Hyun Bae, M. A larger, prospective randomized controlled
multi -center IDE study is underway in the U. Our longer-term U.

REMINDER/The Press Club of Cleveland Presents ``Food Factor: The Art and Business of Writing About Food'' and ``Thirsty Thursday''

Gail is an author of three books, most recently
Cleveland Food Memories

Joe Crea - Food and Restaurants Editor, The Plain Dealer

Moderator:

-- Crickett Karson - Lief + Karson Communications

Hear local food authorities tell you how they do what they do.

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at The Spine Institute at Saint John's Health
Center, Santa Monica, CA, led the study. The study results appear to be consistent with the
results obtained in the prospective vertebroplasty study using Cortoss
conducted in Europe .S.4cc per
vertebra treated. Bae.S. Please call 440.899.1222 or email
lbprscleve@aol.

arts biography

and Raymond
Linovitz, M.D."

About the Company

Orthovita is a leading biomaterials company with proprietary
technologies for the development and commercialization of synthetic,
biologically active, tissue engineering products for orthopedic and
neurosurgical applications. Factors that may cause such a difference
include, but are not limited to, our dependence on the commercial
success of our approved products, our history of operating losses and
our need for additional funds, our need to obtain and maintain
regulatory approvals to sell our products, the rate at which we invest
in our field sales network, the ability of our field sales network to
generate new sales, our ability to manage commercial scale
manufacturing capability and capacity, risks and uncertainties in
pre-clinical and clinical trial results, market acceptance of our
products, the sales levels of our products, our success in expanding
our commercial product portfolio and distribution channel , research
and development, competition and other risk factors listed from time
to time in reports filed by the Company with the U.

arts presents

D. "A larger,
prospective randomized controlled IDE study to confirm these findings
in under way.for The Press Club of
Cleveland's Leadership Series will present a panel discussion "Food
Factor: The Art and Business of Writing About Food" on Monday,
February 7 at the City Club, 850 Euclid Avenue in downtown Cleveland.com to register. to enjoy drink specials , appetizers and the ambiance
of downtown's newly-renovated East 4th Street.

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Orthovita Reports Cortoss Vertebroplasty Data to be Presented at the American Academy of Orthopedic Surgeons

from Wednesday , February 23, 2005 through Friday, February 25,
2005., at CORE Orthopedic Medical Center in Encinitas , CA.12cc as measured on post-op CT scans.
clinical development program is focused on our Cortoss (R) Synthetic
Cortical Bone technology platform, which is designed for injections in
osteoporotic spines to treat vertebral compression fractures. Securities and
Exchange Commission (SEC), including but not limited to risks
described in our most recently filed Form 10-K under the caption
"Certain Risks Related to Our Business". Press Club members $20; non-members
$30.

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D., CCP - Managing Editor and Food Editor of
Restaurant Hospitality, a national magazine for the restaurant
industry.

arts literature

D.9cc
per vertebra treated, with the volume ranging from 0. Due to the engineered radiopacity of Cortoss,
extravasations were easily detected intra-operatively and averaged
0. All extravasations were
anatomically close to the vertebra and remained asymptomatic, with no
cardiac or pulmonary emboli observed," said Dr., to develop and market novel synthetic-based
biomaterial products, and continues to pursue similar relationships
with other companies in biomaterials.

This press release contains forward-looking statements regarding
Orthovita's current expectations of future events that involve risks
and uncertainties, including, without limitations, our products and
other aspects of our business.
Panelists include:

Laura Taxel - freelance journalist with Cleveland Magazine,
Northern Ohio Live, Plain Dealer and Continental and author of
Cleveland Ethnic Eats

Gail Bellamy, Ph. We hope to
see you at 6 p.

academy american

The study results
seemed to suggest that a relatively small volume of Cortoss may be
able to reinforce the vertebrae and achieve symptomatic relief, as
compared to the larger volumes reported in the literature for
polymethylmethacrylate (PMMA) bone cement. designed to demonstrate
that Cortoss is safe and effective for the treatment of osteoporotic
vertebral compression fractures.

Business Editors
REMINDER.
Registration will begin at 11:30 a.m.

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, Timothy Peppers, M. Lunch and the panel discussion included.
Books will be available for sale and can be signed by the authors.m.

photograph poets

(NASDAQ NM:VITA), a leading developer of
orthopedic biomaterials, today reported that a poster titled "A
Prospective Multi-Center Pilot IDE Study on the use of Cortoss in
Vertebroplasty - Report on the First 20 Cases" will be exhibited at
the American Academy of Orthopedic Surgeons being held in Washington,
D. Such statements are based on
management's current expectations and are subject to a number of
substantial risks and uncertainties that could cause actual results or
timeliness to differ materially from those addressed in the
forward -looking statements.
Learn what to expect, what's the criteria, and how to pitch your
restaurant or food story. Bring your friends and
co-workers - the more, the merrier! Cash bar.

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D. Our near-term commercial business is based on
our Vitoss(R) Bone Graft Substitute technology platforms, which are
designed to address the non-structural bone graft market by offering
synthetic alternatives to the use of autograft or cadaver-derived bone
material to meet a broad range of orthopedic clinical needs in the
spine, trauma, joint reconstruction, revision surgery and extremities
markets, and Vitagel(TM) Surgical Hemostat, which is a safe adherent
matrix and an impermeable barrier to blood flow..

Press Club "Thirsty Thursday" Event - February 10, 2005

Take a break from the winter blues and join us for the Press
Club's first Thirsty Thursday of 2005 on February 10 at the hottest
new spot in Cleveland - the House of Blues, Cambridge Room.

literature photograph

----

A Prospective Multi-Center Pilot IDE Study on the Use of Cortoss
in Vertebroplasty
- Report on the First 20 Cases at Twelve Months -

Orthovita, Inc. at the Pennsylvania Hospital in Philadelphia, PA,
as well as Erik Westerlund, M.D. Cortoss appeared to have an
interdigitated fill pattern, which is intended to create trabecular
reinforcement.7cc to 4. Our products are used in the regeneration
of bone and soft tissue.
Orthovita works jointly with Kensey Nash Corporation and Angiotech
Pharmaceuticals, Inc .

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Business Editors/Health/Medical Writers
American Academy of Orthopedic Surgeons

MALVERN, Pa.C.
The pilot IDE study was intended to provide preliminary
information about the use of Cortoss(R) Synthetic Cortical Bone to
treat osteoporotic vertebral compression fractures .
"In this study, the average volume of Cortoss injected was 1. Orthovita undertakes no obligation to
publicly update any forward-looking statements..

academy american

Other investigators included
Philip Maurer , M.S. Further information about
these and other relevant risks and uncertainties may be found in
Orthovita's filings with the SEC, all of which are available from the
SEC as well as other sources ., lunch will be served at noon
and the presentation will begin at approximately 12:30, followed by a
Q + A session.
Pre-registration is required.

american presents

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