Business Editors

PORT WASHINGTON, N.

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relationship loeb

m. Pursuant to a product development and commercialization
agreement between Exelixis and GSK, GSK has the option, after completion of
clinical proof-of-concept by Exelixis, to elect to develop a certain number of
compounds in Exelixis' product pipeline, which may include XL784 and the
cancer compounds identified in this press release (other than XL119), thus
potentially triggering milestone payments and royalties from GSK and
co-promotion rights by Exelixis.----Systemax
Inc.

Forward-Looking Statements

This press release may contain forward-looking statements about
the Company's performance.

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SOUTH SAN FRANCISCO, Calif.

nathan crime

Exelixis Announces March 30th Webcast of Presentation at the 13th Annual Future Leaders in Biotech Industry Conference

Exelixis' development pipeline covers cancer
and metabolism and is comprised of the following compounds: XL119
(becatecarin), for which a multinational Phase 3 clinical trial in bile duct
tumor is ongoing and which has been exclusively licensed to Helsinn Healthcare
S.Y.systemax.

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Scangos, Ph.

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exelixis .com. Leeds added that approximately 100
positions are being eliminated, which is expected to result in
approximately $3.com) utilizes an integrated system of
branded e-commerce web sites, direct mail catalogs and relationship
marketers to sell PC hardware, related computer products and
industrial products in North America and Europe.

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(NYSE:SYX), a leading distributor and manufacturer of PC
hardware , related computer products and industrial products in North
America and Europe announced today that it is taking steps to increase
the efficiency and profitability of its UK operations. Please refer to
the Forward Looking Statements section contained in Item 7 of the
Company's Form 10-K for a more detailed explanation of the inherent
limitations in such forward-looking statements.

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is a
Fortune 1000 company.

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4 million in annual savings.

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, Exelixis,
Inc.
Exelixis has established broad corporate alliances with major pharmaceutical
and biotechnology companies including GlaxoSmithKline (GSK) and Bristol-Myers
Squibb Company.

These statements are based on management's
estimates , assumptions and projections and are not guarantees of
future performance.

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; XL784, which is being advanced as a treatment for renal disease and
expected to enter Phase 2 early in 2006; XL999, an anticancer compound,
currently in Phase 2 clinical trials for a variety of solid tumors; XL647,
XL880 , XL820, XL844 and XL184, anticancer compounds currently in Phase 1
clinical trials; and multiple compounds in preclinical development for
diseases including cancer and various metabolic and cardiovascular disorders. For more information, please visit the
company's web site at http://www." Mr. Actual results may differ materially from results
expressed or implied in these statements as the result of risks ,
uncertainties and other factors including, but not limited to: (a)
unanticipated variations in sales volume, (b) economic conditions and
exchange rates, (c) actions by competitors, (d) the continuation of
key vendor relationships, (e) the ability to maintain satisfactory
loan agreements with lenders , (f) risks associated with the delivery
of merchandise to customers utilizing common carriers, (g ) the
operation of the Company's management information systems, and (h)
unanticipated legal and administrative proceedings.

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(PST) / 11:00 a. Systemax Inc. The Company assumes no obligation to update these
statements.

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Richard Leeds, Chairman and Chief Executive Officer, stated, "By
combining certain back office operations we will increase efficiency,
provide better customer service and at the same time reduce costs and
increase profitability.

loeb richard

The presentation will be webcast and may be accessed in the Event Calendar
page under Investors on the Exelixis website at http://www .

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society richard

D.exelixis.

Systemax Announces UK Streamlining and Reorganization Reducing Costs

loeb explication

(EST) on Thursday , March 30, 2006. The company is
leveraging its fully integrated gene-to-drug platform to fuel the growth of
its proprietary drug pipeline.

Sites about the Leopold

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president
and chief executive officer of Exelixis, will present at the 13th Annual
Future Leaders in Biotech Industry Conference at 8:00 a. is a biotechnology company dedicated to the discovery and
development of novel therapeutics that will potentially enhance the care and
lives of patients with cancer and other serious diseases .A.

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com.

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(Nasdaq: EXEL) announced today that George A.

About Exelixis
Exelixis, Inc .

Systemax (www.