"One in particular involves improving the design of
intelligent agents in entertainment software as found in massively multiplayer
online games.

gabor heiser

tomography heiser

LA JOLLA, Calif." The technology
relies on evolutionary computing to adapt plans in light of evolved enemy
courses of action (known as eCOAs ) in a sequential manner, where each side
anticipates what the other will do for a period of time projected into the
future. Part of the SBIR Phase II project involves the parallelization of
Natural Selection, Inc. was founded in 1993 to address complex problems in
industry, medicine, and defense .

csl.

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S.
"There are numerous commercial applications of this technology as well,"
offered Dr.

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The contract's principal investigator is Dr.
The NIGMS grant provides support for the mathematical modeling of
complex mammalian signaling and other biological networks, using SRI's
unique formal methods tools."

About SRI International

Silicon Valley-based SRI International (www.

photorealistic semantics

Air Force Research Laboratory to develop technology to
evolve courses of action for mission planning , such as is required in unmanned
aerial vehicle (UAV) operations. The company possesses unique expertise in
computational intelligence techniques, including evolutionary computation,
neural networks , and fuzzy logic. Ultimately, we
intend to make our integrated and interactive online Pathway Logic
tools available to a wide community of biologists and biomedical
researchers.com) is one of the
world's leading independent research and technology development
organizations.

heiser logics

Promoting the mathematical modeling of
biological systems is a primary goal of NIGMS, which intends to
disseminate such tools to biologists to help them understand the new
paradigm of systems biology and to design experiments .

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, Natural Selection, Inc.'s evolutionary computing tools on a cluster of
personal computers.com /.----SRI
International, an independent, nonprofit research and development
institute, today announced continuation of an important grant from the
National Institute of General Medical Sciences (NIGMS , a unit of the
National Institutes of Health) to model complex mammalian signaling
networks based on signaling of the epidermal growth factor receptor
(EGFR). SRI developed some of these tools
as part of a Web-based Pathway Logic viewer that allows multiple
queries of graphical models of EGFR biochemistry.

predicate logics

" Natural Selection, Inc. is now in the second year of a
National Science Foundation SBIR Phase II grant to develop evolutionary
computing and neural network technology to improve the performance of
characters in entertainment software and reduce the time required to develop
and test new games.

Natural Selection, Inc. Torrey Pines Ct.

hesselink persistence

"We have developed new methods of employing evolutionary algorithms
to make real-time course-of-action planning and replanning feasible ," said Dr.

Business Editors/Health/Medical Writers/High-Tech Editors
BIOWIRE2K

MENLO PARK, Calif. This could
dramatically speed drug development and improve the safety of new
drugs -- major issues for pharmaceutical and biotechnology companies
today. The support of NIGMS is helping to make this possible.

persistence petri

has
been awarded a $748,848 Phase II Small Business Innovation Research (SBIR )
contract from the U.
Fogel.
In the project's first phase, SRI demonstrated a novel
computational approach to help researchers create, analyze, and test
models of complex EGFR signaling networks .sri.

logics petri

correctness furio

Suite 200
La Jolla, CA, 92037
tel: (858) 455-6449
fax: (858) 455-1560
dfogel@natural-selection.
The ultimate research goal of Pathway Logic is to create models of
large-scale signaling networks in defined cell types -- computational
models of mammalian cells defined in terms of their molecular
responses to specific environmental signals . The
nonprofit research institute performs client-sponsored research and
development for government agencies, commercial businesses and
nonprofit foundations.

petri logics

This phase will include
development of the Pathway Logic Assistant, an application of the
InterOperability Platform (IOP), a separately funded research project
to enable the formal methods tools written in the Maude language to
communicate and interact with each other.

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David B.

hopper stabilizing

Fogel
CEO
Natural Selection, Inc.

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3333 N.
In the second phase of the project, SRI will increase the utility
and predictive capabilities of Pathway Logic by enhancing the ability
of researchers to interact with the models. "This feature is one means by which
Pathway Logic offers the potential for researchers to model complex
cellular networks in a familiar or intuitive way. In addition to conducting contract R+D, SRI
licenses its technologies, forms strategic partnerships and creates
spin-off companies.

predicate logics

David Fogel, CEO of Natural Selection, Inc.

gabor persistence

Natural Selection Inc. Wins U.S. Air Force SBIR Phase II

com

and please visit our web site at http://www .

SRI International Begins Second Phase of National Institute of General Medical Sciences Grant for Mathematical Modeling of Biological Systems; Formal Method To

sri. Founded as Stanford Research Institute in 1946 , SRI has
been meeting the strategic needs of clients for almost 60 years.

tomography hannaford

The technology we are developing will allow
mission planners to optimize courses of action on-the-fly, while considering
what the responses of opposing forces are likely to be.

halper correctness

Fogel.natural-selection. With IOP as the
infrastructure, SRI researchers will begin to integrate a user
interface, a model repository, new visualization tools, and various
biological databases into Pathway Logic.

halper stabilizing

The corporation's research efforts support
the discovery of new pharmaceuticals, the automated detection and discovery of
important patterns and processes in bioinformatics and medical informatics,
computer-assisted diagnosis, and a variety of military and industrial
projects. The approach uses SRI's
patent-pending Pathway Logic(TM) pathway analysis software, based on
the Maude computer language (http://maude.

gabor uncertainty

tomography gernot

: "There is a critical need for
combat simulations to incorporate intelligently interactive agents , both for
mission planning and training.

For more information, please contact:

Dr. Longer term,
these tools may prove useful in validating novel therapeutic targets
and predicting the side effects of experimental therapies.com/), to model
biological entities and processes.
"Pathway Logic models of biological systems are unique in that
they are executable -- the models exist only when assembled on demand
from user-defined starting states," said Keith Laderoute, director of
SRI's Cancer Biology Program.

photorealistic resilience

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