* Among those taking antipsychotics , most (74%) also feel their current
medication falls short in controlling depression while 49% of all
respondents said their doctors place "a great deal" of importance on
depression when making treatment decisions. The survey shows that
more than 75 percent of patients on antipsychotic medications gain weight and
of those who said they gained weight, the average weight gain is 52 pounds.
In addition to Drs.

imcs dodgson

The authors advise that factors such as side effect profiles are
predictable and individual preferences should be considered.
People with schizophrenia agree with the optimistic views expressed in the
consensus statement. In addition, interest and
motivation are diminished and many individuals become depressed and socially
withdrawn. Primary Psychiatry addresses the significant comorbid
interface between psychiatry and primary care medicine . Graybiel is investigating the relationship of these
functions using neuronal recordings and genetic analyses.

neurofuzzy wlodzislaw

These Untreated Symptoms are Roadblocks to Patient Recovery

NEW YORK, Treatment of schizophrenia has largely
focused on controlling positive symptoms, such as hallucinations and
delusions, while another set of symptoms that are equally important to
patients is frequently overlooked by physicians, according to the findings of
a new national consumer survey and the authors of a new consensus statement
aimed at raising the bar for the treatment of the brain disease.

* Among those taking antipsychotics, 77% said their medication does not
adequately help their ability to focus and concentrate."
Studies suggest that atypical antipsychotics improve cognition better than
older antipsychotics, but even atypical antipsychotics differ in their ability
to treat these symptoms. The affective and cognitive problems associated with schizophrenia
may be important factors in long-term outcome.

diwan denning

com/proceedings. adults 18+
who have been diagnosed with schizophrenia, who have switched schizophrenia
medications at least once and who were members of the Harris Interactive
Chronic Illness Panel. Her lab has cloned a novel gene that affects these
behaviors, which is enabling her to explore the basal ganglia's role
in dysfunctions involving repetitive behavior, pattern generation, and
movement.

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About Schizophrenia
Schizophrenia is a seriously debilitating mental illness characterized by
distortions of reality and disturbances in perception, mood, cognition,
motivation, social function and motor behavior.mblcommunications .
Rosenblith Professor for Neuroscience at MIT, is receiving the 2005
Ibsen Neuronal Plasticity prize for "outstanding work.

refinement concurrency

Yet "dealing with affective and cognitive
impairment has not yet become prominent on the clinical horizon," according to
Nina R. Weiden, Schooler and Harvey, Peter F.

The Optimizing Treatment of Schizophrenia: Enhancing Affective/Cognitive
and Depressive Functioning supplement and survey are sponsored by Pfizer Inc
and coordinated by Chandler Chicco Agency.

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The basal ganglia are known to
be involved in neurological diseases, like Parkinson's and
Huntington 's, and neuropsychiatric disorders, like obsessive
compulsive disorder, depression, and addiction .

diwan wavelets

The cause of schizophrenia is unknown,
but it is believed to be the result of abnormal brain functioning .in the domain
of Motivation and Associative Learning.

modal refinement

Comprehensive treatment of all schizophrenia symptoms is possible and many
people with schizophrenia can now recover in ways not previously thought
possible, according to the panel of nationally recognized psychiatrists and
psychologists whose discussions and recommendations are published in a
supplement to the current issues of Primary Psychiatry and CNS Spectrums (CNS
Spectr. Weight gain in
particular has become a problem with some medications .

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Harvey, PhD,
professor of psychiatry at Mount Sinai School of Medicine and chief
psychologist at Mount Sinai Hospital, an author of the statement.
Schizophrenia is associated with changes in cognition that affect the ability
to remember and to plan for achieving goals.

About the McGovern Institute at MIT

The McGovern Institute at MIT is a research and teaching institute
committed to advancing human understanding and communications.

imcs diwan

Ginsberg, MD,
director of Outpatient Services , Tisch Hospital Department of Psychiatry at
New York University Medical Center and section editor of MBL Communications,
Inc.
The supplement, entitled Optimizing Treatment of Schizophrenia: Enhancing
Affective/Cognitive and Depressive Functioning, includes a discussion of the
results of a new Harris Interactive(R) national consumer survey of people with
schizophrenia, which clearly illustrates the problem:

* 65% reported that, when making treatment decisions, their doctors place
"a great deal" of importance on positive symptoms while only 37% felt
their doctor places "a great deal" of importance on cognitive symptoms.

imcs duch

2005;10(2 Suppl 1):1-16). Schooler , PhD, adjunct professor of psychiatry at Georgetown
University School of Medicine, an author of the statement. In a large-scale study, patients who had not
responded well to prior treatment with risperidone , olanzapine, or
conventional antipsychotics were switched to ziprasidone, one of the newer
atypical antipsychotics, and showed statistically significant improvement in
cognitive symptoms.S.

Business Editors/Health/Medical Writers/Education Editors
BIOWIRE2K

CAMBRIDGE, Mass.
The Ipsen committee lauded Graybiel's pioneering basic research on
the basal ganglia, a poorly understood neuronal circuit connecting
several brain regions in the striatum.

bombay olap

com.

