"I believe it is important for a binder to trap dietary phosphorus in the
acidic environment of the stomach and duodenum, before it can be absorbed in
the small intestine."
Without effective treatment, hyperphosphatemia (high levels of phosphorus
in the blood) can lead to renal osteodystrophy in end stage renal disease
(ESRD) patients, and an increased risk of bone pain, skeletal deformities and
fractures. Such binders "soak up" phosphorus in the
gastrointestinal tract, before it can be absorbed into the blood. Despite the
availability of these agents, it remains a challenge for some ESRD patients to
maintain target ranges. Other side effects
reported in trials included dialysis graft complications, headache, abdominal
pain and hypotension.

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In addition, the
presence of bile acids did not affect the stability of the
FOSRENOL (R)/phosphate complex, whereas bile acids led to a more than 20-fold
reduction in phosphate-binding affinity of sevelamer HCl with the consequent
release of its phosphate.5
mg/dL, the blood phosphorus levels of many patients on dialysis exceed 6. Shire has operations in the world's key pharmaceutical markets
(U. Further, because the putative binding sites
were mapped across the entire genome as opposed to pre-selected sequences, the
likelihood of discovering new sites and novel genes was higher . Genpathway has developed two analysis modes for use with
FactorPath(TM): QueryMode(TM) analysis results in quantitative information
about the level of binding for any DNA-associated factor to any site in the
genome, and DiscoveryMode(TM) analysis scans across the genome to identify
sequences bound by the transcription factor or coregulating factor of
interest.com, for Genpathway, Inc.jamesgames .

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WASHINGTON, Data presented today at the
National Kidney Foundation (NKF) 2005 clinical meeting in Washington, D.
"The comprehensive data were thoroughly evaluated on several parameters
over a number of years," said Ghodrat Siami, M.
Most patients require a total daily dose between 1,500 mg and 3,000 mg to
achieve serum phosphorus control, which equates to one to two FOSRENOL(R)
tablets per meal. This factor is believed to boost the
cancer cells' selective growth advantage over normal cells.

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,
showed that, in vitro, FOSRENOL(R) (lanthanum carbonate) binds phosphate
across a broad pH range with higher affinity than sevelamer hydrochloride.

Managing Hyperphosphatemia
Phosphorus, an element found in nearly all foods, is absorbed from the
gastrointestinal tract into the bloodstream.

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In addition to the binding affinity data, another study presented at the
NKF clinical meeting found that FOSRENOL(R) continued to demonstrate sustained
efficacy, tolerability and safety in patients (n=33) treated for up to five
years. The most
common side effects leading to discontinuation in clinical trials were
gastrointestinal events (nausea, vomiting, and diarrhea ).
Patients with acute peptic ulcer, ulcerative colitis, Crohn's disease or bowel
obstruction were not included in FOSRENOL(R) clinical studies. FOSRENOL(R) should not be taken if
you're nursing or pregnant.

Shire Pharmaceuticals Group plc
Shire Pharmaceuticals Group plc (Shire ) is a global specialty
pharmaceutical company with a strategic focus on meeting the needs of the
specialist physician and currently has a range of projects and products in the
areas of central nervous system (CNS), gastrointestinal (GI), and renal
disease. When SRC-3 binds to ER in breast cancer
cells, the combination either activates or represses transcription of the
affected genes , leading to other changes important in the disease. Using
Genpathway's FactorPath(TM) assay in DiscoveryMode (TM), the researchers
identified binding of SRC-3 to hundreds of previously undescribed genomic
sites . The
investigators then applied a second assay, Genpathway's TranscriptionPath(TM)
QueryMode(TM ), to show that the genes in the vicinity of the new SRC-3/ER
binding sites were indeed changed in their expression levels as a result of
stimulation with estrogen.
"Graduation is a high point in people's lives, and young men and women
will look back on the events and experiences that helped shape who they are,"
Oppenheim said. For the most professional-looking
results and to avoid problems of adhesive labels, it is best to use inkjet
printable CDs and DVDs and a printer capable of printing directly onto the
media.
The home movies and photo collections that you create can be combined with
scrapbooks and any other memorabilia you or your graduate may have gathered
over the years .

