/m(2)).S. (Nasdaq:CGPI) today announced that the United
States Patent and Trademark Office has issued a Notice of Intent to
Issue a Reexamination Certificate confirming the patentability of
certain amended claims of United States Patent RE 34,656 (the "'656
Patent "), of which CollaGenex is the exclusive licensee.
CollaGenex recently filed a complaint for patent infringement
against both IVAX Pharmaceuticals Inc.
You should think about the pharmaceutical supply channel, because
such scenarios are not imaginary but real, and they occur with
frightening frequency.html#creation

(2) PloS Medicine, Vol 2, Issue 4, April 2005.

forays plagiarist

About Talactoferrin Alfa
Talactoferrin alfa is a novel immunostimulatory agent with demonstrated
anti-cancer activity in animals and NSCLC patients in Phase I/II trials.
The dental sales force also promotes Atridox (R), Atrisorb FreeFlow(R)
and Atrisorb-D FreeFlow(R), which are products of QTL, Inc. Oracea is currently in Phase III clinical trials to
evaluate its effectiveness in treating rosacea, a dermatological
condition.collagenex.

fraudulently flattery

Talactoferrin has been administered to over 500 people and appears safe and
well tolerated.
The immune globulin would obviously be in bad condition, perhaps even
deadly .

flattery proliferating

The median time to first response decreased by 1.

Periostat is a registered trademarks of CollaGenex
Pharmaceuticals, Inc. The book reads like a
thriller, because the traditional channel has all the intrigue and
criminality of one. "Dangerous Doses" recounts the investigation of a
network of small distributors that made gargantuan profits allegedly
selling stolen and counterfeit pharmaceuticals out of garages and car
trunks.
What is the solution to the dangers of our pharmaceutical supply
channel?
I have worked in this industry since 1988, and I have learned that
the channel is only as good as the people in it.

webography ravages

The
patients were randomized (1:1) to receive standard therapy (C/P) plus either
talactoferrin or placebo. or any of our subsidiaries. You just go
shopping, and there they are. But it is not just the small fries that reap big bucks in
illicitly obtained and fake pharmaceuticals. Were the channel secure,
such unscrupulous suppliers would not be able to obtain vaccine.

webography plagiarized

Anderson
Cancer Center and member of Agennix's Scientific Advisory Board commented:
"This data suggests that adding talactoferrin, an immune stimulating agent, to
standard chemotherapy substantially improves clinical results in non-small
cell lung cancer. In
animal experiments , oral talactoferrin induced the proliferation of NK-T and
CD-8+ cells and potentiated the anti-cancer activity of standard chemotherapy.
Talactoferrin appears to be safe and well tolerated after administration to
over 500 people, and appears to be effective in treating cancer and diabetic
foot ulcers. INDs in both areas. Schmidt is the president and CEO of FFF Enterprises
Inc.fda.

proliferating deterring

Results from
tumor related secondary endpoints were presented today at the 2005 Annual
Meeting of the American Society of Clinical Oncology (ASCO) in Orlando.3
months (a 50% improvement).

About Non-Small Cell Lung Cancer
Lung cancer is responsible for nearly 30 percent of cancer deaths in the
United States, according to the National Cancer Institute. Almost 80 percent of lung cancer is
non-small cell. and CorePharma LLC
("Defendants") in the United States District Court for the Eastern
District of New York.0020100


(Due to the length, these URLs may need to be copied/pasted into
your Internet browser's address field. Remove the extra space if one
exists.

webography proliferating

Dr.
More information about Agennix is available on the Company's web site at
http://www.agennix.

U.S. Patent and Trademark Office Notifies CollaGenex That It Will Confirm Claims of Reexamined Periostat Patent

"This is an important step for us and justifies our decision to
seek reexamination as part of our strategy to enforce our patent
rights.
Even the FDA's comprehensive 2004 anticounterfeiting taskforce
report (1) hasn't resolved the resistance to regulation, lack of
resources, and complacency.com

(1 ) "Combating Counterfeit Drugs, A Report of the Food and Drug
Administration" February 2004.

plagiarist proliferating

Talactoferrin was combined with standard chemotherapy and compared to placebo
plus standard chemotherapy in first -line treatment of advanced non-small cell
lung cancer (NSCLC).6 months (14%
improvement) and 2 . It is especially encouraging that patients are also showing
an improvement in all of the tumor related secondary endpoints., in 35-day cycles for up to three cycles or until
radiological progression , starting the day following C/P dosing in chemo-
cycles 1, 3 and 5. All 110 patients were evaluable for safety, and were
included in the ITT population.

Is Your Medicine Safe?

Imagine that the distributor dilutes the immune globulin
with tap water, counterfeits some packaging and then sells the tainted
product to another distributor, which sells it to the local pharmacy. The industry must embrace this model, and consumers must
demand it of us all -- to keep drugs and patients safe.

expulsion misplaced

05). The 100 patients who had at least one CT scan
after starting treatment were included in the prospectively defined evaluable
population. CollaGenex is further evaluating
Periostat and other IMPACS(R) compounds , including Oracea(TM), to
assess whether they are safe and effective in these other
applications .
To receive additional information on the Company, please visit our
Web site at www. CollaGenex 's
actual results could differ materially from those stated or implied in
forward-looking statements due to a number of factors, including those
factors contained in CollaGenex's most recent Annual Report on Form
10-K for the year ended December 31, 2003 and the most recent Form
10-Q for the Quarter ended September 30, 2004 under the sections
"Additional Factors That May Affect Future Results " and "Additional
Risks That May Affect Results" as well as other documents that may be
filed by CollaGenex from time to time with the Securities and Exchange
Commission.

