www. Its depositary receipts of shares are quoted on the
Euronext Amsterdam (WKL) and are included in the AEX and Euronext
100
indices.hofmann@wolterskluwer .

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ProVation Medical, Inc. The Company's core markets are spread across the
health, corporate services, financial services, tax, accounting,
law,
regulation, and education sectors.
"This is a highly creative, innovative partnership between a leading
clinical research organization and a leading medical school, bringing together
our individual skills and expertise," said William L. "We believe this
will serve as a model of how a CRO can help an academic medical center
increase its efficiency and capacity for effective clinical trials work, and
how a medical school can bring added value and expertise to a CRO.

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By
offering a choice of technologies, this enhanced version can work with
multiple platforms, operating systems, development tools and
relational databases. These
statements may be identified by words such as "expect", "should",
"could", "shall", and similar expressions.D.

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The DIB v2. "As the industry's most complete source
of current, clinically relevant drug information, this new version
will offer customers the ability to program files or data, which will
provide intelligence that helps medical professionals make better
clinical decisions."
DIB v2.

Amsterdam (January 4, 2006) - Wolters Kluwer, a leading
multinational publisher and information services company, today
announced plans to acquire ProVation Medical, Inc.
Hospitals
and Ambulatory Surgery Centers that use ProVation Medical software
(1) improve their coding accuracy resulting in a 5-25 percent
improvement in reimbursement for their medical procedures, (2)
eliminate transcription costs, and (3) consolidate and simplify
all
the major financial, clinical and administrative tasks that
accompany
each procedure.

Quintiles UNC-Chapel Hill Enter Clinical Research Alliance

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medi-span.
Driven
by deep medical content, ProVation MD, for example, allows
clinicians
to quickly and completely document medical procedures and apply
the
appropriate standard reimbursement codes.
"Working with UNC is important for Quintiles because it will provide real
benefits for our customers and for patients as well, and it also underscores
the innovative research going on at UNC," said Dennis Gillings, Ph. Drug development always
is working against the clock, and I believe this alliance will help us gain
precious days and weeks in getting new medicines to patients .

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The result is coder-
ready
documentation delivering compliance, proper reimbursement, and
shortened days in accounts receivable with a return on investment
ranging from 25-200% and payback within 12 -20 months.

The acquisition will be finalized in the next 30 days, pending
approval of ProVation Medical shareholders.

About Wolters Kluwer Health

Wolters Kluwer Health (Conshohocken , Pa. (Minneapolis, MN), a leading healthcare
software and services company, provides solutions that
significantly
enhance revenue and decrease costs per medical procedure.

Media
Connie Hofmann
Director of Communications Wolters Kluwer Health
+ 1 847 267 7153
connie.C., and the University of North Carolina at Chapel Hill today announced the
creation of a new alliance for clinical research.com .

pye winslow

1 Offers Medical Industry an Easy Way to Program Files or
Data and Gain Intelligence to Make Better Clinical Decisions

Wolters Kluwer Health, the leading drug information provider ,
today announced the launch of the .com. Today, UNC's School of Medicine maintains a position of
national leadership.

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"Wolters Kluwer Health, a leader in
the
clinical point of care market, recognized our accomplishments and
will acquire our company, creating value for our shareholders., Quintiles Inc.
The School's mission is to educate students and professionals of the health
and biomedical sciences, to conduct scholarly investigation in biomedical,
behavioral, and social sciences, and to render service to the people and
institutions of the state, the region , the nation, and, as appropriate,
throughout the world.

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1 is offered as a .1, please contact
Charles Conroy at www.

Forward-Looking Statements

This press release contains forward-looking statements.

About UNC School of Medicine
Established in 1879, UNC is the oldest medical school in North Carolina.

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Net application programming interface (API),
which can be easily linked to a healthcare organization's existing
drug information and clinical content, offering healthcare
professionals access to Medi-Span's popular family of drug information
databases. These tools aid in disease management, error reduction,
workflow improvements, and more effective patient management and are
used in thousands of hospitals, pharmacies, and physician offices.

