skyscapeonhand. A phase II study is evaluating
Targretin in combination with taxotere given every three weeks.

About Targretin

Targretin is a selective retinoid X receptor (RXR) modulator with
proven efficacy as monotherapy in the treatment of cutaneous T-cell
lymphoma (CTCL). These include statements
regarding data analysis and continuing evaluation of Targretin,
potential survival benefit, potential benefits for certain patients in
lung cancer and continued development and other studies of Targretin. Additional information concerning these and
other risk factors affecting Ligand can be found in prior press
releases as well as in public periodic filings with the Securities and
Exchange Commission, available via www.
($14.

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The paperback will be in stores starting April 19th along with the
revised South Beach Diet(TM) Good Fats/Good Carbs Guide.
"My goal is to help change the way America eats, and the
availability of information on handheld devices and smart phones will
make it even more convenient for people to follow The South Beach
Diet(TM) - whether for a healthy lifestyle or weight loss," Dr. South Beach Diet(TM) OnHand provides hundreds of
suggested items and information for the most popular cuisine,
including Italian, Chinese, Greek and Mexican, all available
at their fingertips. His
goal was to help his chronically overweight heart patients get their
diets under control, thereby preventing or reversing the myriad of
heart and vascular problems associated with obesity.
Templeton Audio, an audio imprint of
Templeton Foundation Press, will be launched February 14, 2005 with ten
titles in the categories of inspiration, spirituality and health, and works
by Sir John Templeton. Templeton,
Jr.D.

The inspirational titles available in February 2005 as Templeton Audios
are:

Golden Nuggets by Sir John Templeton ($12.

Spirituality and Health audios available in March 2005 include:

The Healing Connection: The Story of a Physician 's Search for the Link
between Faith and Health by Harold G.

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com), a trusted leader in mobile
health and medical information solutions, today announced a strategic
partnership with Waterfront Media , publishers of The South Beach
Diet(TM) Online (www.
We live in a mobile society and The South Beach Diet(TM) OnHand
solution allows consumers to access the diet information whenever and
wherever they need it./April 2003) has remained on the New York Times bestseller list
for 24 months running - since it was first published in April 2003."
Filled with easy-to-prepare recipes that focus on the right carbs
and the right fats -- the secret to South Beach Diet(TM) weight-loss
-- this mobile application makes it a snap to follow the South Beach
Diet(TM)., who serves as president of Templeton Foundation Press and the
John Templeton Foundation.
Please see contact information at end of release.

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The South Beach Diet(TM) was written by Dr."
"The South Beach Diet(TM), is a great way to eat for life, that
makes you look healthy and feel healthy," said Sandeep Shah, president
and CEO of Skyscape. With Skyscape's South Beach
Diet(TM) OnHand for the PDA and Smart Phone they have a new resource
to trim their worries away. In addition to the diet basics and information dieters need,
the application contains a number of additional resources that are
regularly updated to provide fresh information:

The Daily Dish-- This daily e-mail newsletter regularly offers
new South Beach Diet(TM) recipes, the latest research, success
stories and diet news to provide consumers more variety in
their meal selection. For more
information about Skyscape, visit www. Waterfront Media opened its doors in January
2002 and currently serves over 500,000 paid subscribers.

Investigators Present Detailed Targretin Lung Cancer Data from SPIRIT I + II Trials at ASCO

ligand. 773-702-7000 and fax 773-702-7212 (outside U. Included
are Koenig's findings on the impact of faith on mental and physical health
and the realization that religious faith and practice are connected to
mental and physical health.

arts i

com), to bring one of the most
popular diets to health-conscious consumers via their mobile devices.95. To download the
software, consumers can visit www. South Beach
Diet(TM) OnHand will distributed to healthcare professionals via
www. Waterfront 's
leading authorities encompass diet, health, finance, exercise,
spirituality and religion, and relationships. and Canada); tel.S. Koenig,
M.95)

Running time: TBD
ISBN: 1-932031-82-0
Read by: Bea Brannon
Category: Personal growth

Thought-provocative questions designed to help people live happier and more
useful lives by becoming more aware of the spiritual principles that
operate in the universe and putting them into daily practice.