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5
mg/dL.com. Further study was then done with FactorPath(TM) QueryMode(TM),
Genpathway's second analysis mode., chairman of the
Department of Molecular and Cellular Biology at Baylor College of Medicine,
and a coauthor on the study.

About FactorPath(TM)
FactorPath(TM) is a component of Genpathway's integrated suite of novel
and proprietary transcription-based assays that measure the process of gene
transcription directly, rather than accumulated RNA levels. http://www .genpathway. The EPSON StoryTeller Photo Book Creator is an all-inclusive kit
offering an easy and professional way to turn individual photos into a
beautiful, hardbound, glossy photo book that can be printed and assembled
right at home. EPSON StoryTeller Photo Book Creator kits are available
beginning at $19. Offering ease-of-use and
better image quality than ever before, digital cameras provide users the
flexibility to take photos, view them and delete them if they aren't just
right , as well as make it easy to create an archival print to cherish for
years to come.
Convert your 35mm slides or VHS tapes into digital form and burn them onto
recordable media, such as CDs and DVDs .

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Stephen
Damment, Senior Vice President of Biosciences R+D, Shire, UK.D., Ph.
The recommended initial daily dose of FOSRENOL(R) is 750-1,500 mg for adults;
physicians should adjust the dose to reach target serum phosphorus levels.D.

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, professor of
medicine at Vanderbilt University and assistant chief of the nephrology
medical service at the Veterans Administration Medical Center in Nashville,
TN.S.com.

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C.
The phosphate-binding affinity of FOSRENOL(R) was more than 200 times
higher compared to sevelamer HCl at pH 3, which simulates the acidic
environment of the stomach.
Even with a low phosphorus diet, most ESRD patients in the U. When the kidneys fail , they no
longer effectively remove phosphorus, even with the help of blood-cleansing
dialysis machines. According to the K/DOQI Clinical Practice Guidelines
for Bone Metabolism and Disease, Guideline 3, Evaluation of Serum Phosphorus
Levels, fewer than 30 percent of dialysis patients are able to maintain serum
phosphorus levels in the target range. "Genpathway's new assays enabled us to rapidly
identify a number of strong binding sites of SRC-3. Noted family technology
expert James Oppenheim provides three gift ideas to help make that perfect
keepsake for this year's graduation day.

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The most common adverse events were gastrointestinal, such as nausea and
vomiting, and generally abated over time with continued dosing.D. "This study
demonstrates the ability of FactorPath (TM) to identify the genomic regions
functionally bound by a specific transcription factor or coregulating factor
in living cells, and to quantify the binding levels., Some of the most cherished
gifts to help graduates commemorate this milestone in their lives might not be
found in a store. "There is no better way to ensure those precious memories
will be preserved for years to come than to either give personalized gifts to
relive the special events leading up to or on that important day or to give
graduates the tools that enable them to preserve their future memories for
themselves.

Capturing and Preserving Memories
Today, it is easier than ever to capture special moments using a digital
camera, and you don't need to be a technology expert to do it.

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Caution should
be used in patients with these conditions. - Study Published in Proceedings of the National Academy of Sciences
Describes New Methods for Identifying Genes Regulated by
Coactivator -Transcription Factor Combination Important in Breast Cancer -

- Innovative Assays Offer Advantages for Discovering Drug Targets and
Biomarkers in Breast Cancer, Other Cancers, and Other Diseases -

SAN DIEGO, Researchers at Genpathway, Inc.com/storyteller.

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When assessed at pH 5 to 7 , the affinity of
FOSRENOL(R) was four-fold higher compared to sevelamer HCl.

ABOUT FOSRENOL (R)
FOSRENOL(R) is indicated to reduce serum phosphate. FOSRENOL(R), which
received FDA approval in October 2004, is formulated as an easy to use,
chewable only tablet that can be taken without water, an important advantage
for ESRD patients who must restrict their fluid intake.99. Using a small bookshelf, or even a large photo box, build a
personal "memory library" that can be visited to relive special occasions at a
moment's notice.com.

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In addition, FOSRENOL(R)-treated patients maintained serum
phosphorus reductions for up to five years.S. For further information on Shire , please visit
the Shire Web site: http://www. For further information about
FOSRENOL(R), please visit the FOSRENOL(R) Web site at http://www., CEO of Genpathway."
The research was funded by the National Institutes of Health, the Welch
Foundation, and the Susan G.

