"
D3P has a dedicated marketing division with expertise in a variety
of disciplines, including product brand marketing, distribution, price
point evaluation, promotion and advertising.
"The results of these studies demonstrate our ability to identify novel
synthetic DNA agonists that can modulate immune responses through Toll-Like
receptors," commented Sudhir Agrawal , D. "As the TLR9 agonists are potentially
applicable to treat a wide variety of diseases including cancer, asthma,
allergies, and infectious disease, compounds that can create different immune
responses may be used to produce drug candidates that are more disease-
specific. Hybridon disclaims any intention or obligation to update
any forward-looking statements. A case study
on Nike highlights how it used multimedia learning to build
sell-through skills in its floor sales staff.com

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CAMBRIDGE, Mass.
The paper entitled 'Immunomodulatory oligonucleotides containing a
cytosine -phosphate-2-deoxy-7-deazaguanosine motif as potent Toll-like receptor
9 agonists' was published in the May 10th, 2005 issue of PNAS (vol.

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(BVG), the interactive entertainment arm
of The Walt Disney Company (NYSE:DIS), today announced a distribution
deal with Tokyo-based, D3 Publisher, Inc. 102 , pp
6925-6930).

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The division publishes, markets and
distributes a broad portfolio of multi-platform video games and
interactive entertainment worldwide. Without limiting the foregoing, the
words "believes," "anticipates," "plans," "expects," "estimates," "intends,"
"should," "could," "will, " "may," and similar expressions are intended to
identify forward-looking statements.

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"Tim Burton 's The Nightmare Before Christmas" continues to gain
many core fans since the film was released in theaters throughout
Japan in 1994.
Lewis' beloved literary classic, from Walt Disney Pictures and Walden
Media. The company also licenses
properties and works directly with third-party interactive game
publishers to bring products for all ages to market., Hybridon, Inc. To read the article,
visit www.

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The game is scheduled
for release in summer 2005., Chief Executive Officer and
Chief Scientific Officer of Hybridon. For more information
please visit our website at http://www.

Contacts:
Hybridon, Inc. Yet the emotion and media
hysteria hide a story about the analytical way the Red Sox
accomplished this goal.

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A television
series aired from April to December 2004, and the characters have
gained tremendous popularity throughout Japan.Phil.hybridon.

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----

Games Line Up to Include "The Chronicles of Narnia," "Disney's
Chicken Little," "Tim Burton's The Nightmare Before Christmas" for
Game Boy(R) Advance, and Multiple Disney Channel Titles

Buena Vista Games, Inc. The series also began
airing on TV Tokyo Networks, a terrestrial broadcasting service , in
April 2005.com

This Learning Solutions feature in the March
issue of Chief Learning Officer magazine looks at strategies to help
CLOs contribute to their company's competitive advantage .

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The game is schedule for release in summer 2005.buenavistagames.CLOmedia.

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The film is scheduled to release in theaters in
December 2005 in Japan, and the release of the game will coincide with
the film's release.com

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About Disney properties in Japan:

The animated television series "Kim Possible" made its debut on
the Disney Channel in Japan in November 2003. (BVG) is the interactive entertainment arm
of The Walt Disney Company. For more
information, please log on to www.

About Hybridon
Hybridon, Inc. MacDougall Biomedical Communications
617-679-5500, x5526 508-647-0209 x12
Tim Sullivan Douglas MacDougall
E-mail: doug@macbiocom.

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"It's important for BVG to partner with a company that possesses
strong marketing acumen, as well as proven experience meeting the
retail community's needs," said Graham Hopper, senior vice president
and general manager of Buena Vista Games.S. Inspired by the movie, the game will launch in conjunction with
film's release in Japan in spring 2006. The Company's nucleic acid chemistry expertise has also
generated a portfolio of partnered products and intellectual property,
creating the potential for long-term value for Hybridon .