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(www.
With 9 million books in print, The South Beach Diet(TM) (Rodale
Inc. His
pioneering work in noninvasive cardiac imaging has resulted in
computerized tomography scanning methods and measures that bear his
name: the Agatston Score and the Agatston Method, which are used for
screening coronary calcium, are recognized worldwide. Skyscape's solutions are available on multiple platforms,
including Palm OS(R), Windows (R) CE and Pocket PC.skyscape. Additional information
about Waterfront Media's partners, products and online tools can be
found at www.
In December 1999, the FDA approved Targretin capsules for the
treatment of cutaneous manifestations of cutaneous t-cell lymphoma in
patients who are refractory to at least one prior systemic therapy.
The European Commission granted marketing authorization for Targretin
capsules in March 2001, and the product is currently marketed in many
major European countries, including Germany, the United Kingdom,
France, and Italy.com

Caution Regarding Forward-Looking Statements

This news release contains forward-looking statements within the
meaning of section 21E of the Securities Exchange Act of 1934, as
amended, that involve risks and uncertainties and reflect Ligand's
judgment as of the date of this release. Now, wherever and whenever people
listen to audio books, they'll have the option of listening to, as well as
reading, our books that extend the dialogue between science and religion,
promote ethical values and the development of character, and encourage a
humble approach in all of life's endeavors. Myers ($12. ($14.

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The South Beach Diet Just Got Handier - Skyscape Brings The South Beach Diet to Mobile Devices With South Beach Diet OnHand

They will also receive sample meal plans
for all three phases of the diet .com. Today over 400,000 medical
professionals trust Skyscape to help them make the most informed
decisions at the point-of-care.com.

irenaeus i

Arthur Agatston, M. The South
Beach Diet(TM) Online has over 4 million subscribers to its daily
e-mail newsletter, The Daily Dish.

Motivational Tips and Q+As-- South Beach Diet(TM) OnHand
provides consumers with daily motivation tips and Q+As
downloadable to you handheld three times a week, to answer the
most common questions and dispel misperceptions. Agatston's goal of helping to change the way America
eats.

About Dr.D. The oral presentations were
given at a lung cancer session at the annual meeting of the American
Society of Clinical Oncology in Orlando on Saturday, that occurred more frequently with Targretin included
hypertriglyceridemia in both trials, neutropenia, asthenia and
dehydration in SPIRIT II and dyspnea in SPIRIT I.

Spiritual Investments: Wall Street Wisdom from the Career of Sir John
Templeton by Gary Moore; read by Gary Moore ($12.95, 2 CDs)

Running time: approximately 1 hour, 16 minutes
ISBN: 1-932031-80-4
Read by: Frank Jacoby
Category: Inspirational

Seventeen investment principles that guided Sir John Templeton's legendary
business career, each coupled with a related spiritual principle that
reflects the interplay between the two. Koenig with Gregg Lewis ($14.

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com and through partnerships with leading providers of
mobile application downloads such as palmOne and Handango. Agatston began to investigate diets and the
origins of insulin resistance on his own.Waterfrontmedia.

The audio books are read by a variety of professionals.D.

The Sir John Templeton audio books available in April 2005 are:

Possibilities for Over One Hundredfold More Spiritual Information: The
Humble Approach in Theology and Science by Sir John Templeton ($14 .

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This application is
available for immediate download from www.
Agatston said. "Consumers need an easy way to track their
progress and stick to their diet when they are traveling, shopping for
groceries or eating in restaurants.com

About Waterfront Media

Waterfront Media is headquartered on the Waterfront of Brooklyn,
NY with customer service operations in North Adams , MA.com

Skyscape and smARTlink are registered trademarks.

Templeton Audios are available to the media for review upon request.95, 1 CD)

Running time: approximately 45 minutes
ISBN: 1-932031-81-2
Read by: Len Stea
Category: Inspirational

A collection of sayings and practical , uplifting advice based on a lifetime
of experience, designed to inspire and motivate those seeking deeper
meaning in life.95, 1 CD)

Running time: approximately 1 hour, 7 minutes
ISBN: 1 -932031-79-0
Read by: John Matthew and Lisa Friedman
Category: Inspirational

Time-tested words of wisdom about gratitude from various religious
traditions and authors, combined with narrative off the authors'
observations, including Dr.95, 6
CDs)

Running time: approximately 6 hours , 13 minutes
ISBN: 1-932031-85-5
Read by: John Matthew and Lisa Friedman
Category: Spirituality and Health

This is a remarkable personal story of Dr.

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Food/Beverage Editors/High-Tech Editors

HUDSON, Mass. The South Beach Diet(TM) OnHand is now available for
the full range of mobile devices including handhelds and Smart Phones
for just $19.skyscape., is a cardiologist and an associate
professor of medicine at the University of Miami Medical School.