In addition to these core ProVation offerings, the ProVation
platform
will enable Wolters Kluwer Health to further pursue its strategy
of
providing the healthcare market with embedded medical content and
workflow solutions at the point of care. In addition, financial risks, such as currency movements,
interest rate fluctuations, liquidity and credit risks could
influence future results.
Wolters Kluwer is a leading multinational publisher and
information
services company. The grant will help provide
new opportunities to patients to participate in clinical trials and gain
access to the latest experimental treatments available.quintiles.

prideaux winslow

1.) is a leading provider of
information for professionals and students in medicine, nursing,
allied health, pharmacy and the pharmaceutical industry. Major
brands
include Lippincott Williams & Wilkins and Facts & Comparisons for
medical and drug reference tools and textbooks; Ovid Technologies,
Medi-Span and SKOLAR for electronic information; and Adis
International and Source for pharmaceutical information.

News and media concerning the healthcare industry may include electronic or print publications.

pjb pjp

For additional information regarding DIB v2 .
Currently, the business unit includes the Medi-Span, Facts and
Comparisons, Clin-eguide and SKOLAR brands. Factors which could cause actual
results
to differ from these forward-looking statements may include,
without
limitation, general economic conditions, conditions in the markets
in
which Wolters Kluwer is engaged, behavior of customers, suppliers
and
competitors, technological developments, legal and regulatory
rules
affecting Wolters Kluwer's businesses and other risks and
uncertainties regarding the timing and closing of the transactions
described above, including the risk that the acquisition fails to
close. The foregoing list of factors should not
be
construed as exhaustive.com.

ProVation Medical, Inc.com

Caroline Wouters
Vice President, Corporate Communications Wolters Kluwer nv
+ 31 (0)20 6070 459
press@wolterskluwer. Headquartered near
Research Triangle Park, North Carolina, Quintiles has offices in 50 countries
and is the world 's leading pharmaceutical services organization.

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Wolters Kluwer Health Launches .Net Edition of Drug Information Bridge to Provide Access to Medi-Span Drug Database

Net edition of its Drug Information
Bridge (DIB) Version 2.4 billion."

ProVation Medical's 101 employees, including 10 physicians, will
become part of the Wolters Kluwer Health team, and will remain
based
in Minneapolis.com

Investors
Oya Yavuz
Vice President, Investor Relations Wolters Kluwer nv
+ 31 (0)20 6070 407
ir@wolterskluwer. "The clinical research unit will
help UNC and Quintiles conduct more clinical trials.

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To reduce application development expenses,
DIB v2. It is part of Wolters Kluwer
nv, Amsterdam , an international legal, tax, business, education and
health information services company with annual sales of more than EUR
3. Other major brands of
Wolters Kluwer Health include traditional publishers of medical and
drug reference tools and textbooks, such as Lippincott Williams +
Wilkins; electronic information providers, such as Ovid Technologies;
and pharmaceutical information provider Adis International . This privately-
held company provides medical documentation, coding and workflow
solutions to hospitals and ambulatory surgery centers in the
United States. Wolters Kluwer has annual
revenues
(2004) of EUR 3.provationmedical.,
Chairman and CEO of Quintiles Transnational.

standish pye

ProVation's multi-specialty software platform is the only product
in
today's marketplace that can provide proven return on investment
through clinical procedure documentation and coding compliance. Roper , M."
To help establish the clinical trial unit, Quintiles is providing a
$600,000 research grant over two years to UNC.

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With access to Medi-Span's drug descriptive data, prices,
image/imprint information and clinical data, this new version of DIB
will aid in streamlining the workflow process and increasing patient
safety.

Wolters Kluwer CEO and Chairman of the Executive Board Nancy
McKinstry said, "The addition of ProVation Medical to our health
portfolio is consistent with our strategy of entering adjacent
markets to support our commitment to growing our health business . "Our combined
capabilities will create one of the most comprehensive portfolios
of
medical content across the many points of care at a time when
organizations are looking to realize the full potential of their
investments in electronic medical records. Wolters Kluwer disclaims any intention or
obligation to update or revise these forward-looking statements,
whether as a result of new information, future events or
otherwise.com

Copyright Hugin ASA 2006.
Quintiles will provide Good Clinical Practice training for staff at the
clinical research unit. For more
information visit the company's Web site at http://www.

pye blueprints

The Clinical Tools business unit offers industry-leading
intellectual property, next-generation integrated drug and disease
databases and point-of-care information tools for healthcare
professionals.

