Households will see the
strongest growth, as pet owners move towards do -it-yourself animal care.
United States sales of pet supplies, consisting of items such as dog and cat
toys, collars and leashes, cages and habitats, books, vitamins and
supplements, shampoos, flea and tick control, and aquatic supplies, were
quantitated.
Antech Diagnostics
BASF Agricultural Products and Nutrition
Bayer Animal Health
Boehringer Ingelheim Corp. When a catheter becomes occluded,
the goal is to restore flow in a prompt and cost-effective manner with minimal
risk to the patient.S.
Information about Nuvelo is available at our website at http: //www.

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- Focus on global industry development through an in-depth analysis of the
major world markets for animal health, including forecasts for growth.3 mg/kg of alfimeprase with placebo in a total of 600
patients. The second trial, NAPA-3, is expected to begin in early 2006 and is
being conducted under a special protocol assessment from the FDA.

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- Discover feasible market opportunities via an identification of high-
growth applications in different animal health areas, with a focus on the
biggest and expanding markets. The total market for health care products of all
kinds is an important part of the pharmaceutical market, and is described in
detail. Feed additives sales are
also detailed in the report. Two-thirds of the participants are receiving
alfimeprase and the remainder are receiving placebo. Food and Drug Administration (FDA) for the NAPA
program . The first trial in this
program, NAPA-2, is expected to complete enrollment in the second half of this
year.

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It focuses primarily on the animal
health segment, and, separately, on a description of the medicinals and
supplies marketed by major companies in this segment the veterinary health
market.
Laboklin
Medigenomix GMBH
Optigen
PE AgGen/ Celera AgGen
Synbiotics
Prokaryon
Microbix
Dow AgroSciences LLC
Abbott Laboratories
Adisseo SAS
Akzo Nobel NV
Aventis SA
Colgate-Palmolive Company
Colorado Veterinary Products
Degussa AG
King Pharmaceuticals Incorporated
MVP Laboratories Incorporated
Nestle SA
Novus International Incorporated
Philipp Brothers Chemicals Incorporated
Procter + Gamble Company
Veterinary Products
Texas Vet Lab Incorporated
Kyowa Hakko
Nippon Zenyaku
Vetoquinol

For more information visit
http: //www. Such statements are based on our management's current expectations and
involve risks and uncertainties . These and other
factors are identified and described in more detail in Nuvelo filings with the
SEC, including without limitation Nuvelo's recent annual report on Form 10-K
for the year ended December 31, 2004 and subsequent filings.

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newscom.
Veterinarians will remain the primary end user of animal health chemicals
due to the prescription-only nature of many products and their expertise in
diagnosis and treatment. Recent growth in
all segments of the pet industry has provided an opportunity for both existing
players and new entrants.
Virbac SA
Petco
PetsMart
Adiagene
Antech Diagnostics
Avian Biotech
BioBest
BioVet
Cypress Diagnostics
DayMoon Industries
Dupont Qualicon
Dr.
GeneCheck
Gene -Trak
Heska
Igen International, Inc.g." The
program consists of two overlapping, randomized , double-blind, multi-national
trials comparing 0. Under the terms of
the agreement, BHC will commercialize alfimeprase in all territories outside
the United States and will pay Nuvelo tiered royalties ranging from 15 to 37. Nuvelo retains commercialization rights in the United States, has
received a $50 million up front payment and is eligible to receive an
additional $335 million in milestone payments from BHC.nuvelo.

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com/reports/c14800) has announced the addition
of Veterinary Health Markets to their offering. This
report describes the worldwide market for animal health products, which
consists health care products for domestic companion animals, livestock and
co-marketed consumables. However, veterinarians will face increasing
competition from over-the -counter outlets such as pet supply stores and the
Internet, which enable pet owners, farmers and animal managers at other sites
to purchase animal health chemicals at a lower price.
Veterinary Centers of America, Inc. "We look forward to completing
the first trial in this program, SONOMA -2, later this year and expect the
Phase 3 trial results to confirm the ability of alfimeprase to restore
function to occluded catheters in 15 minutes or less, as demonstrated in our
Phase 2 trial . Alfimeprase also restored flow to 60 percent of occluded
catheters at 120 minutes after the first dose and to 80 percent of occluded
catheters at 120 minutes after the second dose compared with 46 percent at 120
minutes after the first dose and 62 percent at 120 minutes after the second
dose with Cathflo(R)Activase(R).com or
by phoning 650-517-8000.

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researchandmarkets.
Livestock and poultry will continue to account for the majority of animal
health chemical demand. As these catheters are primarily inserted in patients
receiving life-saving medications such as chemotherapy, it is critical to
restore flow through the catheter as soon as possible. In the case of
thrombotic occlusions, treatment with thrombolytic drugs represents a
less-invasive and more cost-effective alternative to replacement.