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In fact, by the fifth year no patients reported treatment-related
adverse events. Such levels have been linked to a significantly higher illness and
death risk for patients who have undergone at least one year of dialysis. FOSRENOL (R) should not be taken if you are under
18 years of age.

ABOUT GENPATHWAY, INC.

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will
develop hyperphosphatemia and therefore require a phosphate-binding drug. FOSRENOL(R)
does not contain calcium or aluminum; it meets the K/DOQI recommendations as
one of the preferred first-line treatment options in lowering serum phosphorus
levels. FOSRENOL(R) launched
in January 2005 and is available in 250 milligram (mg) and 500 mg strengths. The daily dose should be divided and taken with meals.S. Family Technology Expert James Oppenheim Shares Fun and
Memorable Gift Ideas for Your Favorite Graduate

LONG BEACH, Calif."
Oppenheim suggests memorable gift ideas made with a variety of digital
imaging tools and techniques to make graduation day one-of-a-kind with
personalized keepsakes:

A Graduation Day Bestseller
Most people take pictures to document the events throughout their
graduate's school years: group outings, school activities , birthday parties,
and more. More information is available at
http://www.

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The K/DOQI Clinical Practice Guidelines for Bone Metabolism and Disease
also note in Guideline 5, Use of Phosphate Binders in Chronic Kidney Disease
(CKD), that non-calcium and non-aluminum phosphate binders are a preferred
first-line treatment option in lowering serum phosphorus levels."
The Genpathway-Baylor paper , published in the February 1 issue of
Proceedings of the National Academy of Sciences, is entitled , "Identification
of Target Genes in Breast Cancer Cells Directly Regulated by the SRC-3/AIB1
Coactivator .
Genpathway is a systems biology company developing innovative assays that
identify and analyze gene expression mechanisms and their biological pathways
to drive discovery and testing of novel pharmaceuticals, biomarkers, and
diagnostic tests. They are the gifts of memories. Then the digital images can easily be printed for display in
picture frames or portrayed in story form through a personal hardcover photo
book.epson.

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THE "SAFE HARBOR" STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM
ACT OF 1995
Statements included herein that are not historical facts are forward-
looking statements. and
Baylor College of Medicine in Houston have applied a new suite of integrated
transcription -based assays to identify novel genes important in breast cancer. SRC-3 regulates
genes by interacting with certain nuclear hormone receptors such as estrogen
receptor (ER), a transcription factor that can turn the expression of specific
genes up and down or on and off. The method was then
extended to identify a subset of genes with binding by both SRC-3 and the
estrogen receptor.com

CONTACT: Mary Moynihan of M2Friend Communications, +1-802-951-9600,
mary@m2friend.
For more information about the latest consumer technology products
available for families, visit http://www .

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FOSRENOL(R) is marketed by Shire Pharmaceuticals Group plc (LSE: SHP,
Nasdaq: SHPGY, TSX: SHQ ). Although studies were not designed to detect
differences in risk of fracture and mortality, there were no differences
demonstrated in patients treated with FOSRENOL(R) compared to alternative
therapy for up to three years., Canada, UK, France, Italy, Spain and Germany) as well as a specialist
drug delivery unit in the U. Further analysis confirmed the involvement
of both the coactivator and the transcription factor, and a second Genpathway
assay, TranscriptionPath(TM), provided additional evidence that these genes
are biologically relevant.

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The duration of treatment exposure and time of
observation in the clinical program are too short to conclude that FOSRENOL(R)
does not affect the risk of fracture or mortality beyond three years.shire.

Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer Using Genpathway's Novel Transcription-Based Assays

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In an initial analysis of 29 of these
sites, 18 were determined to be strong binding sites for SRC-3."
"Because only a fraction of potential binding sites are actually used
inside cells, the ability to zero in on the functional sites in a genome is
critical," said Benjamin Monderer, Ph. Komen Breast Cancer Foundation.

These cherished images can be presented to the graduate to reawaken
the significant feelings experienced during those events.

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Accumulating evidence also shows that hyperphosphatemia may
contribute to cardiovascular disease, which accounts for almost half of all
deaths among dialysis patients.