cheating forays

The trial met its primary
endpoint of detecting an improvement in response rate (p=0.05), an 18% absolute improvement and a 62% relative improvement. The Company is the owner or exclusive licensee of a number of
issued and pending patents that cover both our marketed and pipeline
products, and we will continue to do all that we can to enhance the
intellectual property protections of our products.
Research has shown that certain unique properties of the
tetracyclines discovered during the development of Periostat may be
applicable to other diseases involving inflammation and/or destruction
of the body's connective tissues.
There is a dangerous lack of integrity in the traditional channel. The problem is rampant:
According to an industry publication, one in seven drugs worldwide is
fake -- that's $35 billion annually in counterfeit drug sales(2)!
In the United States today, pharmaceutical supply channel
integrity is the exception, when it should be the rule.plosjournals.

tempting plagiarized

Talactoferrin (or placebo) was administered
orally, 1500 mg B.D. The primary endpoint was best overall response by CT scan
using RECIST criteria. Forward-looking statements include statements regarding
CollaGenex's expectations , beliefs, intentions or strategies regarding
the future and can be identified by forward-looking words such as
"anticipate", "believe", "could", "estimate", "expect", "intend",
"may", "should ", "will", and "would" or similar words.
http://www.
http://medicine.

ravages deterring

The
median PFS increase in the ITT and evaluable patients was 0. Waun Ki Hong, head of the Division of Cancer Medicine at M .1 million deaths annually.

About Agennix
Agennix, a privately owned Houston-based biopharmaceutical company, is
developing patented protein and peptide drug candidates including
talactoferrin alfa (talactoferrin), an immunostimulatory protein.
Although the reexamination procedure is recognized as extremely
rigorous, it is not predictive of the outcome of this decision.

Atridox, Atrisorb and Atrisorb-D are registered trademarks of QTL,
Inc.)

plagiarism proliferating

The confirmed response rate in
the 100 prospectively defined evaluable patients increased from 29% to 47%
(p=0. The median duration of response has not yet been
reached, but currently shows a 1.
CollaGenex also overcame rejections based on double patenting over
subject matter already covered in CollaGenex's earlier '897 patent ,
which has now expired., the
successor to Atrix Laboratories, Inc.

Patrick M.

plagiarized cheating

Results from a Double-Blind, Randomized, Placebo-Controlled Phase II Trial
Presented at ASCO

HOUSTON, Agennix Incorporated announced results
from a double-blind , randomized, placebo-controlled, multi-center Phase II
clinical trial evaluating oral talactoferrin alfa (talactoferrin).D. One hundred and ten (110) chemo-naive patients
with advanced or metastatic NSCLC were enrolled at eleven cancer centers.

expulsion fraudulently

5 months (61% improvement), respectively."

About the Study
The goal of this randomized, double-blind, placebo-controlled Phase II
study was to determine if talactoferrin improves the effectiveness of a
standard first-line chemotherapy regimen (carboplatin/paclitaxel; C/P) in
patients with advanced NSCLC. More than 173,000
people in the United States will be diagnosed with lung cancer this year, and
according to the World Health Organization there are more than 1. We believe that our
intellectual property positions us well to develop our future business
in the dental and dermatology markets," said Colin Stewart, president
and chief executive officer of CollaGenex. The shortage was severe in some
areas, and the price gouging damaged the national effort to direct the
limited vaccine supply to priority patients.

expulsion misplaced

is a specialty pharmaceutical
company focused on providing innovative medical therapies to the
dental and dermatology markets .
Do you ever think about the supply channel for the products you
buy? Do you wonder how they travel from the manufacturer to the
department store or grocery or pharmacy? Probably not. Would it be safe? Probably not. Imagine that one of those
distributors is a gray marketer, someone who will do anything to make
a profit.gov/oc/initiatives/counterfeit/
report02_04.

channelled flattery

3 month (30%) increase relative to placebo. The jeans are still in perfect
condition. Would the immune globulin still be in
perfect condition? Probably not.
But a company doesn't have to resort to racketeering to violate
the integrity of the supply channel. I have also learned
that the most effective, economic solution is channel integrity as my
company defines it: Buy only from the manufacturer, ship only to
healthcare providers , and track every unit of medicine throughout the
channel.

plagiarism plagiarize

CollaGenex
is still awaiting the Court 's decision with respect to the injunction.
The scenario can be even worse., the nation's largest privately held biopharmaceuticals, plasma
products, vaccines and clinical trial drugs distributor , with
headquarters in Temecula.

snoops sparknotes

Agennix's Oral Talactoferrin Improved Response Rates Time to Progression and Duration of Response When Combined With First-Line Chemotherapy in Advanced Non-S

Current treatments for lung cancer include surgery,
chemotherapy, radiation, and targeted molecular therapy, in spite of which
there are over 160,000 deaths per year in the United States alone. Agennix holds 76 patents on this molecule, including broad
composition of matter coverage.

Pandel is a trademark of Taisho Pharmaceuticals. Imagine that the lot of immune globulin
is sold by the manufacturer to a wholesaler, which sells it to some
distributors, one of which sells a case to another distributor , which
tosses it into the back of a pickup and then sells it to a local
pharmacy, where it sits on a loading dock for a couple hours before
being put into inventory.
During last year's flu vaccine shortage, price gouging by
gray-market distributors was common.1371/journal.

ravages fraudulently

---

- - kjjkjk

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