McGovern Institute's Ann Graybiel Wins Ibsen Foundation's 2005 Neuronal Plasticity Prize

dodgson olap

mblcommunications. Weiden, MD, professor of psychiatry and director
of the Schizophrenia Research Service at State University of New York (SUNY)
Downstate Medical Center in Brooklyn, an author of the statement.

duch refinement

A copy of the supplement can also be
accessed at http://www.
Not only do atypical antipsychotics differ in their ability to improve
cognition , they have different side effect profiles..

copernicus modal

"
While medications to treat schizophrenia's positive symptoms (such as
hallucinations, delusions, and disorganization) have existed since the
mid-20th century, newer medications introduced in the early 1990s, known as
atypical antipsychotics, also control the often overlooked symptoms of
depression, suicidal thoughts, and problems remembering or concentrating
(affective and cognitive symptoms). The survey found that virtually everyone with
schizophrenia (94%) believes that daily functioning is part of successful
treatment for schizophrenia and most (83%) believe with the right medications,
people with schizophrenia should be able to lead full lives.

callahan ajit

"Traditionally, physicians have been oriented to treating schizophrenia by
preventing symptoms from getting worse, rather than helping the person
continue to get better beyond their current level of symptoms and
functioning," said Peter J. is the independent publisher of the monthly
journals Primary Psychiatry and CNS Spectrums, as well as a host of enduring
material programs in conjunction with Mount Sinai School of Medicine.
She discovered a high degree of plasticity during habit and
procedure learning, and hypothesizes that the brain "chunks" the
separate pieces of the learning process together into a higher-order
representation that can be recalled as an entirety, without thinking,
as if on autopilot.

wlodzislaw callahan

, publishers of Primary Psychiatry and CNS Spectrums.

"These disorders are now implicated in a very wide
range of both neurological and psychiatric disease affecting millions
of Americans. Additional information
is available at: http://web.mit.

wavelets grained

Fortunately , at least two of the newer medications are not associated with
weight gain. CNS Spectrums - The
International Journal of Neuropsychiatric Medicine - is a monthly Index
Medicus/MEDLINE journal designed to bridge the clinical information needs of
48,000 US-based psychiatrists and neurologists . If you would like to learn
more about MBL Communications, Inc. please visit:
http://www.

neurofuzzy autostereoscopic

"The supplement and consensus statement were developed to encourage
physicians to address the debilitating effects of depression, cognitive
impairment and other aspects of the disease that dramatically impact the
quality of life for people with schizophrenia," said David L.

* Yet patients report that it is as important to control affective and
cognitive symptoms such as depression (77%), problems doing daily
activities (85%), and inability to focus/concentrate (81%), as it is to
control hallucinations and delusions (84%)."

About MBL Communications
MBL Communications, Inc.----Ann Graybiel, a
Principal Investigator at the McGovern Institute and Walter A.

coarse ajay

php3.

"Failure to control the affective and cognitive disease symptoms is one of
the biggest barriers preventing many patients today from achieving a
meaningful social and occupational recovery," said Philip D. "We believe
it is important for doctors to look beyond the control of positive symptoms
and consider the affective/cognitive benefits of medication to help patients
achieve a 'functional' recovery. No weighting was applied to these results, which have
a sampling error of +/- 10 percentage points. Source of survey: "Optimizing
Treatment in Schizophrenia Survey, November 2004." Awarded by the French
Fondation IPSEN pour la Recherche Therapeutique, the prize recognizes
researchers who shed light on the brain's plasticity, which refers to
its physical remodeling in response to experiences, learning, and
behavior. Graybiel's landmark discoveries about the critical role of
the basal ganglia in learning, motor control, and cognition are the
foundation of what will be a new era in therapeutic approaches to
basal ganglia disorders," says Robert Desimone , Director of the
McGovern Institute.

gianantonio refinement

Buckley, MD,
professor and chairman of the Department of Psychiatry and Behavioral Health
at the Medical College of Georgia, is also an author of the statement . Schizophrenia affects
approximately one in every 100 people.edu/mcgovern/

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concurrency refinement

."
Graybiel shares the 40,000 euros prize with Trevor Robbins and
Wolfram Schultz, both at the University of Cambridge, UK.

olap imcs

Common Schizophrenia Symptoms Often Overlooked By Physicians According To Expert Panel

"But we now
know that by taking a long-term focus and tackling a broader range of
symptoms , many patients do steadily improve so that they can function better,
and live fuller, more complete lives.

About the Survey
Harris Interactive(R) conducted the "Optimizing Treatment in Schizophrenia
Survey" online from October 27 - November 15, 2004, among 139 U. Primary
Psychiatry - The Leading Voice of Clinical Psychiatric Medicine - is the
largest circulation, peer-reviewed psychiatric journal in the United States,
with a monthly circulation of over 65,000 primary care physicians and
psychiatrists. Graybiel has found
that the basal ganglia also function in learning habitual actions and
procedures.
"Dr. Led by
a team of world-renowned, multi-disciplinary scientists , The McGovern
Institute was established in February 2000 by Lore Harp McGovern and
Patrick McGovern to meet one of the great challenges of modern science
- the development of a deep understanding of thought and emotion in
terms of their realization in the human brain.

logics imcs

---

- - kjjkjk

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