About Skyscape

Skyscape, Inc. A recently-completed phase II trial evaluated
Targretin in combination with gemcitabine plus carboplatin. Two
multicenter trials are evaluating the combination of Targretin plus
taxotere as second-line treatment for relapsed NSCLC.ligand.

Purpose and Power in Retirement: New Opportunities for Meaning and
Significance by
Harold G.

i society

skyscape.
Dr . These differences
were recorded for all AEs that reached a level of 5% frequency in any
arm.

Several of the above studies are scheduled for presentation at
ASCO on Tuesday, May 17. Our stock price may suffer if any actual events differ
from our expectations.

PRESS RELEASE Templeton Foundation Press Announces Audio Versions of Its Books

"Our mission at Templeton Foundation Press is to publish and promote books
that increase the awareness of the role of spirituality in our daily
lives," explains Joanna Hill, director of Templeton Foundation Press and
manager of Templeton Audio."





Templeton Foundation Press


Each Templeton Audio book has a special introduction by John M., M.org; and by calling 800 -621-2736 or faxing 800-621-8476
(U.S.

Noble Purpose: The Joy of Living a Meaningful Life by William Damon,
Introduction by David G.95, 2 CDs)

Running time: approximately 1 hour, 20 minutes
ISBN: 1-932031-78-2
Read by: George Saris and Bea Brannon
Category: Inspirational

A guide on how to discover your calling, finding fulfillment that comes
from dedicating your life to something beyond the narrow interests of self,
and why it is so important to do so.

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95, for a full year subscription.

"The combination of South Beach Diet(TM) Online, South Beach
Diet(TM) books , The South Beach Diet(TM) foods from Kraft, and now
South Beach Diet(TM) OnHand provides an incredibly powerful set of
tools in a dieter's arsenal and can better prepare dieters to
succeed," said Ben Wollin, CEO of Waterfront Media."

Pricing and Availability

Beginning on April 27, 2005 , a one-year subscription to South
Beach Diet(TM) OnHand for the PDA can be purchased for $19.

Words of Gratitude for Mind, Body, and Soul by Robert A. Emmons' clinical research on the subject . It includes an overview of current social trends, debunks retirement
myths, and contents that successful retirement results from identifying a
higher purpose in life that leads to emotional fulfillment .

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----Today, The South
Beach Diet(TM) just got more powerful with an ideal solution for
people on the go.,
preventive cardiologist and inventor of the renowned Agatston Score. Agatston and The South Beach Diet(TM)

Arthur Agatston, M.
In April 2005, Skyscape extended its focus to provide
health -conscious consumers with mobile solutions to help improve their
health and wellness, with solutions such as The South Beach Diet(TM)
OnHand, the only mobile version of the highly successful South Beach
Diet(TM). RXR levels in the tumor have been shown to be an
independent predictor of survival in NSCLC and in other solid tumors. His commentary includes a brief description of
the content of the particular book, along with pertinent anecdotes about
his father, Sir John Templeton, now in his 90s and still deeply interested
in and involved with these books. They will be on
sale in bookstores; through the Templeton Foundation Press website,
www.D.

Why Are We Created? Increasing Our Understanding of Humanity's Purpose on
Earth by Sir John Templeton and Rebekah Alezander Dunlap ($14.

Wisdom from World Religions: Pathways toward Heaven on Earth by Sir John
Templeton ( $29.

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Fast Food Guide-- South Beach Diet(TM) OnHand gives you
variety, providing you with guidance on the best food choices
at the most popular fast food chains. Knowing that his
patients weren't faring well on the standard, low-fat American Heart
Association diet, Dr . Ligand's proprietary drug discovery and development programs
are based on its leadership position in gene transcription technology,
primarily related to Intracellular Receptors. and
Canada). Emmons and Joanna
Hill, Introduction by Brother David Steindl-Rast ($12.95)

Running time: TBD
ISBN: 1-932031-83-9
Read by: TBD
Category: Religion

Two hundred weekly sessions of study that include teachings from Judaism,
Christianity, Buddhism, Hinduism, Islam, Jainism, Confucianism, Taoism ,
Sikhism, Zen, and Zoroastrianism, selected for their ability to uplift the
mind and contribute to the growth of wisdom and a peaceful heart.