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Business Editors/Entertainment Editors/Video Game Writers

BURBANK, Calif.
"Disney 's Lilo + Stitch" was a box office success throughout
Japan, when it premiered in theaters in March 2003.

About Buena Vista Games

Buena Vista Games, Inc.

Hybridon Publishes Data on Novel Synthetic Agonists of Toll-Like Receptor 9

The results published in the recent issue of the
Proceedings of the National Academy of Sciences USA (PNAS) described immune
stimulation effects of representative proprietary compounds from different
classes of synthetic TLR9 agonists using cell-based assays and studies in mice
and monkeys."
Hybridon's lead compound, IMOxine(R), is in Phase II clinical trials for
Renal Cell Carcinoma. There are a number of important factors
that could cause Hybridon 's actual results to differ materially from those
indicated by such forward-looking statements, including risks as to whether
results obtained in preclinical studies such as the studies referred to in
this release or early clinical trials will be indicative of results obtained
in future preclinical studies or clinical trials, or warrant further clinical
trials and product development; whether products based on Hybridon's
technology will advance through the clinical trial process and receive
approval from the United States Food and Drug Administration or equivalent
foreign regulatory agencies; whether , if such products receive approval, they
will be successfully distributed and marketed; whether the patents and patent
applications owned or licensed by Hybridon will protect the Company's
technology and prevent others from infringing it; whether Hybridon's cash
resources will be sufficient to fund product development; whether the
Company's collaborations will be successful; and such other important factors
as are set forth under the caption "Risk Factors" in Hybridon's Annual Report
on Form 10-K filed on March 25, 2005, which important factors are incorporated
herein by reference.

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CLO Magazine Explores Non-Traditional Approach to Learning

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(D3P) to release multiple
BVG games in Japan. The Game Boy Advance game is scheduled for release in
time for the 2005 Halloween season.

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The story holds several correlations for
learning professionals.

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D3P has also
established a 24-hour customer service unit to answer questions from
end consumers.
"The Chronicles of Narnia: The Lion, The Witch and The Wardrobe"
is a spectacular live action/CGI motion picture adaptation of C. is developing novel therapeutics based on synthetic nucleic
acid chemistry for the treatment of cancer, asthma/allergies , and infectious
diseases. Hybridon's proprietary IMO drug candidates are designed to modulate
immune responses through Toll-like receptors, the body's first line of defense
against disease.

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"We believe D3 Publisher has
established itself as a premier video game distributor and will help
strengthen BVG's presence in the Japanese marketplace.
This press release contains forward-looking statements concerning Hybridon
that involve a number of risks and uncertainties.

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Buena Vista Games Signs Agreement With D3 Publisher To Distribute BVG Games in Japan

Titles to include "The Chronicles of Narnia: The
Lion, The Witch, and The Wardrobe" on multiple platforms including
PlayStation(R)2 and Game Boy(R) Advance; "Disney's Chicken Little" on
multiple platforms including PlayStation(R)2 and Game Boy(R) Advance;
"Tim Burton's The Nightmare Before Christmas" for Game Boy(R) Advance;
Disney 's "Kim Possible" for Game Boy(R) Advance; and Disney's "Lilo +
Stitch" for Game Boy(R) Advance.
"Disney's Chicken Little" is the first full-3D animation by The
Walt Disney Company.com. For this purpose, any
statements contained herein that are not statements of historical fact may be
deemed to be forward-looking statements.

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Business Editors

CHICAGO----

Nike Deploys Learning to Affect Underground Sales

Even non-sports fans know that the Boston Red Sox won their first
World Series in 86 years this past fall.

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D3P plans to roll out
television advertising programs for BVG's product line that have
direct tie-ins with Disney's television programming. (Amex:
HBY) today announced the publication of results of preclinical studies on
novel DNA compounds , designed by Hybridon, that activate TLR9 and induce
distinct immune responses.

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---

- - kjjkjk

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