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Examining both
the livestock and companion animal markets, this report describes advances and
changes in:
- The regulatory environment
- Biological products
- Pharmaceutical products
- Animal health diagnostic products
- Emerging biotechnology products. The pet
product industry serves a large and growing market.
This open-label, single -arm trial will evaluate the safety and efficacy of 3
mg of alfimeprase in 800 patients with occluded central venous catheters.D. Currently,
Cathflo(R)Activase(R) is approved in the United States for restoring function
to central venous catheters. Nuvelo's development pipeline includes
three acute cardiovascular programs focused on alfimeprase, a direct-acting
thrombolytic in Phase 3 clinical trials for the treatment of
thrombotic-related disorders; rNAPc2, an anticoagulant that inhibits the
factor VIIa and tissue factor protease complex that is currently in Phase 2
clinical development for acute coronary syndrome and a thrombin inhibiting
aptamer for anticoagulation during medical procedures.

Pet health products include medications ( such as worming medicine or flea preventives ) which do not require a veterinarian, and items to assist in recovery or disability at home ( such as splints or incontinence pads ).

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, and other countries of the big five.v."
Previously announced results from a Phase 2 multi-center, randomized,
double-blind study in 55 patients with occluded central venous catheters
demonstrated that alfimeprase restored flow to 40 percent and 50 percent of
occluded catheters 5 and 15 minutes after the first dose, respectively. is dedicated to improving the lives of patients through the
discovery, development and commercialization of novel drugs for acute
cardiovascular and cancer therapy. We disclaim any
intent or obligation to update these forward-looking statements.

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Approximately 5
million catheters are placed in patients in the United States each year, with
as many as 25 percent becoming occluded. In
clinical studies to date, alfimeprase has been shown to have the ability to
resolve peripheral arterial (e. Fast track designation is reserved for new drugs that demonstrate
the potential to address an unmet medical need and are intended for the
treatment of a serious or life-threatening condition.

About Nuvelo
Nuvelo, Inc. Actual results and performance could differ
materially from those projected in the forward looking statements as a result
of many factors, including, without limitation, uncertainties relating to drug
discovery; clinical development processes; enrollment rates for patients in
our clinical trials; changes in relationships with strategic partners and
dependence upon strategic partners for the performance of critical activities
under collaborative agreements; the impact of competitive products and
technological changes; uncertainties relating to patent protection and
uncertainties relating to our ability to obtain funding.

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economy.
The ownership of pets is widespread, with over 58% of U. The market for pet and
equine products and supplies, including services, is evaluated in this report. Sales for products used in livestock and poultry are totalled, while
companion animal health product sales are compared.

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However, companion animals will continue to see the
fastest growth , driven by strong growth in product developments, general aging
in the pet population and increased spending per animal.com
Fax: +353 1 4100 980

Nuvelo and Bayer HealthCare Begin SONOMA -3 Second Phase 3 Trial of Alfimeprase in Patients With Central Venous Catheter Occlusion

and LEVERKUSEN , Germany, Nuvelo Inc. A variety of secondary endpoints are
also being evaluated, including safety endpoints such as the incidence of
bleeding, and pharmacoeconomic endpoints such as length of hospital and
intensive care unit (ICU) stay.

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K.
Nutritional chemicals, the largest class of animal health products, will
see above average growth due to interest in improving food animal quality, in
aiding disease prevention and improving waste management. The primary endpoint is
restoration of catheter function within 15 minutes. The primary endpoint in both trials is avoidance of open vascular
surgery within 30 days of treatment.

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Research and Markets: Demand for Animal Health Chemicals in the US Forecast to Grow to More Than $8 Billion in 2006

Based on information gained from data collected from interviews with
senior managers, as well as other primary sources, Veterinary Health Markets
analyzes incidence and demographics to help define market potential, and
scrutinizes other forces and dynamics to predict the shape of this market for
years to come.S.

About Alfimeprase
Alfimeprase is an enzyme produced by recombinant DNA technology that
rapidly resolves blood clots through a unique mechanism of action; it directly
degrades fibrin, a protein that provides the scaffolding for blood clots.

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Demand for animal health chemicals in the US is forecast to advance four
percent per year to more than $8 billion in 2006, supported by the continuing
emergence and threat of animal disease, changes in animal production
practices, new product introductions and ongoing food safety concerns. SAN CARLOS, Calif.

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Van Haeringen Laboratorium b.researchandmarkets.

About Catheter Occlusion
Delivery of chemotherapy, nutritional support, antibiotics and blood
products, as well as the frequent withdrawal of blood samples for laboratory
testing, are often facilitated via central venous catheters.

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Company Profiles

Alpharma Inc.
Deitcher, M. In addition ,
its lytic activity is localized to the site of delivery due to its rapid
inhibition by alpha -2 macroglobulin, a naturally occurring protein in the
blood, as soon as it moves away from the clot and into the general
circulation.