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com
Skyscape(R), Inc.
Additional information and the full data set presented at ASCO are
available on the Ligand web site at www.com

Comprehensive Clinical Trial Program

Further assessment of the role of Targretin in combination with
different chemotherapy regimens in the first-line setting continues
with several additional trials being conducted or recently completed
pending analysis.
Actual events or results may differ from our expectations . Ligand disclaims
any intent or obligation to update these forward-looking statements
beyond the date of this release.
List of Templeton Audios follows.95, 4 CDs)

Running time: approximately 3 hours, 30 minutes
ISBN: 1-932031-86-3
Read by: George Saris
Category: Spirituality and Health

A guide for healthcare professionals, helping them identify and address the
spiritual needs of their patients so they can treat the whole person; it
includes clear definitions of religious coping, spiritual assessments,
transference and counter-transference, and boundaries to care.

religion people

southbeachdiet. "The real secret to The South Beach Diet(TM) is that
it's not just a diet , it's a way to eat for life, focusing on the
right carbs and the right fats, along with lean sources of protein. Skyscape provides the most extensive portfolio of
trusted medical references - with over 270 of medicine's most trusted
and reputable references in over 35 medical specialties from the
world 's finest medical publishers. One multicenter trial is
evaluating Targretin monotherapy in 150 patients with relapsed disease
and a second trial is evaluating the combination of Targretin plus
erlonitib (Tarceva(R)).95, 6 CDs)

Running time: approximately 6 hours, 59 minutes
ISBN: 1-932031-87 -1
Read by: John Mucci and Len Stea
Category: Spirituality and Health

A practical and inspiring self-help manual that creates a purpose-filled
life.

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D. "Additionally, it
helps further Dr., is the leading provider of interactive mobile
solutions for both the health conscious consumer and the medical
practitioner. A phase
I/II trial is evaluating a dose-escalation schedule of Targretin in
combination with weekly carboplatin plus paclitaxel.
Three additional trials are being conducted or are recently
completed pending analysis in patients with NSCLC who have failed at
least two prior treatments for their cancer.

About Ligand

Ligand discovers, develops and markets new drugs that address
critical unmet medical needs of patients in the areas of cancer, pain,
skin diseases, men's and women's hormone-related diseases,
osteoporosis, metabolic disorders, and cardiovascular and inflammatory
diseases. For more information, go
to www. "Formatting our books as CDs brings their
messages to an even wider audience.

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With
this purchase, consumers will also receive a free , one week
subscription for the South Beach Diet(TM) Online. Agatston did not set out to develop a weight-loss plan. All trademarks
are the property of their respective owners.

Business Editors /Health/Medical Writers
BIOWIRE2K

SAN DIEGO----

Subgroup Analysis Reveals Significant Survival
Correlation with Triglyceride Biomarker

Detailed reports of the results of Ligand Pharmaceuticals
Incorporated (Nasdaq:LGND) two pivotal Phase III studies of
Targretin(R) (bexarotene) capsules in front-line combination therapy
with standard chemotherapy to treat advanced non-small cell lung
cancer (NSCLC) were presented Saturday. A multicenter
randomized phase II trial is evaluating Targretin capsules given
either concomitantly to or sequentially after the administration of
weekly carboplatin plus paclitaxel. For
example, there can be no assurance that other studies or evaluations
of Targretin will be favorable or that they will confirm results of
previous trials, that data evaluation will be completed or demonstrate
any hypothesis or endpoint , that Targretin will provide any benefits
or be useful in new indications alone or in combination with other
drugs, that marketing applications will be filed or, if filed,
approved, either by Ligand or its corporate partners, nor that further
clinical or commercial development of Targretin will be completed or
successful. Harold Koenig, showing how his
personal trials became the catalyst for his pioneering research.

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Restaurant Guides--With just the tap of a stylus, South Beach
dieters can find the best foods to eat in various types of
restaurants.skyscapeonhand .ligand.templetonpress.

Spirituality in Patient Care: Why, How, When, and What by Harold G.95 )

Running time: TBD
ISBN: 1-932031-84-7
Read by: TBD
Category: Spirituality and Philosophy

Sir John issues a challenge to apply the same energy that has been devoted
to scientific inquiry to the pursuit of spiritual information, noting that
the benefits of extending spiritual knowledge might exceed the benefits we
have realized thus far from scientific and medical advances.

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Strategically , partnering with Skyscape, a company trusted by
more than 400,000 professionals for mobile health and medical
information solutions, was the best way to add this functionality for
the convenience of dieters. The result was The South
Beach Diet(TM), The South Beach Diet(TM) Cookbook, and The South Beach
Diet(TM) Good Fats/Good Carbs Guide published by Rodale Inc. This
subscription-based online publishing company featuring self-help
products connects subscribers with trusted experts to assist them in
improving their lives.

Koenig, M.

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