5 to 4. The risks and uncertainties include, but are not limited to, risks
associated with the inherent uncertainty of pharmaceutical research, product
development, manufacturing and commercialization , the impact of competitive
products, including, but not limited to, the impact on Shire's Attention
Deficit + Hyperactivity Disorder (ADHD) franchise, patents, including but not
limited to, legal challenges relating to Shire's ADHD franchise, government
regulation and approval, including but not limited to the expected product
approval dates of METHYPATCH(R) (methylphenidate), XAGRID(R) (anagrelide
hydrochloride) and BIPOTROL(R) (carbamazepine), the implementation of Shire's
planned reorganization and other risks and uncertainties detailed from time to
time in Shire's filings with the Securities and Exchange Commission, including
Shire's most recent annual report on Form 10-K .
"Because coactivators such as SRC-3 do not bind DNA directly, extensive
work is usually required to distinguish which differentially expressed genes
identified by other methods, such as RNA profiling , are either direct or
indirect transcriptional targets," said Bert O'Malley, M. If those photos
aren't already digital they can be scanned, and the faded colors in old photos
can be restored .

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As patients continued on therapy, the number of adverse events
decreased. While the normal adult range for phosphorus is 2.
Of the approximately 20 million Americans who have some form of kidney
disease, as of 2002, more than 512,000 have developed ESRD, a figure that has
grown 400 percent over the last 20 years.FOSRENOL. In the event such
risks or uncertainties materialize, Shire's results could be materially
affected.

FactorPath(TM)
identifies genomic DNA sequences that are functionally associated with a
particular transcription factor or coregulator in a cell population . The assay
also quantifies the binding level of each factor across the genome in any cell
sample .

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"Based on the results reported, we're able to further reinforce the
safety and efficacy profile for FOSRENOL(R).
However, control of serum phosphorus to the National Kidney Foundation's new
Kidney Disease Outcomes Quality Initiative (K/DOQI) Clinical Practice
Guidelines for Bone Metabolism and Disease target, high pill burden, and poor
patient compliance remain significant problems with currently available
therapies.
The newly discovered genes were identified as a result of being directly
regulated by a coactivator shown previously to be a critical regulator in
breast cancer. Graduates will
enjoy having the latest tools to enable them to capture their own memories
going forward with one of the many digital cameras available today that
resemble the traditional point-and-shoot camera.

Personalized Memory Library
Collect all of your graduate's home movies and photographs taken
throughout his formative years, and organize them on a recordable CD or DVD.

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The clinical relevance of the effect of pH on in
vitro binding of FOSRENOL(R) has not been established . Such forward-looking statements involve a number of risks
and uncertainties and are subject to change at any time.
The study, reported in Proceedings of the National Academy of Sciences,
describes a collaborative effort by Genpathway and Baylor scientists to
discover genes regulated by breast cancer-associated factors using
Genpathway's FactorPath(TM) assay. Furthermore,
QueryMode(TM) demonstrated that both SRC-3 and the transcription factor it
works through, ER, exhibited increased levels of binding to many of these
sites after stimulation of the cells with the hormone, estrogen . In contrast to an RNA microarray approach that requires
altered SRC-3 expression, these new methods allowed the identification of SRC-
3 target genes in cells without changing endogenous SRC-3 expression , reducing
the likelihood of false positives. The results reported
underscore the utility of our new methods in generating information about gene
regulation to advance understanding of disease mechanisms , and in identifying
new and better therapeutic and diagnostic targets and biomarkers for drug
discovery .

Celebrate Graduation Day with Your Most Cherished Memories

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New In Vitro Data Show That FOSRENOL(R ) May Have Greater Phosphate Binding Affinity Than Sevelamer Hydrochloride

Once bound, the FOSRENOL (R)/phosphate complex cannot pass
through the intestinal lining into the blood and is eliminated from the body,
which decreases the overall phosphate absorption from food," said Dr.D.
Diet restrictions alone generally cannot control phosphorus levels and
patients traditionally manage hyperphosphatemia by taking phosphorus-binding
agents at every meal.
The work involved identifying genes regulated by steroid receptor
coactivator-3 (SRC-3/AIB1), a protein that is overexpressed in a variety of
human cancers, including breast cancer.

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