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com/cgi-bin/prnh/20040820/RESEARCH )
This report offers a broad yet detailed overview of the shape of the
veterinary health products market over the next several years. The report discusses the market size, growth rates, and market
components for medical each of the major categories of veterinary supplies.
The pet industry is a major segment of the U . (Nasdaq: NUVO) and Bayer HealthCare
(BHC) today announced that they have begun patient enrollment in a second
pivotal Phase 3 clinical trial of lead product candidate, alfimeprase, for the
treatment of central venous catheter occlusion (CO).
The Phase 3 trial, known as SONOMA-3 (Speedy Opening of Non-functional and
Occluded catheters with Mini-dose Alfimeprase-3), is the second of two
overlapping , multi-national trials in the Phase 3 alfimeprase program for CO. This randomized, double-blind study is comparing the
efficacy of 3 mg of alfimeprase with placebo in 300 patients with occluded
central venous catheters. In addition, Nuvelo
expects to leverage its expertise in secreted proteins and cancer antibody
discovery to further expand its pipeline and create additional partnering and
licensing opportunities.

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Parasiticides, the
second largest class of animal health chemicals, will see the fastest gains as
a result of product developments for the companion animal market, such as
those aimed at treating more than one pest in a single product, and the
increasing availability of parasite control products for pet owners through
retail outlets and the Internet. The Companion Animal Health segment includes
diagnostic and monitoring instruments and supplies as well as single use
diagnostic tests , vaccines and pharmaceuticals, primarily for canine and
feline use.com/reports/c14800

Laura Wood
Senior Manager
Research and Markets
press@researchandmarkets.

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DUBLIN, Ireland, Research and Markets
(http://www.

The report surveys the market dynamics and technological trends to answer
several basic, but essential, questions about this market:

- How will changes in the regulatory environment (e., Japan and Europe, including Germany, the
U.

Additional Clinical Trials
The first study in the ongoing Phase 3 clinical program in CO, SONOMA-2,
began in September 2005 and is expected to complete enrollment in the second
half of this year.

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g.
"We believe that alfimeprase has the potential to quickly dissolve clots
and rapidly restore the ability to infuse critical therapy such as
chemotherapy or antibiotics through once occluded catheters," said Steven R.

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, VICH) affect you?
- How will closer regulation of hormones and antibiotics in feed impact
the livestock markets?
- How are changes in meat consumption influencing the market for
livestock health products?
- What new companion animal vaccines are coming to market?

This report seeks to:

- Identify viable technology drivers through a comprehensive look at
various compounds for animal health , including companion animals and
veterinary medicine, as well as commercially important livestock animals.S.
Animal health product sales in the United States are summarized in this
report . This clearance mechanism helps focus the thrombolytic activity
to the site of delivery and, in clinical testing, appears to minimize bleeding
side effects.

This press release contains "forward-looking statements" regarding the
timing and progress of Nuvelo's alfimeprase clinical programs , the potential
improvement or benefit that current and future clinical trial programs may
demonstrate , the potential for regulatory approval for alfimeprase, and the
numbers of patients who may be eligible for treatment by alfimeprase, which
statements are hereby identified as "forward-looking statements " for purposes
of the safe harbor provided by the Private Securities Litigation Reform Act of
1995 .

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By
comparison, Cathflo(R)Activase(R) (alteplase) did not restore flow at either
time point. leg ) clots within four hours of initiation
of dosing and to clear occluded catheters in 15 minutes or less.

About the Collaboration
In January 2006, a global collaboration was formed between Nuvelo and BHC
for the development and commercialization of alfimeprase.

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(Logo: http:/ /www.

This report concentrates on the supplies, supplements and consumables used
in this area the veterinary health market segment including important
worldwide markets such as the U., vice president of medical sciences for Nuvelo and former
principal investigator of the Phase 2 trial.

In addition, Nuvelo recently announced plans to initiate a Phase 2 trial
of alfimeprase for the treatment of ischemic stroke in the second half of
2006, and a Phase 2 trial of alfimeprase for the treatment of deep venous
thrombosis in 2007.

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S. households
owning at least one pet, including companion and other animals.
Elanco Animal Health
Fort Dodge Animal Health (Wyeth)
Heska Animal Health
IDEXX Laboratories
Intervet International
Merial Animal Health
Monsanto
Novartis Animal Health
Pfizer Animal Health
Roche Animal Nutrition and Health
Rhone-Poulenc SA CVC Aventis Animal Nutrition
IMG Global, Inc
Schering-Plough Animal Health
Synbiotics Corp.
Alfimeprase is also being studied in an ongoing Phase 3 program known as
the NAPA (Novel Arterial Perfusion with Alfimeprase) program , for the
treatment of acute peripheral arterial occlusion (PAO), or "leg attack. In January 2006 , Nuvelo received fast track
designation from the U.5
percent. In addition, BHC will
be responsible for 40 percent of the costs for global development programs and
Nuvelo will be responsible for 60 percent of the costs and will remain the
lead for the design and conduct of the global development programs. Nuvelo is also
progressing an emerging oncology pipeline, which includes NU206, for the
potential treatment of chemotherapy/radiation therapy-induced mucositis, as
well as rNAPc2 for potential use as a cancer therapy.

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