ProVation's software suites for procedure documentation and coding
compliance replace the inefficient dictation/transcription
approach
and streamline the coding process to back-end coding reviews. These statements are
subject to risks and uncertainties, and actual results and events
could differ materially from what is contemplated by the
forward-looking statements., MPH, dean
of the UNC-CH School of Medicine and CEO of UNC Health Care.

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"

"Integration of ProVation's offerings with our current clinical
information tools will greatly strengthen our offerings to the
hospital and ambulatory surgery center markets," said Jeff
McCaulley,
Chief Executive Officer of Wolters Kluwer Health.
ProVation Medical will operate as a subsidiary of Wolters Kluwer
Health and continue to serve our customers with world class
products
and services.wolterskluwer.D.

About Quintiles
Quintiles helps improve healthcare worldwide by providing a broad range of
professional services, information and partnering solutions to the
pharmaceutical, biotechnology and healthcare industries. UNC is one of only a handful of leading medical schools
nationally both in funding for biomedical research and in the training of
primary care physicians.

privileges dorland

PRESS RELEASE Wolters Kluwer to Acquire ProVation Medical Inc.

"

"ProVation Medical, a private, venture capital backed company, has
worked very hard from its start -up phase in 1997 to define, create
and lead the clinical documentation market for hospitals and
ambulatory surgery centers," said Mark Wagner, Chief Executive
Officer, ProVation Medical. For more information , go to
www.
The alliance will give more patients and investigators access to clinical
research , help develop new clinical investigators, improve efficiency in the
clinical trial process, and allow Quintiles and UNC to collaborate on
industry-sponsored and federally sponsored clinical trials.

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Net edition, which works seamlessly with our existing
Medi-Span systems," says Ken Killion, CEO of Wolters Kluwer Health's
Clinical Tools business unit. ProVation
Medical will become part of Wolters Kluwer Health's Clinical Tools
unit, which provides embedded content tools to pharmacies,
hospitals,
insurers and healthcare vendors. All rights reserved.

ancc meniscus

"We are pleased to announce the release of the Drug Information
Bridge v2.1 .1 is integrated with the Medi-Span Foundation Library,
which allows customers to incorporate other Medi-Span API products
including Medication Order Management Database (MOMD), Drug Dosing and
Administration Database (DDAD) and Drug Facts + Comparisons (DFC ).wkhealth. Terms of the
acquisition
were not disclosed.

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Our world class employees will be retained and
highly
motivated to continue their pursuit of market penetration. This is
an
ideal outcome for ProVation Medical's customers, employees and
shareholders., the
North American clinical development subsidiary of Quintiles Transnational
Corp.

dorland blueprints

Business Editors/Health/Fitness Writers

PHILADELPHIA ----

DIB v2.com

Under the brand names of Medi-
Span,
Facts & Comparisons , and Clin-eguide, these tools provide
information
on drug interactions and dosing, formulary guidelines , and
evidence-based treatment plan options at the point of care.3 billion, employs approximately 18,400 people
worldwide
and maintains operations across Europe, North America and Asia
Pacific . For more information, see www.

About ProVation Medical, Inc. Goals include improving efficiency in drug development process

RESEARCH TRIANGLE PARK, N.

pye privileges

1 .Net edition offers users incremental updates
while also incorporating Facts and Comparisons reference information.com

About Wolters Kluwer Health-Clinical Tools business unit

Wolters Kluwer Health is a leading provider of information for
professionals and students in medicine, nursing, allied health,
pharmacy and the pharmaceutical industry., based in Minneapolis, provides software
solutions that streamline procedural documentation, while
improving
the accuracy of coding for accelerated revenue recovery .

reimbursement auscultation

Wolters Kluwer is headquartered in Amsterdam, the
Netherlands."
As part of the alliance, UNC will establish a clinical research unit that
will provide centralized support for clinical research at UNC-Chapel Hill.